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Sci. Signal., 3 September 2013
Vol. 6, Issue 291, p. pe27
Angiomoting YAP into the Nucleus for Cell Proliferation and Cancer Development
Institute of Molecular and Cell Biology, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Pharmaceutical Sciences, Xiamen University, Fujian, China.
The Hippo pathway regulates cell proliferation and apoptosis during development, tissue regeneration, and carcinogenesis. Nuclear translocation of the transcription factors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) and their subsequent interaction with TEA domain (TEAD) transcriptional factors program pro-proliferative and antiapoptotic transcription. Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation. In this issue of Science Signaling, Yi et al. show that Amot may also promote nuclear translocation of YAP and act as a transcriptional cofactor of the YAP-TEAD complex to facilitate proliferation of biliary epithelial cells and cancer development of the liver either in response to tissue injury or in the absence of the tumor suppressor Merlin. These seemingly controversial results highlight that our understanding of Amot proteins in the Hippo pathway is so far limited.
Annalisa M. VanHook (16 July 2013) Sci. Signal.6 (284), ec163.
[DOI: 10.1126/scisignal.2004511] |Abstract »
Annalisa M. VanHook (12 February 2013) Sci. Signal.6 (262), ec38.
[DOI: 10.1126/scisignal.2004053] |Abstract »
Annalisa M. VanHook (18 September 2012) Sci. Signal.5 (242), ec245.
[DOI: 10.1126/scisignal.2003613] |Abstract »
Jonathan Cooper, Wei Li, Liru You, Gaia Schiavon, Angela Pepe-Caprio, Lu Zhou, Ryohei Ishii, Marco Giovannini, C. Oliver Hanemann, Stephen B. Long, Hediye Erdjument-Bromage, Pengbo Zhou, Paul Tempst, and Filippo G. Giancotti (30 August 2011) Sci. Signal.4 (188), pt6.
[DOI: 10.1126/scisignal.2002314] |Abstract »|Full Text »|PDF »|Slideshow »
Giovanni Blandino, Yosef Shaul, Sabrina Strano, Marius Sudol, and Michael Yaffe (3 November 2009) Sci. Signal.2 (95), mr6.
[DOI: 10.1126/scisignal.295mr6] |Abstract »|Full Text »|PDF »