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Sci. Signal., 28 January 2014
Vol. 7, Issue 310, p. pe2
[DOI: 10.1126/scisignal.2005024]

PERSPECTIVES

O ROM(e)O1, ROM(e)O1, Wherefore Art Thou ROM(e)O1?

Martina Semenzato and Luca Scorrano*

Department of Biology and Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, University of Padova, Padova 35121, Italy.

Abstract: Mitochondria are not only a source but also a target of reactive oxygen species (ROS). However, the molecular mechanisms by which ROS affect mitochondrial function are poorly defined. In this issue, Screaton and colleagues report that ROS modulator protein 1 (ROMO1) links ROS and mitochondrial morphology and ultrastructure by modulating cristae remodeling and mitochondrial fusion that depends on the guanosine triphosphatase Opa1. Their work indicates how the oxidative milieu triggers mitochondrial shape changes.

* Corresponding author. E-mail: luca.scorrano{at}unipd.it

Citation: M. Semenzato, L. Scorrano, O ROM(e)O1, ROM(e)O1, Wherefore Art Thou ROM(e)O1? Sci. Signal. 7, pe2 (2014).

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