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Genes & Dev. 25 (17): 1759-1762

Copyright © 2011 by Cold Spring Harbor Laboratory Press.


Wnt signaling meets internal dissent

Elizabeth A. Grove1

Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA

Abstract: In canonical Wnt signaling, β-catenin translocates to the cell nucleus, interacting with Tcf/Lef factors to activate transcription of Wnt target genes. In this issue of Genes & Development, Vacik and colleagues (pp. 1783–1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an internal promoter region that, when activated by Vax2, drives transcription of truncated Tcf7l2 mRNAs. The encoded Tcf7l2 protein binds to DNA, but not β-catenin, and therefore acts as a dominant-negative Wnt antagonist.

Key Words: Vax genes • Sonic hedgehog • canonical Wnt signaling • brain development

1 Correspondence.

E-mail egrove{at}

Article is online at

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