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Department of Cell and Developmental Biology, University of Illinois,
Urbana, IL 61801, USA.
Author for correspondence (e-mail:
Accepted for publication 4 July 2007.
The molecular mechanisms that generate dendrites in the CNSare poorly
understood. The diffusible signal molecule Slit andthe neuronally expressed
receptor Robo mediate growth cone collapsein vivo. However, in cultured
neurons, these molecules promotedendritic development. Here we examine the
aCC motoneuron, oneof the first CNS neurons to generate dendrites in
Drosophila.Slit displays a dynamic concentration topography that
prefiguresaCC dendrogenesis. Genetic deletion of Slit leads to completeloss
of aCC dendrites. Robo is cell-autonomously required inaCC motoneurons to
develop dendrites. Our results demonstratethat Slit and Robo control the
development of dendrites in theembryonic CNS.
Key Words: Dendrite Slit Robo
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