Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Development 134 (21): 3795-3804

Slit and Robo control the development of dendrites in Drosophila CNS

Marie-Pierre Furrer, Irina Vasenkova, Daichi Kamiyama*, Yaira Rosado, and Akira Chiba*,{dagger}

Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA.

{dagger} Author for correspondence (e-mail: akira.chiba{at}

Accepted for publication 4 July 2007.

Abstract: The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo. However, in cultured neurons, these molecules promote dendritic development. Here we examine the aCC motoneuron, one of the first CNS neurons to generate dendrites in Drosophila. Slit displays a dynamic concentration topography that prefigures aCC dendrogenesis. Genetic deletion of Slit leads to complete loss of aCC dendrites. Robo is cell-autonomously required in aCC motoneurons to develop dendrites. Our results demonstrate that Slit and Robo control the development of dendrites in the embryonic CNS.

Key Words: Dendrite • Slit • Robo

A Sympathetic Neuron Autonomous Role for Egr3-Mediated Gene Regulation in Dendrite Morphogenesis and Target Tissue Innervation.
D. H. Quach, M. Oliveira-Fernandes, K. A. Gruner, and W. G. Tourtellotte (2013)
J. Neurosci. 33, 4570-4583
   Abstract »    Full Text »    PDF »
Methods for Exploring the Genetic Control of Sensory Neuron Dendrite Morphogenesis in Drosophila.
B. R. Shrestha and W. B. Grueber (2011)
Cold Spring Harb Protoc 2011, pdb.top123
   Abstract »    Full Text »    PDF »
Engrailed homeoprotein acts as a signaling molecule in the developing fly.
S. Layalle, M. Volovitch, B. Mugat, N. Bonneaud, M.-L. Parmentier, A. Prochiantz, A. Joliot, and F. Maschat (2011)
Development 138, 2315-2323
   Abstract »    Full Text »    PDF »
Drosophila Neurexin IV Interacts with Roundabout and Is Required for Repulsive Midline Axon Guidance.
S. Banerjee, K. Blauth, K. Peters, S. L. Rogers, A. S. Fanning, and M. A. Bhat (2010)
J. Neurosci. 30, 5653-5667
   Abstract »    Full Text »    PDF »
Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila.
H. Long, Y. Ou, Y. Rao, and D. J. van Meyel (2009)
Development 136, 3475-3484
   Abstract »    Full Text »    PDF »
Molecules and mechanisms of dendrite development in Drosophila.
M. M. Corty, B. J. Matthews, and W. B. Grueber (2009)
Development 136, 1049-1061
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882