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Sci. Signal., 10 December 2013
Vol. 6, Issue 305, p. pc33
[DOI: 10.1126/scisignal.2004950]

PODCASTS

Science Signaling Podcast: 10 December 2013

Judith K. Davie1 and Annalisa M. VanHook2

1 Department of Biochemistry and Molecular Biology and Simmons Cancer Institute, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
2 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This is an interview with Judith Davie, senior author of a Research Article published in the 10 December 2013 issue of Science Signaling, about how an inflammatory cytokine interferes with muscle repair. Inflammatory cytokines are produced at sites of infection and tissue damage, and they promote the inflammatory processes that fight pathogens and initiate tissue repair. When skeletal muscles are damaged, they secrete the inflammatory cytokine interferon-{gamma} (IFN-{gamma}), which helps muscles heal. Although transient production of IFN-{gamma} is required for repairing damaged muscle, too much of it hinders repair. Priya Londhe and Judith Davie report that excess IFN-{gamma} represses the expression of muscle-specific genes that are required for the differentation of new muscle cells.

Citation: J. K. Davie, A. M. VanHook, Science Signaling Podcast: 10 December 2013. Sci. Signal. 6, pc33 (2013).

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