Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Genes & Dev. 23 (1): 12-17

Copyright © 2009 by Cold Spring Harbor Laboratory Press.


RESEARCH COMMUNICATION

Systemic regulation of starvation response in Caenorhabditis elegans

Chanhee Kang1, and Leon Avery

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA

Abstract: When the supply of environmental nutrients is limited, multicellular animals can make both physiological and behavioral changes so as to cope with nutrient starvation. Although physiological and behavioral effects of starvation are well known, the mechanisms by which animals sense starvation systemically remain elusive. Furthermore, what constituent of food is sensed and how it modulates starvation response is still poorly understood. In this study, we use a starvation-hypersensitive mutant to identify molecules and mechanisms that modulate starvation signaling. We found that specific amino acids could suppress the starvation-induced death of gpb-2 mutants, and that MGL-1 and MGL-2, Caenorhabditis elegans homologs of metabotropic glutamate receptors, were involved. MGL-1 and MGL-2 acted in AIY and AIB neurons, respectively. Treatment with leucine suppressed starvation-induced stress resistance and life span extension in wild-type worms, and mutation of mgl-1 and mgl-2 abolished these effects of leucine. Taken together, our results suggest that metabotropic glutamate receptor homologs in AIY and AIB neuron may modulate a systemic starvation response, and that C. elegans senses specific amino acids as an anti-hunger signal.

Key Words: Starvation • amino acid response • autophagy • hormesis

Received for publication July 31, 2008. Accepted for publication November 14, 2008.


1 Corresponding author.

E-MAIL Chanhee.Kang{at}UTSouthwestern.edu; FAX (214) 648-1488.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1723409.

Supplemental material is available at http://www.genesdev.org.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
To Grow or Not to Grow: Nutritional Control of Development During Caenorhabditis elegans L1 Arrest.
L. R. Baugh (2013)
Genetics 194, 539-555
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882