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Sci. Signal., 12 March 2013
Vol. 6, Issue 266, p. mr1
[DOI: 10.1126/scisignal.2003906]


The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape

Jean Rosenbaum1,2*, Sung Hee Baek3{dagger}, Anindya Dutta4{dagger}, Walid A. Houry5{dagger}, Otmar Huber6{dagger}, Ted R. Hupp7{dagger}, and Pedro M. Matias8{dagger}

1 Université Bordeaux, Physiopathologie du Cancer du Foie, U1053, F-33000 Bordeaux, France.
2 INSERM, Physiopathologie du Cancer du Foie, U1053, F-33000 Bordeaux, France.
3 Department of Biological Sciences, Creative Research Initiatives Center for Chromatin Dynamics, Seoul National University, Seoul 151-742, South Korea.
4 Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
5 Department of Biochemistry, University of Toronto, 1 King’s College Circle, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada.
6 Department of Biochemistry II, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
7 Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
8 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apartado 127, 2780 Oeiras, Portugal.

{dagger} These authors contributed equally to this work.

Meeting Information:The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2) took place at the European Institute for Chemistry and Biology in Pessac, France, 16 to 19 October 2012.

Abstract: Pontin (also known as RUVBL1 and RVB1) and Reptin (also called RUVBL2 and RVB2) are related members of the large AAA+ (adenosine triphosphatase associated with diverse cellular activities) superfamily of conserved proteins. Various cellular functions depend on Pontin and Reptin, mostly because of their functions in the assembly of protein complexes that play a role in the regulation of cellular energetic metabolism, transcription, chromatin remodeling, and the DNA damage response. Little is known, though, about the interconnections between these multiple functions, how the relevant signaling pathways are regulated, whether the interconnections are affected in human disease, and whether components of these pathways are suitable targets for therapeutic intervention. The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2), held between 16 and 19 October 2012, discussed the nature of the oligomeric organization of these proteins, their structures, their roles as partners in various protein complexes, and their involvement in cellular regulation, signaling, and pathophysiology, as well as their potential for therapeutic targeting. A major outcome of the meeting was a general consensus that most functions of Pontin and Reptin are related to their roles as chaperones or adaptor proteins that are important for the assembly and function of large signaling protein complexes.

* Corresponding author. E-mail: jean.rosenbaum{at}

Citation: J. Rosenbaum, S. H. Baek, A. Dutta, W. A. Houry, O. Huber, T. R. Hupp, P. M. Matias, The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape. Sci. Signal. 6, mr1 (2013).

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