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J. Cell Biol. 183 (5): 757-759

Copyright © 2008 by the Rockefeller University Press.


Comment

Parkin mitochondria in the autophagosome

Heidi M. McBride

University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada

Correspondence to Heidi M. McBride: hmcbride{at}ottawaheart.ca

Abstract: Narendra et al. (see p. 795 of this issue) have made an exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's disease (PD). Through an elegant series of high-resolution imaging experiments, they are the first to provide evidence that the PARK2 gene product Parkin is selectively recruited to damaged or uncoupled mitochondria. This recruitment leads to the clearance of the organelles through the autophagosome, demonstrating a primary function for Parkin in the regulation of mitochondrial turnover. This work significantly increases our understanding of PD and provides a new framework for the development of therapeutic interventions.

© 2008 McBride This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


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