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Sci. Signal., 18 February 2014
Vol. 7, Issue 313, p. pe5
[DOI: 10.1126/scisignal.2005108]

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Cracking the NF-{kappa}B Code

Karen E. Tkach, Jennifer E. Oyler, and Grégoire Altan-Bonnet*

ImmunoDynamics Group, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract: The discovery of feedback loops between signaling and gene expression is ushering in new quantitative models of cellular regulation. In a recent issue of Science Signaling, Sung et al. showed how positive feedback downstream of nuclear factor {kappa}B (NF-{kappa}B) signaling enhances the capacity of macrophages to scale their antimicrobial responses to the dose of pathogen-associated molecular cues. This finding stemmed from analysis of cell-to-cell variability and computational modeling of time integration between signaling and transcriptional responses. Ultimately, such quantitative approaches challenge the oft-assumed time separation of "fast" signal transduction followed by "slow" gene expression, and they provide a better understanding of complex biological regulation over long time scales.

* Corresponding author. E-mail: altanbog{at}mskcc.org

Citation: K. E. Tkach, J. E. Oyler, G. Altan-Bonnet, Cracking the NF-{kappa}B Code. Sci. Signal. 7, pe5 (2014).

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