Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated
Degradation of IRS1 and IRS2*
Liangyou
Rui§,
Minsheng
Yuan,
Daniel
Frantz,
Steven
Shoelson, and
Morris F.
White¶
From the ¶ Howard Hughes Medical Institute,
Joslin Diabetes Center, Harvard Medical School,
Boston, Massachusetts 02215
Inflammation associates with peripheral insulin
resistance, which dysregulates nutrient homeostasis and leads to
diabetes.Inflammation induces the expression of SOCS proteins. We showthat SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signalingmolecules for insulin action, for ubiquitin-mediated degradation.SOCS1
or SOCS3 bound both recombinant and endogenous IRS1 andIRS2 and
promoted their ubiquitination and subsequent degradationin multiple
cell types. Mutations in the conserved SOCS box ofSOCS1 abrogated its
interaction with the elongin BC ubiquitin-ligasecomplex without
affecting its binding to IRS1 or IRS2. The SOCS1mutants also failed to
promote the ubiquitination and degradationof either IRS1 or IRS2.
Adenoviral-mediated expression of SOCS1in mouse liver dramatically
reduced hepatic IRS1 and IRS2 proteinlevels and caused glucose
intolerance; by contrast, expressionof the SOCS1 mutants had no
effect. Thus, SOCS-mediated degradationof IRS proteins, presumably via
the elongin BC ubiquitin-ligase,might be a general mechanism of
inflammation-induced insulin resistance,providing a target fortherapy.
Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation.
S. S. Neukamm, J. Ott, S. Dammeier, R. Lehmann, H.-U. Haring, E. Schleicher, and C. Weigert (2013)
J. Biol. Chem.
288, 16403-16415
|Abstract »|Full Text »|PDF »
Stability, delivery and functions of human sperm RNAs at fertilization.
E. Sendler, G. D. Johnson, S. Mao, R. J. Goodrich, M. P. Diamond, R. Hauser, and S. A. Krawetz (2013)
Nucleic Acids Res.
41, 4104-4117
|Abstract »|Full Text »|PDF »
Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients.
L. Q. Jiang, D. E. Duque-Guimaraes, U. F. Machado, J. R. Zierath, and A. Krook (2013)
Diabetes
62, 355-361
|Abstract »|Full Text »|PDF »
Constitutive STAT3 Phosphorylation Contributes to Skeletal Muscle Insulin Resistance in Type 2 Diabetes.
F. Mashili, A. V. Chibalin, A. Krook, and J. R. Zierath (2013)
Diabetes
62, 457-465
|Abstract »|Full Text »|PDF »
Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity.
S. B. Jorgensen, H. M. O'Neill, L. Sylow, J. Honeyman, K. A. Hewitt, R. Palanivel, M. D. Fullerton, L. Oberg, A. Balendran, S. Galic, et al. (2013)
Diabetes
62, 56-64
|Abstract »|Full Text »|PDF »
Suppressors of Cytokine Signaling Promote Fas-Induced Apoptosis through Downregulation of NF-{kappa}B and Mitochondrial Bfl-1 in Leukemic T Cells.
Identification of the Degradation Determinants of Insulin Receptor Substrate 1 for Signaling Cullin-RING E3 Ubiquitin Ligase 7-mediated Ubiquitination.
X. Xu, M. Keshwani, K. Meyer, A. Sarikas, S. Taylor, and Z.-Q. Pan (2012)
J. Biol. Chem.
287, 40758-40766
|Abstract »|Full Text »|PDF »
Selective Hepatic Insulin Resistance, VLDL Overproduction, and Hypertriglyceridemia.
J. D. Sparks, C. E. Sparks, and K. Adeli (2012)
Arterioscler Thromb Vasc Biol
32, 2104-2112
|Abstract »|Full Text »|PDF »
SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.
F. Zadjali, R. Santana-Farre, M. Vesterlund, B. Carow, M. Mirecki-Garrido, I. Hernandez-Hernandez, M. Flodstrom-Tullberg, P. Parini, M. Rottenberg, G. Norstedt, et al. (2012)
FASEB J
26, 3282-3291
|Abstract »|Full Text »|PDF »
Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes.
