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Sci. STKE, 16 January 2001
Vol. 2001, Issue 65, p. pe1
[DOI: 10.1126/stke.2001.65.pe1]

PERSPECTIVES

New Responsibilities for the PI3K Regulatory Subunit p85α

Klaus Okkenhaug and Bart Vanhaesebroeck

The authors are at the Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 8BT, UK. E-mail: klaus{at}ludwig.ucl.ac.uk, bartvanh{at}ludwig.ucl.ac.uk

Abstract: Class IA phosphoinositide-3 kinases (PI3Ks) are heterodimeric enzymes that regulate many signal transduction pathways. The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids. Recent studies present evidence for an additional role for p85α in the regulation of actin cytoskeleton. Okkenhaug and Vanhaesebroeck discuss these results and ask whether experiments describing p85α knockout mice need to be reinterpreted.

Citation: K. Okkenhaug, B. Vanhaesebroeck, New Responsibilities for the PI3K Regulatory Subunit p85α. Sci. STKE 2001, pe1 (2001).

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