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J. Cell Biol. 181 (2): 181-183

Copyright © 2008 by the Rockefeller University Press.

Comment

Spinophilin and the immune synapse

Brian Seed1, and Ramnik Xavier2

1 Department of Pediatrics and 2 Department of Medicine, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114

Correspondence to B. Seed: bseed{at}ccib.mgh.harvard.edu

Abstract: Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J. Unternaehrer, A. Jiang, J.-S. Shin, L. Delamarre, P. Allen, and I. Mellman. 2008. J. Cell Biol. 181:203–211) have captured a remarkable polarization of the cellular architecture of dendritic cells presenting an antigen to T cells.

Abbreviation used in this paper: GPCR, G protein–coupled receptor.

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)