A. J. Gerrits, E. Gitz, C. A. Koekman, F. L. Visseren, T. W. van Haeften, and J. W. N. Akkerman (2012)
Haematologica
97, 1149-1157
|Abstract »|Full Text »|PDF »
Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3.
N. S. Kalupahana, K. J. Claycombe, and N. Moustaid-Moussa (2011)
Adv Nutr
2, 304-316
|Abstract »|Full Text »|PDF »
Suppression of FoxO1 Activity by Long-Chain Fatty Acyl Analogs.
G. Zatara, R. Hertz, M. Shaked, N. Mayorek, E. Morad, E. Grad, A. Cahan, H. D. Danenberg, T. G. Unterman, and J. Bar-Tana (2011)
Diabetes
60, 1872-1881
|Abstract »|Full Text »|PDF »
Activation of Peroxisome Proliferator-Activated Receptor-{beta}/-{delta} (PPAR-{beta}/-{delta}) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes.
L. Serrano-Marco, R. Rodriguez-Calvo, I. El Kochairi, X. Palomer, L. Michalik, W. Wahli, and M. Vazquez-Carrera (2011)
Diabetes
60, 1990-1999
|Abstract »|Full Text »|PDF »
Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.
T. Wada, M. Hoshino, Y. Kimura, M. Ojima, T. Nakano, D. Koya, H. Tsuneki, and T. Sasaoka (2011)
Am J Physiol Endocrinol Metab
300, E1112-E1123
|Abstract »|Full Text »|PDF »
A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal.
H. Ghanim, C. L. Sia, K. Korzeniewski, T. Lohano, S. Abuaysheh, A. Marumganti, A. Chaudhuri, and P. Dandona (2011)
J. Clin. Endocrinol. Metab.
96, 1409-1414
|Abstract »|Full Text »|PDF »
Chronically Increased S6K1 Is Associated with Impaired IRS1 Signaling in Skeletal Muscle of GDM Women with Impaired Glucose Tolerance Postpartum.
L. A. Barbour, C. E. McCurdy, T. L. Hernandez, and J. E. Friedman (2011)
J. Clin. Endocrinol. Metab.
96, 1431-1441
|Abstract »|Full Text »|PDF »
Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia.
S. Z. Lutz, A. M. Hennige, S. Feil, A. Peter, A. Gerling, J. Machann, S. M. Krober, M. Rath, A. Schurmann, C. Weigert, et al. (2011)
Diabetes
60, 1566-1576
|Abstract »|Full Text »|PDF »
Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907.
L. Fritsche, S. S. Neukamm, R. Lehmann, E. Kremmer, A. M. Hennige, A. Hunder-Gugel, M. Schenk, H.-U. Haring, E. D. Schleicher, and C. Weigert (2011)
Am J Physiol Endocrinol Metab
300, E824-E836
|Abstract »|Full Text »|PDF »
Leptin and the Central Nervous System Control of Glucose Metabolism.
Regulation of Insulin-Stimulated Glucose Uptake in Rat White Adipose Tissue upon Chronic Central Leptin Infusion: Effects on Adiposity.
E. Bonzon-Kulichenko, T. Fernandez-Agullo, E. Molto, R. Serrano, A. Fernandez, M. Ros, J. M. Carrascosa, C. Arribas, C. Martinez, A. Andres, et al. (2011)
Endocrinology
152, 1366-1377
|Abstract »|Full Text »|PDF »
Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance.
J. W. Perfield II, Y. Lee, G. I. Shulman, V. T. Samuel, M. J. Jurczak, E. Chang, C. Xie, P. N. Tsichlis, M. S. Obin, and A. S. Greenberg (2011)
Diabetes
60, 1168-1176
|Abstract »|Full Text »|PDF »
Viral Exploitation of Host SOCS Protein Functions.
Lipocalin-13 Regulates Glucose Metabolism by both Insulin-Dependent and Insulin-Independent Mechanisms.
K. W. Cho, Y. Zhou, L. Sheng, and L. Rui (2011)
Mol. Cell. Biol.
31, 450-457
|Abstract »|Full Text »|PDF »
Suppressor of Cytokine Signaling-3 Is a Glucagon-inducible Inhibitor of PKA Activity and Gluconeogenic Gene Expression in Hepatocytes.
