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Sci. STKE, 17 July 2001
Vol. 2001, Issue 91, p. pe1
[DOI: 10.1126/stke.2001.91.pe1]


Slit: A Roadblock for Chemotaxis

Aaron Z. Fernandis and Ramesh K. Ganju

The authors are at the Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA. E-mail: rganju{at}

Abstract: The immune system and nervous system display striking similarities. Fernandis and Ganju discuss yet another example where a protein (Slit) originally identified for its role in modulating axon pathfinding is able to regulate immune cell migration. Slit isoforms expressed in the nervous system interact with members of the Robo receptor family to modify movement stimulated by the secreted attractants netrins and their receptors. In leukocytes, Slit 2 interacting with Robo receptors inhibits movement stimulated by the chemokine receptor (CXCR4). Fernandis and Ganju discuss the therapeutic potential of Slit as an antiviral agent and in the treatment of inflammatory diseases, autoimmune disorders, and cancer.

Citation: A. Z. Fernandis, R. K. Ganju, Slit: A Roadblock for Chemotaxis. Sci. STKE 2001, pe1 (2001).

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Slit2-Robo4 Pathway Modulates Lipopolysaccharide-Induced Endothelial Inflammation and Its Expression Is Dysregulated during Endotoxemia.
H. Zhao, A. R. Anand, and R. K. Ganju (2014)
J. Immunol. 192, 385-393
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