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Genes & Dev. 22 (8): 955-959

Copyright © 2008 by Cold Spring Harbor Laboratory Press.

PERSPECTIVE

Semaphorin signaling in morphogenesis: found in translation

Andrew D. Chisholm1

Division of Biological Sciences, Section of Neurobiology, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093, USA

Abstract: Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025–1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.

Key Words: C. elegans • cofilin • eIF2 • epidermal morphogenesis • mRNA translation • semaphorin]

1 Correspondence.

E-MAIL chisholm{at}ucsd.edu; FAX (858) 534-7773.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1669308.

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