A. M. Gaudy, A. H. Clementi, J. S. Campbell, A. V. Smrcka, and R. A. Mooney (2010)
J. Biol. Chem.
285, 41356-41365
|Abstract »|Full Text »|PDF »
Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk.
M. Manco, L. Putignani, and G. F. Bottazzo (2010)
Endocr. Rev.
31, 817-844
|Abstract »|Full Text »|PDF »
A Novel Domain Mediates Insulin-Induced Proteasomal Degradation of Insulin Receptor Substrate 1 (IRS-1).
S. Boura-Halfon, T. Shuster-Meiseles, A. Beck, K. Petrovich, D. Gurevitch, D. Ronen, and Y. Zick (2010)
Mol. Endocrinol.
24, 2179-2192
|Abstract »|Full Text »|PDF »
Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance.
C. Morel, C. L. Standen, D. Y. Jung, S. Gray, H. Ong, R. A. Flavell, J. K. Kim, and R. J. Davis (2010)
Mol. Cell. Biol.
30, 4616-4625
|Abstract »|Full Text »|PDF »
Discovery and characterization of nutritionally regulated genes associated with muscle growth in Atlantic salmon.
An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol.
H. Ghanim, C. L. Sia, S. Abuaysheh, K. Korzeniewski, P. Patnaik, A. Marumganti, A. Chaudhuri, and P. Dandona (2010)
J. Clin. Endocrinol. Metab.
95, E1-E8
|Abstract »|Full Text »|PDF »
Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor {alpha} expression.
A. R. Moschen, C. Molnar, S. Geiger, I. Graziadei, C. F. Ebenbichler, H. Weiss, S. Kaser, A. Kaser, and H. Tilg (2010)
Gut
59, 1259-1264
|Abstract »|Full Text »|PDF »
Glycogen synthase kinase 3{beta} mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
S. Leng, W. Zhang, Y. Zheng, Z. Liberman, C. J. Rhodes, H. Eldar-Finkelman, and X. J. Sun (2010)
J. Endocrinol.
206, 171-181
|Abstract »|Full Text »|PDF »
Mammary Ductal Growth Is Impaired in Mice Lacking Leptin-Dependent Signal Transducer and Activator of Transcription 3 Signaling.
S. R. Thorn, S. L. Giesy, M. G. Myers Jr., and Y. R. Boisclair (2010)
Endocrinology
151, 3985-3995
|Abstract »|Full Text »|PDF »
Expression of Inflammatory and Insulin Signaling Genes in Adipose Tissue in Response to Elective Surgery.
A. Witasp, L. Nordfors, M. Schalling, J. Nygren, O. Ljungqvist, and A. Thorell (2010)
J. Clin. Endocrinol. Metab.
95, 3460-3469
|Abstract »|Full Text »|PDF »
Adenovirus infection results in alterations of insulin signaling and glucose homeostasis.
S. Jiang, T. A. Gavrikova, A. Pereboev, and J. L. Messina (2010)
Am J Physiol Endocrinol Metab
298, E1295-E1304
|Abstract »|Full Text »|PDF »
Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3.
R. Deopurkar, H. Ghanim, J. Friedman, S. Abuaysheh, C. L. Sia, P. Mohanty, P. Viswanathan, A. Chaudhuri, and P. Dandona (2010)
Diabetes Care
33, 991-997
|Abstract »|Full Text »|PDF »
Establishment of a Mammary Stromal Fibroblastic Cell Line for In Vitro Studies in Mice of Mammary Adipocyte Differentiation.
H. Nakatani, N. Aoki, T. Okajima, D. Nadano, D. Flint, and T. Matsuda (2010)
Biol Reprod
82, 44-53
|Abstract »|Full Text »|PDF »
Interferon {gamma} Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway.
F. C. McGillicuddy, E. H. Chiquoine, C. C. Hinkle, R. J. Kim, R. Shah, H. M. Roche, E. M. Smyth, and M. P. Reilly (2009)
J. Biol. Chem.
284, 31936-31944
|Abstract »|Full Text »|PDF »
Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart.
