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J. Cell Biol. 197 (3): 347-349

Copyright © 2012 by the Rockefeller University Press.

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Cell migration: Fibroblasts find a new way to get ahead

Michael Sixt

Institute of Science and Technology Austria, A-3400 Klosterneuburg, Austria

Correspondence to Michael Sixt: sixt{at}ist.ac.at

Abstract: Fibroblasts migrate on two-dimensional (2D) surfaces by forming lamellipodia—actin-rich extensions at the leading edge of the cell that have been well characterized. In this issue, Petrie et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201201124) show that in some 3D environments, including tissue explants, fibroblasts project different structures, termed lobopodia, at the leading edge. Lobopodia still assemble focal adhesions; however, similar to membrane blebs, they are driven by actomyosin contraction and do not accumulate active Rac, Cdc42, and phosphatidylinositol 3-kinases.

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