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Sci. STKE, 17 July 2001 PERSPECTIVESSlit: A Roadblock for ChemotaxisAaron Z. Fernandis, and Ramesh K. Ganju The authors are at the Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA. E-mail: rganju{at}caregroup.harvard.edu Abstract: The immune system and nervous system display striking similarities. Fernandis and Ganju discuss yet another example where a protein (Slit) originally identified for its role in modulating axon pathfinding is able to regulate immune cell migration. Slit isoforms expressed in the nervous system interact with members of the Robo receptor family to modify movement stimulated by the secreted attractants netrins and their receptors. In leukocytes, Slit 2 interacting with Robo receptors inhibits movement stimulated by the chemokine receptor (CXCR4). Fernandis and Ganju discuss the therapeutic potential of Slit as an antiviral agent and in the treatment of inflammatory diseases, autoimmune disorders, and cancer. Citation: © 2001 American Association for the Advancement of Science
Citation: A. Z. Fernandis, R. K. Ganju, Slit: A Roadblock for Chemotaxis. Sci. STKE 2001, pe1 (2001). The editors suggest the following Related Resources on Science sites:In Science Signaling
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)
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