H. J. Ko, Z. Zhang, D. Y. Jung, J. Y. Jun, Z. Ma, K. E. Jones, S. Y. Chan, and J. K. Kim (2009)
Diabetes
58, 2536-2546
|Abstract »|Full Text »|PDF »
Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.
Signal Transduction Cross Talk Mediated by Jun N-Terminal Kinase-Interacting Protein and Insulin Receptor Substrate Scaffold Protein Complexes.
C. L. Standen, N. J. Kennedy, R. A. Flavell, and R. J. Davis (2009)
Mol. Cell. Biol.
29, 4831-4840
|Abstract »|Full Text »|PDF »
Ubiquitin Ligase Cbl-b Is a Negative Regulator for Insulin-Like Growth Factor 1 Signaling during Muscle Atrophy Caused by Unloading.
R. Nakao, K. Hirasaka, J. Goto, K. Ishidoh, C. Yamada, A. Ohno, Y. Okumura, I. Nonaka, K. Yasutomo, K. M. Baldwin, et al. (2009)
Mol. Cell. Biol.
29, 4798-4811
|Abstract »|Full Text »|PDF »
SH2B1 Enhances Insulin Sensitivity by Both Stimulating the Insulin Receptor and Inhibiting Tyrosine Dephosphorylation of Insulin Receptor Substrate Proteins.
D. L. Morris, K. W. Cho, Y. Zhou, and L. Rui (2009)
Diabetes
58, 2039-2047
|Abstract »|Full Text »|PDF »
Activation of Protein Kinase C{alpha} by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein {beta}-dependent Induction of the SOCS-3 Gene by Cyclic AMP in COS1 Cells.
G. Borland, R. J. Bird, T. M. Palmer, and S. J. Yarwood (2009)
J. Biol. Chem.
284, 17391-17403
|Abstract »|Full Text »|PDF »
High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKK{alpha}/{beta} phosphorylation and decreases PI-3 kinase activity in muscle.
B. B. Yaspelkis III, I. A. Kvasha, and T. Y. Figueroa (2009)
Am J Physiol Regulatory Integrative Comp Physiol
296, R1709-R1715
|Abstract »|Full Text »|PDF »
Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice.
SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases.
J. Elliott, Y. Suessmuth, L. M. Scott, K. Nahlik, M. F. McMullin, S. N. Constantinescu, A. R. Green, and J. A. Johnston (2009)
Haematologica
94, 576-580
|Abstract »|Full Text »|PDF »
IL-6 Cytoprotection in Hyperoxic Acute Lung Injury Occurs via Suppressor of Cytokine Signaling-1-Induced Apoptosis Signal-Regulating Kinase-1 Degradation.
IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting.
L. Zhang, J. Du, Z. Hu, G. Han, P. Delafontaine, G. Garcia, and W. E. Mitch (2009)
J. Am. Soc. Nephrol.
20, 604-612
|Abstract »|Full Text »|PDF »
A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance.
G. Sabio, M. Das, A. Mora, Z. Zhang, J. Y. Jun, H. J. Ko, T. Barrett, J. K. Kim, and R. J. Davis (2008)
Science
322, 1539-1543
|Abstract »|Full Text »|PDF »
Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease.
A. Shah, N. Mehta, and M. P. Reilly (2008)
JPEN J Parenter Enteral Nutr
32, 638-644
|Abstract »|Full Text »|PDF »
Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle.
K. Morino, S. Neschen, S. Bilz, S. Sono, D. Tsirigotis, R. M. Reznick, I. Moore, Y. Nagai, V. Samuel, D. Sebastian, et al. (2008)
Diabetes
57, 2644-2651
|Abstract »|Full Text »|PDF »
Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation.
X. Huang, D. J. Moore, R. J. Ketchum, C. S. Nunemaker, B. Kovatchev, A. L. McCall, and K. L. Brayman (2008)
Endocr. Rev.
29, 603-630
|Abstract »|Full Text »|PDF »
Regulation of the O-Linked {beta}-N-Acetylglucosamine Transferase by Insulin Signaling.
S. A. Whelan, M. D. Lane, and G. W. Hart (2008)
J. Biol. Chem.
283, 21411-21417
|Abstract »|Full Text »|PDF »
Chlorpromazine attenuates pancreatic {beta}-cell function and mass through IRS2 degradation, while exercise partially reverses the attenuation.
