Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 30 April 2013
Vol. 6, Issue 273, p. pe15
[DOI: 10.1126/scisignal.2004188]

PERSPECTIVES

Histone Demethylases Set the Stage for Cancer Metastasis

Jian Cao and Qin Yan*

Department of Pathology, Yale School of Medicine, New Haven, CT 06520–8023, USA.

Abstract: Metastasis is the major cause of cancer-related mortality. It is increasingly evident that epigenetic alterations in tumor cells enable them to overcome various barriers in this multistage process of cell spreading, and insight into the molecular roles of epigenetic regulators in tumor metastasis are just beginning to emerge. Histone demethylases appear to have critical roles in creating suitable epigenetic states for tumor cells to gain metastatic potential. These studies shed light on the roles of histone demethylases in tumor metastasis and highlight the importance of targeting these enzymes to suppress metastatic disease.

* Corresponding author. E-mail: qin.yan{at}yale.edu

Citation: J. Cao, Q. Yan, Histone Demethylases Set the Stage for Cancer Metastasis. Sci. Signal. 6, pe15 (2013).

Read the Full Text



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882