Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Genes & Dev. 25 (17): 1759-1762

Copyright © 2011 by Cold Spring Harbor Laboratory Press.


PERSPECTIVE

Wnt signaling meets internal dissent

Elizabeth A. Grove1

Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA

Abstract: In canonical Wnt signaling, β-catenin translocates to the cell nucleus, interacting with Tcf/Lef factors to activate transcription of Wnt target genes. In this issue of Genes & Development, Vacik and colleagues (pp. 1783–1795) report that a highly conserved sequence in intron 5 of Tcf7l2 conceals an internal promoter region that, when activated by Vax2, drives transcription of truncated Tcf7l2 mRNAs. The encoded Tcf7l2 protein binds to DNA, but not β-catenin, and therefore acts as a dominant-negative Wnt antagonist.

Key Words: Vax genes • Sonic hedgehog • canonical Wnt signaling • brain development


1 Correspondence.

E-mail egrove{at}bsd.uchicago.edu.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.17594311.



To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882