S. Park, S. Hong, J. Lee, S. Sung, and S. Kim (2008)
J Psychopharmacol
22, 522-531
|Abstract »|PDF »
Growth Hormone Signaling in Vivo in Human Muscle and Adipose Tissue: Impact of Insulin, Substrate Background, and Growth Hormone Receptor Blockade.
C. Nielsen, L. C. Gormsen, N. Jessen, S. B. Pedersen, N. Moller, S. Lund, and J. O. L. Jorgensen (2008)
J. Clin. Endocrinol. Metab.
93, 2842-2850
|Abstract »|Full Text »|PDF »
Dual Effect of the Adapter Growth Factor Receptor-Bound Protein 14 (Grb14) on Insulin Action in Primary Hepatocytes.
N. Carre, M. Cauzac, J. Girard, and A.-F. Burnol (2008)
Endocrinology
149, 3109-3117
|Abstract »|Full Text »|PDF »
Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells.
X. Liu, M. G. Mameza, Y. S. Lee, C. I. Eseonu, C.-R. Yu, J. J. Kang Derwent, and C. E. Egwuagu (2008)
Diabetes
57, 1651-1658
|Abstract »|Full Text »|PDF »
Regulation of mammary parenchymal growth by the fat pad in prepubertal dairy heifers: role of inflammation-related proteins.
S. R Thorn, S. Purup, M. Vestergaard, K. Sejrsen, M. J Meyer, M. E Van Amburgh, and Y. R Boisclair (2008)
J. Endocrinol.
196, 539-546
|Abstract »|Full Text »|PDF »
HIV-protease inhibitors induce expression of suppressor of cytokine signaling-1 in insulin-sensitive tissues and promote insulin resistance and type 2 diabetes mellitus.
M. J. Carper, W. T. Cade, M. Cam, S. Zhang, A. Shalev, K. E. Yarasheski, and S. Ramanadham (2008)
Am J Physiol Endocrinol Metab
294, E558-E567
|Abstract »|Full Text »|PDF »
Impaired Central Insulin Response in Aged Wistar Rats: Role of Adiposity.
M. Garcia-San Frutos, T. Fernandez-Agullo, A. J. De Solis, A. Andres, C. Arribas, J. M. Carrascosa, and M. Ros (2007)
Endocrinology
148, 5238-5247
|Abstract »|Full Text »|PDF »
Phosphorylation of Irs1 at SER-522 Inhibits Insulin Signaling.
J. Giraud, M. Haas, E. P. Feener, K. D. Copps, X. Dong, S. L. Dunn, and M. F. White (2007)
Mol. Endocrinol.
21, 2294-2302
|Abstract »|Full Text »|PDF »
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.
K. Boyle, P. Egan, S. Rakar, T. A. Willson, I. P. Wicks, D. Metcalf, D. J. Hilton, N. A. Nicola, W. S. Alexander, A. W. Roberts, et al. (2007)
Blood
110, 1466-1474
|Abstract »|Full Text »|PDF »
Mechanisms of obesity-associated insulin resistance: many choices on the menu.
Chronic Tumor Necrosis Factor-{alpha} Treatment Causes Insulin Resistance via Insulin Receptor Substrate-1 Serine Phosphorylation and Suppressor of Cytokine Signaling-3 Induction in 3T3-L1 Adipocytes.
K. Ishizuka, I. Usui, Y. Kanatani, A. Bukhari, J. He, S. Fujisaka, Y. Yamazaki, H. Suzuki, K. Hiratani, M. Ishiki, et al. (2007)
Endocrinology
148, 2994-3003
|Abstract »|Full Text »|PDF »
Reciprocal Regulation of SOCS 1 and SOCS3 Enhances Resistance to Ionizing Radiation in Glioblastoma Multiforme.
H. Zhou, R. Miki, M. Eeva, F. M. Fike, D. Seligson, L. Yang, A. Yoshimura, M. A. Teitell, C. A.M. Jamieson, and N. A. Cacalano (2007)
Clin. Cancer Res.
13, 2344-2353
|Abstract »|Full Text »|PDF »
IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.
