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PLANT CELL 19 (8): 2470-2483

Copyright © 2007 by the American Society of Plant Physiologists.

A Downstream Mediator in the Growth Repression Limb of the Jasmonate Pathway[W],[OA]

Yuanxin Yana,1, Stéphanie Stolza, Aurore Chételata, Philippe Reymonda, Marco Pagnib, Lucie Dubugnona, and Edward E. Farmera,2

a Department of Plant Molecular Biology, University of Lausanne, Biophore, CH-1015 Lausanne, Switzerland
b Swiss Institute of Bioinformatics, Vital-IT Group, Génopode, CH-1015 Lausanne, Switzerland

2 Address correspondence to edward.farmer{at}

Abstract: Wounding plant tissues initiates large-scale changes in transcription coupled to growth arrest, allowing resource diversion for defense. These processes are mediated in large part by the potent lipid regulator jasmonic acid (JA). Genes selected from a list of wound-inducible transcripts regulated by the jasmonate pathway were overexpressed in Arabidopsis thaliana, and the transgenic plants were then assayed for sensitivity to methyl jasmonate (MeJA). When grown in the presence of MeJA, the roots of plants overexpressing a gene of unknown function were longer than those of wild-type plants. When transcript levels for this gene, which we named JASMONATE-ASSOCIATED1 (JAS1), were reduced by RNA interference, the plants showed increased sensitivity to MeJA and growth was inhibited. These gain- and loss-of-function assays suggest that this gene acts as a repressor of JA-inhibited growth. An alternative transcript from the gene encoding a second protein isoform with a longer C terminus failed to repress jasmonate sensitivity. This identified a conserved C-terminal sequence in JAS1 and related genes, all of which also contain Zim motifs and many of which are jasmonate-regulated. Both forms of JAS1 were found to localize to the nucleus in transient expression assays. Physiological tests of growth responses after wounding were consistent with the fact that JAS1 is a repressor of JA-regulated growth retardation.

