Sci. Signal., 17 September 2013
Science Signaling Podcast: 17 September 2013
Peter J. Parker1,2, Mark Linch1, Neil Q. McDonald3,4, and Annalisa M. VanHook5
1 Protein Phosphorylation Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Abstract: This Podcast features an interview with Peter Parker, Mark Linch, and Neil McDonald, authors of a Research Article that appears in the 17 September 2013 issue of Science Signaling. Atypical protein kinase C (PKC) is a serine-threonine kinase that affects many cellular processes, including apical-basal polarity in epithelial cells. Loss of cell polarity is associated with aggressive epithelial cell cancers, and PKC is frequently found in abnormally high abundance in epithelial cancers. Linch et al. identified a motif within PKC that mediates interactions between PKC and some of its substrates that control cell polarity. They also found that an amino acid within this motif is commonly affected in PKC mutants associated with human cancer.
Citation: P. J. Parker, M. Linch, N. Q. McDonald, A. M. VanHook, Science Signaling Podcast: 17 September 2013. Sci. Signal. 6, pc24 (2013).
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