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Sci. Signal., 16 April 2013
Vol. 6, Issue 271, p. pc10
[DOI: 10.1126/scisignal.2004186]


Science Signaling Podcast: 16 April 2013

Guanglei Zhuang1, Napoleone Ferrara1*, and Annalisa M. VanHook2

1 Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005, USA.

* Present address: Department of Pathology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract: This Podcast features an interview with Guanglei Zhuang and Napoleone Ferrara, authors of a Research Article that appears in the 16 April 2013 issue of Science Signaling. Zhuang and Ferrara discuss results from their analysis of the temporal dynamics of protein phosphorylation events downstream of vascular endothelial growth factor (VEGF) receptor activation. VEGFs are secreted growth factors that promote angiogenesis, and they promote growth of blood vessels during normal development, in wound healing, and into tissues that are deprived of oxygen. VEGF-mediated vascularization of tumors is implicated in cancer growth and progression, and VEGFs play a role in pathologies that are characterized by the abnormal growth of blood vessels, such as diabetic retinopathy and age-related macular degeneration. Drugs that inhibit VEGF or block the activity of signaling proteins downstream of VEGF receptors are used clinically to block VEGF activity in the context of pathologic vascularization. Thus, understanding the intricacies of VEGF signaling is important for devising new ways to treat VEGF-dependent vascular pathologies.

Citation: G. Zhuang, N. Ferrara, A. M. VanHook, Science Signaling Podcast: 16 April 2013. Sci. Signal. 6, pc10 (2013).

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