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   Abstract »    Full Text »    PDF »
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PNAS 110, 9197-9198
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Ann. Bot. 111, 1021-1058
   Abstract »    Full Text »    PDF »
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J. E. Moreno, C. Shyu, M. L. Campos, L. C. Patel, H. S. Chung, J. Yao, S. Y. He, and G. A. Howe (2013)
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Mol Plant 6, 686-703
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Plant Physiology 160, 145-155
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L. Gutierrez, G. Mongelard, K. Flokova, D. I. Pacurar, O. Novak, P. Staswick, M. Kowalczyk, M. Pacurar, H. Demailly, G. Geiss, et al. (2012)
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Y. Oh, I. T. Baldwin, and I. Galis (2012)
Plant Physiology 159, 769-788
   Abstract »    Full Text »    PDF »
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D.-L. Yang, J. Yao, C.-S. Mei, X.-H. Tong, L.-J. Zeng, Q. Li, L.-T. Xiao, T.-p. Sun, J. Li, X.-W. Deng, et al. (2012)
PNAS 109, E1192-E1200
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Y. Yan, S. Christensen, T. Isakeit, J. Engelberth, R. Meeley, A. Hayward, R. J. N. Emery, and M. V. Kolomiets (2012)
PLANT CELL 24, 1420-1436
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I. Cerrudo, M. M. Keller, M. D. Cargnel, P. V. Demkura, M. de Wit, M. S. Patitucci, R. Pierik, C. M. J. Pieterse, and C. L. Ballare (2012)
Plant Physiology 158, 2042-2052
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Low antioxidant concentrations impact on multiple signalling pathways in Arabidopsis thaliana partly through NPR1.
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Cytochromes P450 CYP94C1 and CYP94B3 Catalyze Two Successive Oxidation Steps of Plant Hormone Jasmonoyl-isoleucine for Catabolic Turnover.
T. Heitz, E. Widemann, R. Lugan, L. Miesch, P. Ullmann, L. Desaubry, E. Holder, B. Grausem, S. Kandel, M. Miesch, et al. (2012)
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C. Shyu, P. Figueroa, C. L. DePew, T. F. Cooke, L. B. Sheard, J. E. Moreno, L. Katsir, N. Zheng, J. Browse, and G. A. Howe (2012)
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H.-B. Zhang, M. T. Bokowiec, P. J. Rushton, S.-C. Han, and M. P. Timko (2012)
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A. M. Adio, C. L. Casteel, M. De Vos, J. H. Kim, V. Joshi, B. Li, C. Juery, J. Daron, D. J. Kliebenstein, and G. Jander (2011)
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The Basic Helix-Loop-Helix Transcription Factor MYC2 Directly Represses PLETHORA Expression during Jasmonate-Mediated Modulation of the Root Stem Cell Niche in Arabidopsis.
Q. Chen, J. Sun, Q. Zhai, W. Zhou, L. Qi, L. Xu, B. Wang, R. Chen, H. Jiang, J. Qi, et al. (2011)
PLANT CELL 23, 3335-3352
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   Abstract »    Full Text »    PDF »
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Plant Physiology 157, 341-354
   Abstract »    Full Text »    PDF »
Jasmonate Controls Polypeptide Patterning in Undamaged Tissue in Wounded Arabidopsis Leaves.
A. Gfeller, K. Baerenfaller, J. Loscos, A. Chetelat, S. Baginsky, and E. E. Farmer (2011)
Plant Physiology 156, 1797-1807
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Z. Zhu, F. An, Y. Feng, P. Li, L. Xue, M. A, Z. Jiang, J.-M. Kim, T. K. To, W. Li, et al. (2011)
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E. W. Chehab, S. Kim, T. Savchenko, D. Kliebenstein, K. Dehesh, and J. Braam (2011)
Plant Physiology 156, 770-778
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PLANT CELL 23, 1795-1814
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Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.
Y. Niu, P. Figueroa, and J. Browse (2011)
J. Exp. Bot. 62, 2143-2154
   Abstract »    Full Text »    PDF »
The Arabidopsis bHLH Transcription Factors MYC3 and MYC4 Are Targets of JAZ Repressors and Act Additively with MYC2 in the Activation of Jasmonate Responses.
P. Fernandez-Calvo, A. Chini, G. Fernandez-Barbero, J.-M. Chico, S. Gimenez-Ibanez, J. Geerinck, D. Eeckhout, F. Schweizer, M. Godoy, J. M. Franco-Zorrilla, et al. (2011)
PLANT CELL 23, 701-715
   Abstract »    Full Text »    PDF »
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V. Tzin and G. Galili (2010)
Mol Plant 3, 956-972
   Abstract »    Full Text »    PDF »
Ubiquitin Ligase-Coupled Receptors Extend Their Reach to Jasmonate.
G. A. Howe (2010)
Plant Physiology 154, 471-474
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Kinetic Basis for the Conjugation of Auxin by a GH3 Family Indole-acetic Acid-Amido Synthetase.
Q. Chen, C. S. Westfall, L. M. Hicks, S. Wang, and J. M. Jez (2010)
J. Biol. Chem. 285, 29780-29786
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Arabidopsis GLUTATHIONE REDUCTASE1 Plays a Crucial Role in Leaf Responses to Intracellular Hydrogen Peroxide and in Ensuring Appropriate Gene Expression through Both Salicylic Acid and Jasmonic Acid Signaling Pathways.
A. Mhamdi, J. Hager, S. Chaouch, G. Queval, Y. Han, L. Taconnat, P. Saindrenan, H. Gouia, E. Issakidis-Bourguet, J.-P. Renou, et al. (2010)
Plant Physiology 153, 1144-1160
   Abstract »    Full Text »    PDF »
Jasmonic Acid and Ethylene Modulate Local Responses to Wounding and Simulated Herbivory in Nicotiana attenuata Leaves.
N. Onkokesung, I. Galis, C. C. von Dahl, K. Matsuoka, H.-P. Saluz, and I. T. Baldwin (2010)
Plant Physiology 153, 785-798
