Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Sci. Signal., 8 October 2013
Vol. 6, Issue 296, p. re7
Hippo Gains Weight: Added Insights and Complexity to Pathway Control
Leonie Enderle1,2 and
1 Biozentrum, University of Basel, 4056 Basel, Switzerland. 2 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
The Hippo pathway is a kinase cascade, formed by Hippo, Salvador, Warts, and Mats, that regulates the subcellular distribution and transcriptional activity of Yorkie. Yorkie is a transcriptional coactivator that promotes the expression of genes that inhibit apoptosis and drive cell proliferation. We review recent studies indicating that activity of the Hippo pathway is controlled by cell-cell junctions, cell adhesion molecules, scaffolding proteins, and cytoskeletal proteins, as well as by regulators of apical-basal polarity and extracellular tension.
Amber L. Couzens, James D. R. Knight, Michelle J. Kean, Guoci Teo, Alexander Weiss, Wade H. Dunham, Zhen-Yuan Lin, Richard D. Bagshaw, Frank Sicheri, Tony Pawson, Jeffrey L. Wrana, Hyungwon Choi, and Anne-Claude Gingras (19 November 2013) Sci. Signal.6 (302), rs15.
[DOI: 10.1126/scisignal.2004712] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »
L. Bryan Ray (12 November 2013) Sci. Signal.6 (301), ec274.
[DOI: 10.1126/scisignal.2004893] |Abstract »
Annalisa M. VanHook (15 October 2013) Sci. Signal.6 (297), ec249.
[DOI: 10.1126/scisignal.2004811] |Abstract »
Emad Heidary Arash and Liliana Attisano (14 May 2013) Sci. Signal.6 (275), pe18.
[DOI: 10.1126/scisignal.2004259] |Abstract »|Full Text »|PDF »
Jane I. Lin, Carole L. C. Poon, and Kieran F. Harvey (22 January 2013) Sci. Signal.6 (259), pe4.
[DOI: 10.1126/scisignal.2003813] |Abstract »|Full Text »|PDF »