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J. Cell Biol. 193 (3): 431-433

Copyright © 2011 by the Rockefeller University Press.


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Generating a Wnt switch: it’s all about the right dosage

Hans A. Kestler1, and Michael Kühl2

1 Institute for Neural Information Processing and 2 Institute for Biochemistry and Molecular Biology, Ulm University, D-89081 Ulm, Germany

Correspondence to Michael Kühl: michael.kuehl{at}uni-ulm.de

Abstract: Wnt proteins can activate different branches of the Wnt signaling pathway, raising the question of specificity. In this issue, Nalesso et al. (2011. J. Cell Biol. doi:10.1083/jcb.201011051) provide an answer to this conundrum by showing that different concentrations of Wnt ligands can elicit different intracellular responses. These findings not only provide new insights into the molecular mechanisms underlying Wnt signaling, but also indicate how Wnt gradients might contribute to tissue patterning during embryogenesis.




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