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J. Cell Biol. 197 (3): 347-349

Copyright © 2012 by the Rockefeller University Press.


Cell migration: Fibroblasts find a new way to get ahead

Michael Sixt

Institute of Science and Technology Austria, A-3400 Klosterneuburg, Austria

Correspondence to Michael Sixt: sixt{at}

Abstract: Fibroblasts migrate on two-dimensional (2D) surfaces by forming lamellipodia—actin-rich extensions at the leading edge of the cell that have been well characterized. In this issue, Petrie et al. (2012. J. Cell Biol. show that in some 3D environments, including tissue explants, fibroblasts project different structures, termed lobopodia, at the leading edge. Lobopodia still assemble focal adhesions; however, similar to membrane blebs, they are driven by actomyosin contraction and do not accumulate active Rac, Cdc42, and phosphatidylinositol 3-kinases.

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.
W.-C. Hung, S.-H. Chen, C. D. Paul, K. M. Stroka, Y.-C. Lo, J. T. Yang, and K. Konstantopoulos (2013)
J. Cell Biol. 202, 807-824
   Abstract »    Full Text »    PDF »
Actin stress fibre subtypes in mesenchymal-migrating cells.
T. Vallenius (2013)
Open Bio 3, 130001
   Abstract »    Full Text »    PDF »

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