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Sci. Signal., 26 March 2013
Vol. 6, Issue 268, p. eg3
Focus Issue: From Genomic Mutations to Oncogenic Pathways
Nancy R. Gough1*
1 Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.
This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.
Jianjiong Gao, Bülent Arman Aksoy, Ugur Dogrusoz, Gideon Dresdner, Benjamin Gross, S. Onur Sumer, Yichao Sun, Anders Jacobsen, Rileen Sinha, Erik Larsson, Ethan Cerami, Chris Sander, and Nikolaus Schultz (2 April 2013) Sci. Signal.6 (269), pl1.
[DOI: 10.1126/scisignal.2004088] |Abstract »|Full Text »|PDF »|Supplementary Materials »
Anne Roulston, William J. Muller, and Gordon C. Shore (26 March 2013) Sci. Signal.6 (268), pe12.
[DOI: 10.1126/scisignal.2004113] |Abstract »|Full Text »|PDF »
Catherine Hartzell, Olga Ksionda, Ed Lemmens, Kristen Coakley, Ming Yang, Monique Dail, Richard C. Harvey, Christopher Govern, Jeroen Bakker, Tineke L. Lenstra, Kristin Ammon, Anne Boeter, Stuart S. Winter, Mignon Loh, Kevin Shannon, Arup K. Chakraborty, Matthias Wabl, and Jeroen P. Roose (26 March 2013) Sci. Signal.6 (268), ra21.
[DOI: 10.1126/scisignal.2003848] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »