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Sci. Signal., 9 April 2013
Vol. 6, Issue 270, p. jc1
[DOI: 10.1126/scisignal.2003945]

JOURNAL CLUB

Neuregulin-1 Type I: A Hidden Power Within Schwann Cells for Triggering Peripheral Nerve Remyelination

Anand Krishnan*

The author is a postdoctoral fellow in the Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.

Abstract: Physiological interactions and reciprocal signaling between axons and Schwann cells play critical roles in nerve development and survival. Axonally derived neuregulin-1 (NRG-1) type III is an essential modulator of Schwann cells during development, nerve repair, and remyelination. A recent report demonstrates an unexpected regulatory role for Schwann cell–derived NRG-1 type I in Schwann cell plasticity and remyelination after peripheral nerve injury. Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs.

* Corresponding author. E-mail: akrishna{at}ucalgary.ca

Citation: A. Krishnan, Neuregulin-1 Type I: A Hidden Power Within Schwann Cells for Triggering Peripheral Nerve Remyelination. Sci. Signal. 6, jc1 (2013).

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