S. Brand, J. Dambacher, F. Beigel, K. Zitzmann, M. H. J. Heeg, T. S. Weiss, T. Prufer, T. Olszak, C. J. Steib, M. Storr, et al. (2007)
Am J Physiol Gastrointest Liver Physiol
292, G1019-G1028
|Abstract »|Full Text »|PDF »
Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression.
Y. Kanatani, I. Usui, K. Ishizuka, A. Bukhari, S. Fujisaka, M. Urakaze, T. Haruta, T. Kishimoto, T. Naka, and M. Kobayashi (2007)
Diabetes
56, 795-803
|Abstract »|Full Text »|PDF »
SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses.
S. J. Orr, N. M. Morgan, R. J. Buick, C. R. Boyd, J. Elliott, J. F. Burrows, C. A. Jefferies, P. R. Crocker, and J. A. Johnston (2007)
J. Biol. Chem.
282, 3418-3422
|Abstract »|Full Text »|PDF »
COUNTERPOINT: INTERLEUKIN-6 DOES NOT HAVE A BENEFICIAL ROLE IN INSULIN SENSITIVITY AND GLUCOSE HOMEOSTASIS.
R. A. Mooney (2007)
J Appl Physiol
102, 816-818
|Full Text »|PDF »
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis.
B. K. Pedersen, M. A. Febbraio, and R. A. Mooney (2007)
J Appl Physiol
102, 814-816
|Full Text »|PDF »
Diabetes and Suppressors of Cytokine Signaling Proteins.
S. G. Ronn, N. Billestrup, and T. Mandrup-Poulsen (2007)
Diabetes
56, 541-548
|Full Text »|PDF »
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
S. J. Orr, N. M. Morgan, J. Elliott, J. F. Burrows, C. J. Scott, D. W. McVicar, and J. A. Johnston (2007)
Blood
109, 1061-1068
|Abstract »|Full Text »|PDF »
Interleukin-1{beta}-Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression.
J. Jager, T. Gremeaux, M. Cormont, Y. Le Marchand-Brustel, and J.-F. Tanti (2007)
Endocrinology
148, 241-251
|Abstract »|Full Text »|PDF »
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.
C. N. Lumeng, S. M. Deyoung, and A. R. Saltiel (2007)
Am J Physiol Endocrinol Metab
292, E166-E174
|Abstract »|Full Text »|PDF »
Functional Cross-modulation between SOCS Proteins Can Stimulate Cytokine Signaling.
J. Piessevaux, D. Lavens, T. Montoye, J. Wauman, D. Catteeuw, J. Vandekerckhove, D. Belsham, F. Peelman, and J. Tavernier (2006)
J. Biol. Chem.
281, 32953-32966
|Abstract »|Full Text »|PDF »
Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons..
T. Miao, D. Wu, Y. Zhang, X. Bo, M. C. Subang, P. Wang, and P. M. Richardson (2006)
J. Neurosci.
26, 9512-9519
|Abstract »|Full Text »|PDF »
Exchange Protein Activated by Cyclic AMP (Epac)-Mediated Induction of Suppressor of Cytokine Signaling 3 (SOCS-3) in Vascular Endothelial Cells.
W. A. Sands, H. D. Woolson, G. R. Milne, C. Rutherford, and T. M. Palmer (2006)
Mol. Cell. Biol.
26, 6333-6346
|Abstract »|Full Text »|PDF »
Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation.
F. J. Ramos, P. R. Langlais, D. Hu, L. Q. Dong, and F. Liu (2006)
Am J Physiol Endocrinol Metab
290, E1262-E1266
|Abstract »|Full Text »|PDF »
Insulin and Leptin Induce Glut4 Plasma Membrane Translocation and Glucose Uptake in a Human Neuronal Cell Line by a Phosphatidylinositol 3-Kinase- Dependent Mechanism.
Y. Benomar, N. Naour, A. Aubourg, V. Bailleux, A. Gertler, J. Djiane, M. Guerre-Millo, and M. Taouis (2006)
Endocrinology
147, 2550-2556
|Abstract »|Full Text »|PDF »
Exercise increases SOCS-3 expression in rat skeletal muscle: potential relationship to IL-6 expression.
