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Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1)
Daniel N. Cox,
Lily Yeh Jan, and
Yuh-Nung Jan *
Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, 1550 Fourth Street, San Francisco, CA 94143-0725
Contributed by Yuh-Nung Jan, July 24, 2004
Development of both dendrites and axons is important for theformation of neuronal circuits, because dendrites receive informationand the axon is responsible for sending signals. In the pastdecade, extensive studies have revealed many molecules underlyingaxonal outgrowth and pathfinding. In contrast, much less isknown about the molecular mechanisms that control dendrite development.Here we report the identification of an evolutionarily conservedIg superfamily member, dendrite arborization and synapse maturation1 (Dasm1), which plays a critical role in dendrite development.Dasm1 contains five Ig domains and two fibronectin III domainsin the extracellular N terminus, a single transmembrane domain,and an intracellular C-terminal tail with a type I PDZ domainbinding motif at the end. It is highly expressed in the brainand localized at the dendrites. Suppression of Dasm1 expressionin hippocampal neurons via RNA interference or expression ofDasm1 without its cytoplasmic tail specifically impairs dendrite,but not axon, outgrowth. Together with its orthologues in otherspecies, Dasm1 defines a family of molecules likely involvedspecifically in dendrite arborization.