Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Development 130 (11): 2429-2441

Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling

B. V. Latinkic1, S. Mercurio1,2, B. Bennett1, E. M. A. Hirst1, Q. Xu1, L. F. Lau3, T. J. Mohun1, and J. C. Smith1,2,*

1 Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
2 Wellcome Trust/Cancer Research UK Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
3 Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607-7170, USA

* Author for correspondence (e-mail: jim{at}welc.cam.ac.uk)

Accepted for publication 20 February 2003.

Abstract: Cyr61 is a secreted, heparin-binding, extracellular matrix-associated protein whose activities include the promotion of adhesion and chemotaxis, and the stimulation of fibroblast and endothelial cell growth. Many, if not all, of these activities of Cyr61 are mediated through interactions with integrins. We explore the role of Cyr61 in the early development of Xenopus laevis. Gain- and loss-of-function experiments show that Xcyr61 is required for normal gastrulation movements. This role is mediated in part through the adhesive properties of Xcyr61 and its related ability to modulate assembly of the extracellular matrix. In addition, Xcyr61 can, in a context-dependent manner, stimulate or inhibit signalling through the Wnt pathway. These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation.

Key Words: Xenopus • Cyr61 • CCN family • Wnt signalling • Cell adhesion • Gastrulation


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Degradome Products of the Matricellular Protein CCN1 as Modulators of Pathological Angiogenesis in the Retina.
J. Choi, A. Lin, E. Shrier, L. F. Lau, M. B. Grant, and B. Chaqour (2013)
J. Biol. Chem. 288, 23075-23089
   Abstract »    Full Text »    PDF »
Evolutionary plasticity of segmentation clock networks.
A. J. Krol, D. Roellig, M.-L. Dequeant, O. Tassy, E. Glynn, G. Hattem, A. Mushegian, A. C. Oates, and O. Pourquie (2011)
Development 138, 2783-2792
   Abstract »    Full Text »    PDF »
Connective Tissue Growth Factor Enhances Osteoblastogenesis in Vitro.
A. Smerdel-Ramoya, S. Zanotti, V. Deregowski, and E. Canalis (2008)
J. Biol. Chem. 283, 22690-22699
   Abstract »    Full Text »    PDF »
Nephroblastoma Overexpressed (Nov) Inhibits Osteoblastogenesis and Causes Osteopenia.
S. Rydziel, L. Stadmeyer, S. Zanotti, D. Durant, A. Smerdel-Ramoya, and E. Canalis (2007)
J. Biol. Chem. 282, 19762-19772
   Abstract »    Full Text »    PDF »
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
A. Leask and D. J. Abraham (2006)
J. Cell Sci. 119, 4803-4810
   Abstract »    Full Text »    PDF »
The Matricellular Protein CCN1 Is Essential for Cardiac Development.
F.-E Mo and L. F. Lau (2006)
Circ. Res. 99, 961-969
   Abstract »    Full Text »    PDF »
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression.
J.-S. Nam, T. J. Turcotte, P. F. Smith, S. Choi, and J. K. Yoon (2006)
J. Biol. Chem. 281, 13247-13257
   Abstract »    Full Text »    PDF »
CCN1/Cyr61 Is Regulated by the Canonical Wnt Signal and Plays an Important Role in Wnt3A-Induced Osteoblast Differentiation of Mesenchymal Stem Cells.
W. Si, Q. Kang, H. H. Luu, J. K. Park, Q. Luo, W.-X. Song, W. Jiang, X. Luo, X. Li, H. Yin, et al. (2006)
Mol. Cell. Biol. 26, 2955-2964
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of UDP-glucose Dehydrogenase from the Amphibian Xenopus laevis and Its Involvement in Hyaluronan Synthesis.
D. Vigetti, M. Ori, M. Viola, A. Genasetti, E. Karousou, M. Rizzi, F. Pallotti, I. Nardi, V. C. Hascall, G. De Luca, et al. (2006)
J. Biol. Chem. 281, 8254-8263
   Abstract »    Full Text »    PDF »
CCN2 (Connective Tissue Growth Factor) Promotes Fibroblast Adhesion to Fibronectin.
Y. Chen, D. J. Abraham, X. Shi-wen, J. D. Pearson, C. M. Black, K. M. Lyons, and A. Leask (2004)
Mol. Biol. Cell 15, 5635-5646
   Abstract »    Full Text »    PDF »
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK.
F. Unterseher, J. A. Hefele, K. Giehl, E. M. De Robertis, D. Wedlich, and A. Schambony (2004)
EMBO J. 23, 3259-3269
   Abstract »    Full Text »    PDF »
Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex.
S. Mercurio, B. Latinkic, N. Itasaki, R. Krumlauf, and J. C. Smith (2004)
Development 131, 2137-2147
   Abstract »    Full Text »    PDF »
Wise, a context-dependent activator and inhibitor of Wnt signalling.
N. Itasaki, C. M. Jones, S. Mercurio, A. Rowe, P. M. Domingos, J. C. Smith, and R. Krumlauf (2003)
Development 130, 4295-4305
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882