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J. Biol. Chem. 277 (50): 48122-48129

© 2002 by The American Society for Biochemistry and Molecular Biology, Inc.

A Novel Host-Parasite Lipid Cross-talk

SCHISTOSOMAL LYSO-PHOSPHATIDYLSERINE ACTIVATES TOLL-LIKE RECEPTOR 2 AND AFFECTS IMMUNE POLARIZATION*

Desiree van der Kleij{ddagger}§, Eicke Latz||, Jos F. H. M. Brouwers§, Yvonne C. M. Kruize{ddagger}, Marion Schmitz§, Evelyn A. Kurt-Jones, Terje Espevik**, Esther C. de Jong{ddagger}, Martien L. Kapsenberg{ddagger}, Douglas T. Golenbock, Aloysius G. M. Tielens§, , and Maria Yazdanbakhsh{ddagger}§§

From the {ddagger}Department of Parasitology, Leiden University Medical Center, 2300RC Leiden, The Netherlands, §Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands, Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, Massachusetts 01655, **Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, 7489 Trondheim, Norway, and {ddagger}Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands

ABSTRACT Back to Top

Abstract: Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology.


Received for publication July 11, 2002. Revision received August 23, 2002.


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