   Abstract »    Full Text »    PDF »
Jasmonate and Phytochrome A Signaling in Arabidopsis Wound and Shade Responses Are Integrated through JAZ1 Stability.
F. Robson, H. Okamoto, E. Patrick, S.-R. Harris, C. Wasternack, C. Brearley, and J. G. Turner (2010)
PLANT CELL 22, 1143-1160
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Chloroplastic Phosphoadenosine Phosphosulfate Metabolism Regulates Basal Levels of the Prohormone Jasmonic Acid in Arabidopsis Leaves.
V. M. Rodriguez, A. Chetelat, P. Majcherczyk, and E. E. Farmer (2010)
Plant Physiology 152, 1335-1345
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Arabidopsis Jasmonate Signaling Pathway.
A. Gfeller, R. Liechti, and E. E. Farmer (2010)
Science Signaling 3, cm4
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Velocity Estimates for Signal Propagation Leading to Systemic Jasmonic Acid Accumulation in Wounded Arabidopsis.
G. Glauser, L. Dubugnon, S. A. R. Mousavi, S. Rudaz, J.-L. Wolfender, and E. E. Farmer (2009)
J. Biol. Chem. 284, 34506-34513
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A Leaky Mutation in DWARF4 Reveals an Antagonistic Role of Brassinosteroid in the Inhibition of Root Growth by Jasmonate in Arabidopsis.
C. Ren, C. Han, W. Peng, Y. Huang, Z. Peng, X. Xiong, Q. Zhu, B. Gao, and D. Xie (2009)
Plant Physiology 151, 1412-1420
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Expression of the Arabidopsis jasmonate signalling repressor JAZ1/TIFY10A is stimulated by auxin.
W. Grunewald, B. Vanholme, L. Pauwels, E. Plovie, D. Inze, G. Gheysen, and A. Goossens (2009)
EMBO Rep. 10, 923-928
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The Arabidopsis CORONATINE INSENSITIVE1 Protein Is a Jasmonate Receptor.
J. Yan, C. Zhang, M. Gu, Z. Bai, W. Zhang, T. Qi, Z. Cheng, W. Peng, H. Luo, F. Nan, et al. (2009)
PLANT CELL 21, 2220-2236
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The Tryptophan Conjugates of Jasmonic and Indole-3-Acetic Acids Are Endogenous Auxin Inhibitors.
P. E. Staswick (2009)
Plant Physiology 150, 1310-1321
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Arabidopsis GH3.12 (PBS3) Conjugates Amino Acids to 4-Substituted Benzoates and Is Inhibited by Salicylate.
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J. Biol. Chem. 284, 9742-9754
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Ecological modulation of plant defense via phytochrome control of jasmonate sensitivity.
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PNAS 106, 4935-4940
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J. Browse (2009)
Science Signaling 2, pe9
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Indirect suppression of photosynthesis on individual leaves by arthropod herbivory.
P. D. Nabity, J. A. Zavala, and E. H. DeLucia (2009)
Ann. Bot. 103, 655-663
   Abstract »    Full Text »    PDF »
Detritivorous crustaceans become herbivores on jasmonate-deficient plants.
E. E. Farmer and L. Dubugnon (2009)
PNAS 106, 935-940
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Thigmomorphogenesis: a complex plant response to mechano-stimulation.
E. W. Chehab, E. Eich, and J. Braam (2009)
J. Exp. Bot. 60, 43-56
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A Critical Role for the TIFY Motif in Repression of Jasmonate Signaling by a Stabilized Splice Variant of the JASMONATE ZIM-Domain Protein JAZ10 in Arabidopsis.
H. S. Chung and G. A. Howe (2009)
PLANT CELL 21, 131-145
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Plant hormone receptors: new perceptions.
A. K. Spartz and W. M. Gray (2008)
Genes & Dev. 22, 2139-2148
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Mechanostimulation of Medicago truncatula leads to enhanced levels of jasmonic acid.
C. Tretner, U. Huth, and B. Hause (2008)
J. Exp. Bot. 59, 2847-2856
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Jasmonate-Induced Nicotine Formation in Tobacco is Mediated by Tobacco COI1 and JAZ Genes.
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Plant Cell Physiol. 49, 1003-1012
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Spatial and Temporal Dynamics of Jasmonate Synthesis and Accumulation in Arabidopsis in Response to Wounding.
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COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine.
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PNAS 105, 7100-7105
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Jasmonate Signaling: Toward an Integrated View.
K. Kazan and J. M. Manners (2008)
Plant Physiology 146, 1459-1468
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New Weapons and a Rapid Response against Insect Attack.
J. Browse and G. A. Howe (2008)
Plant Physiology 146, 832-838
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General Detoxification and Stress Responses Are Mediated by Oxidized Lipids through TGA Transcription Factors in Arabidopsis.
S. Mueller, B. Hilbert, K. Dueckershoff, T. Roitsch, M. Krischke, M. J. Mueller, and S. Berger (2008)
PLANT CELL 20, 768-785
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Regulation and Function of Arabidopsis JASMONATE ZIM-Domain Genes in Response to Wounding and Herbivory.
H. S. Chung, A. J.K. Koo, X. Gao, S. Jayanty, B. Thines, A. D. Jones, and G. A. Howe (2008)
Plant Physiology 146, 952-964
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The JAZ Proteins Link Jasmonate Perception with Transcriptional Changes.
A. Santner and M. Estelle (2007)
PLANT CELL 19, 3839-3842
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