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J. Exp. Med. 206 (11): 2455-2467

Copyright © 2009 by the Rockefeller University Press.

Article

Mast cell–derived particles deliver peripheral signals to remote lymph nodes

Christian A. Kunder1, Ashley L. St. John2, Guojie Li1, Kam W. Leong3, Brent Berwin6, Herman F. Staats1,2,4, , and Soman N. Abraham1,2,5,7

1 Department of Pathology, 2 Department of Immunology, 3 Department of Biomedical Engineering, 4 Department of Medicine, and 5 Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710
6 Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03755
7 Duke–National University of Singapore, Graduate Medical School, Singapore 169857

CORRESPONDENCE Soman N. Abraham: soman.abraham{at}duke.edu

Abstract: During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues.

C.A. Kunder and A.L. St. John contributed equally to this paper.

Abbreviations: BMMC, BM-derived MC • DLN, draining LN • HEV, high endothelial venule • MC, mast cell • SEM, scanning electron micrograph

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