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Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
Yong Zhu,,
Jason Bond, and
Peter Thomas,
Marine Science Institute, University of Texas at Austin, 750 Channel View Drive, Port Aransas, TX 78373; and Department of Biology, East Carolina University, 1000 East Fifth Street, Greenville, NC 27858
Received for publication October 9, 2002.
Abstract:
Recently we discovered a previously uncharacterized gene withthe characteristics of a membrane progestin receptor (mPR) ina fish model, spotted seatrout. Here, we report the identification,cloning, and characteristics of other members of this hithertounknown family of putative mPRs from several vertebrate species,including human, mouse, pig, Xenopus, zebrafish, and Fugu, withhighly conserved nucleotide and deduced amino acid sequencesand similar structures to the spotted seatrout mPR. The 13 vertebrategenes identified seem to belong to an unknown gene family. Phylogeneticanalysis indicates these cDNAs comprise three distinct groups(named α, β, and ) within this gene family. Structuralanalyses of the translated cDNAs suggest they encode membraneproteins with seven transmembrane domains. The transcript sizesof the human α, β, and putative mPR mRNAs variedfrom 2.8 to 5.8 kb and showed distinct distributions in reproductive,neural, kidney and intestinal tissues, respectively. Recombinanthuman α, , and mouse β proteins produced in an Escherichiacoli expression system demonstrated high affinity (Kd = 20–30nM) saturable binding for progesterone. Further analysis ofbinding to the -subtype revealed binding was specific for progestinsand was displaceable, with rapid rates of association and dissociation(t1/2 = 2–8 min). These results suggest this is a newfamily of steroid receptors unrelated to nuclear steroid receptors,but instead having characteristics of G protein-coupled receptors.
To whom correspondence should be addressed. E-mail: thomas{at}utmsi.utexas.edu.
Edited by Ronald W. Estabrook, University of Texas SouthwesternMedical Center, Dallas, TX, and approved December 17, 2002
This paper was submitted directly (Track II) to the PNAS office.
Data deposition: The sequences reported in this paper have beendeposited in the GenBank database (accession nos. AF315615–AF315620 and AY149119–AY1419121).
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|Abstract »|Full Text »|PDF »
Endocrine-like Signaling in Cnidarians: Current Understanding and Implications for Ecophysiology.
To whom correspondence should be addressed. E-mail: thomas{at}utmsi.utexas.edu. 
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Jason Bond
) within this gene family. Structural analyses of the translated cDNAs suggest they encode membrane proteins with seven transmembrane domains. The transcript sizes of the human α, β, and 
