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J. Cell Biol. 170 (2): 169-171

Copyright © 2005 by the Rockefeller University Press.


It's HIP to be a hub

new trends for old-fashioned proteins

Manuela Vecchi1, and Pier Paolo Di Fiore1,2,3

1 Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) di Oncologia Molecolare, 20139 Milan, Italy
2 Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, 20122 Milan, Italy
3 Istituto Europeo di Oncologia, 20141 Milan, Italy

Correspondence to Pier Paolo Di Fiore: pierpaolo.difiore{at}

Abstract Back to Top

Abstract: Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.

Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1.
M. Banerjee, M. Datta, P. Majumder, D. Mukhopadhyay, and N. P. Bhattacharyya (2010)
Nucleic Acids Res. 38, 878-892
   Abstract »    Full Text »    PDF »
Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo.
E. Trushina, R. D. Singh, R. B. Dyer, S. Cao, V. H. Shah, R. G. Parton, R. E. Pagano, and C. T. McMurray (2006)
Hum. Mol. Genet. 15, 3578-3591
   Abstract »    Full Text »    PDF »

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