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Sci. STKE, 7 August 2001
Vol. 2001, Issue 94, p. pe2
[DOI: 10.1126/stke.2001.94.pe2]


Neuronal Signaling through Alternative Splicing: Some Exons CaRRE...

Kevin J. O'Donovan and Robert B. Darnell

The authors are in the Laboratory of Molecular Neuro-Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. E-mail: darnelr{at}

Abstract: Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.

Citation: K. J. O'Donovan, R. B. Darnell, Neuronal Signaling through Alternative Splicing: Some Exons CaRRE... Sci. STKE 2001, pe2 (2001).

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