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Sci. Signal., 14 January 2014
Vol. 7, Issue 308, p. pc2
[DOI: 10.1126/scisignal.2004995]


Science Signaling Podcast: 14 January 2014

Moses V. Chao1, Eric Klann2, and Annalisa M. VanHook3

1 Departments of Cell Biology, Physiology and Neuroscience, and Psychiatry; Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Langone School of Medicine, New York, NY 10016, USA.
2 Center for Neural Science, New York University, New York, NY 10003, USA.
3 Web Editor, Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005, USA.

Abstract: This Podcast features an interview with Eric Klann and Moses Chao, authors of a Research Article that appears in the 14 January 2014 issue of Science Signaling, about a signaling pathway that plays a role in mediating some of the effects of the antipsychotic drug haloperidol. First-generation antipsychotic drugs such as haloperidol block dopamine signaling and have been used to treat acute psychosis and long-term conditions like schizophrenia since the 1950s. Whereas haloperidol can reduce psychotic behavior in a few hours, it takes weeks of treatment for patients to see the full effects of the drug. Bowling et al. report that haloperidol induces both short-term and long-term effects on cultured neurons through the Akt-mTOR pathway.

Citation: M. V. Chao, E. Klann, A. M. VanHook, Science Signaling Podcast: 14 January 2014. Sci. Signal. 7, pc2 (2014).

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