E. E. Spangenburg, D. A. Brown, M. S. Johnson, and R. L. Moore (2006)
J. Physiol.
572, 839-848
|Abstract »|Full Text »|PDF »
Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance.
H. Shi, B. Cave, K. Inouye, C. Bjorbaek, and J. S. Flier (2006)
Diabetes
55, 699-707
|Abstract »|Full Text »|PDF »
Negative Regulation of Growth Hormone Receptor Signaling.
A. Flores-Morales, C. J. Greenhalgh, G. Norstedt, and E. Rico-Bautista (2006)
Mol. Endocrinol.
20, 241-253
|Abstract »|Full Text »|PDF »
Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
K Inagaki-Ohara, A Sasaki, G Matsuzaki, T Ikeda, M Hotokezaka, K Chijiiwa, M Kubo, H Yoshida, Y Nawa, and A Yoshimura (2006)
Gut
55, 212-219
|Abstract »|Full Text »|PDF »
Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.
T. Ben-Zvi, A. Yayon, A. Gertler, and E. Monsonego-Ornan (2006)
J. Cell Sci.
119, 380-387
|Abstract »|Full Text »|PDF »
Interleukin-1{alpha} Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes.
J. He, I. Usui, K. Ishizuka, Y. Kanatani, K. Hiratani, M. Iwata, A. Bukhari, T. Haruta, T. Sasaoka, and M. Kobayashi (2006)
Mol. Endocrinol.
20, 114-124
|Abstract »|Full Text »|PDF »
The Emerging Role of the COP9 Signalosome in Cancer.
Insulin-Like Growth Factor I Induces Preferential Degradation of Insulin Receptor Substrate-2 through the Phosphatidylinositol 3-Kinase Pathway in Human Neuroblastoma Cells.
B. Kim, C. M. van Golen, and E. L. Feldman (2005)
Endocrinology
146, 5350-5357
|Abstract »|Full Text »|PDF »
Role of the Cytokine-induced SH2 Domain-containing Protein CIS in Growth Hormone Receptor Internalization.
JNK and Tumor Necrosis Factor-{alpha} Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes.
M. T. A. Nguyen, H. Satoh, S. Favelyukis, J. L. Babendure, T. Imamura, J. I. Sbodio, J. Zalevsky, B. I. Dahiyat, N.-W. Chi, and J. M. Olefsky (2005)
J. Biol. Chem.
280, 35361-35371
|Abstract »|Full Text »|PDF »
SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation.
G. M. Tannahill, J. Elliott, A. C. Barry, L. Hibbert, N. A. Cacalano, and J. A. Johnston (2005)
Mol. Cell. Biol.
25, 9115-9126
|Abstract »|Full Text »|PDF »
Physical activity and modulation of systemic low-level inflammation.
JAK/STAT3 Pathway Is Involved in Survival of Neurons in Response to Insulin-like Growth Factor and Negatively Regulated by Suppressor of Cytokine Signaling-3.
A. Yadav, A. Kalita, S. Dhillon, and K. Banerjee (2005)
J. Biol. Chem.
280, 31830-31840
|Abstract »|Full Text »|PDF »
Mechanisms of SOCS3 Phosphorylation upon Interleukin-6 Stimulation: CONTRIBUTIONS OF Src- AND RECEPTOR-TYROSINE KINASES.
U. Sommer, C. Schmid, R. M. Sobota, U. Lehmann, N. J. Stevenson, J. A. Johnston, F. Schaper, P. C. Heinrich, and S. Haan (2005)
J. Biol. Chem.
280, 31478-31488
|Abstract »|Full Text »|PDF »
E. Jamieson, M. M. W. Chong, G. R. Steinberg, V. Jovanovska, B. C. Fam, D. V. R. Bullen, Y. Chen, B. E. Kemp, J. Proietto, T. W. H. Kay, et al. (2005)
J. Biol. Chem.
280, 31516-31521
|Abstract »|Full Text »|PDF »
Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance.
J. K. Kim, H.-J. Kim, S.-Y. Park, A. Cederberg, R. Westergren, D. Nilsson, T. Higashimori, Y.-R. Cho, Z.-X. Liu, J. Dong, et al. (2005)
Diabetes
54, 1657-1663
|Abstract »|Full Text »|PDF »
§,
