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PNAS 100 (24): 14397-14402

Copyright © 2003 by the National Academy of Sciences.

BIOLOGICAL SCIENCES / NEUROSCIENCE

Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses

Kimberly A. Moore, Roger A. Nicoll*, and Dietmar Schmitz{dagger}

Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143

Contributed by Roger A. Nicoll, September 10, 2003

Abstract: The release properties of synapses in the central nervous system vary greatly, not only across anatomically distinct types of synapses but also among the same class of synapse. This variation manifests itself in large part by differences in the probability of transmitter release, which affects such activity-dependent presynaptic forms of plasticity as paired-pulse facilitation and frequency facilitation. This heterogeneity in presynaptic function reflects differences in the intrinsic properties of the synaptic terminal and the activation of presynaptic neurotransmitter receptors. Here we show that the unique presynaptic properties of the hippocampal mossy fiber synapse are largely imparted onto the synapse by the continuous local action of extracellular adenosine at presynaptic A1 adenosine receptors, which maintains a low basal probability of transmitter release.

* To whom correspondence should be addressed. E-mail: nicoll{at}cmp.ucsf.edu.

{dagger} Present address: Neuroscience Research Center at the Charite, Humboldt University, Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.

Abbreviations: PPF, paired-pulse facilitation; A/C, associational/commissural; LTP, long-term potentiation; ACSF, artificial cerebrospinal fluid; fEPSP, field excitatory postsynaptic potential; LCCG-1, (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine; DPCPX, 8-cyclopentyl-1,3-dipropylxanthine; NEM, N-ethylmaleimide; CCPA, 2-chloro-N6-cyclopentyladenosine; GABAB, {gamma}-aminobutyric acid type B; mGluR, metabotropic glutamate receptor.

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