Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

PNAS 101 (6): 1764-1768

Copyright © 2004 by the National Academy of Sciences.

Neuroscience

Notch is required for long-term memory in Drosophila

Asaf Presente, Randy S. Boyles, Christine N. Serway, J. Steven de Belle, and Andrew J. Andres *

Department of Biological Sciences, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154-4004

Communicated by Howard A. Nash, National Institutes of Health, Bethesda, MD, December 11, 2003

Received for publication October 10, 2003.

Abstract: A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructure. Simultaneously, Presenilin (Psn) was identified both as a key mediator of Notch signaling and as a site of genetic lesions that cause early-onset Alzheimer's disease. Here we demonstrate that Notch loss of function produces memory deficits in Drosophila melanogaster. The effects are specific to long-term memory, which is thought to depend on ultrastructural remodeling. We propose that Notch plays an important role in the neural plasticity underlying consolidated memory.

Abbreviations: RNAi, RNA interference; PI, performance index; CS, Canton Special; UAS, upstream activating sequence; MB, mushroom body; AD, Alzheimer's disease.

* To whom correspondence should be addressed. E-mail: andrew.andres{at}ccmail.nevada.edu.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Presenilins and {gamma}-Secretase: Structure, Function, and Role in Alzheimer Disease.
B. De Strooper, T. Iwatsubo, and M. S. Wolfe (2012)
Cold Spring Harb Perspect Med 2, a006304
   Abstract »    Full Text »    PDF »
Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing.
I. Becam, N. Rafel, X. Hong, S. M. Cohen, and M. Milan (2011)
Development 138, 3781-3789
   Abstract »    Full Text »    PDF »
Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila.
T. Copf, V. Goguel, A. Lampin-Saint-Amaux, N. Scaplehorn, and T. Preat (2011)
PNAS 108, 8059-8064
   Abstract »    Full Text »    PDF »
Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior.
L. C. Griffith and A. Ejima (2009)
Learn. Mem. 16, 743-750
   Abstract »    Full Text »    PDF »
ben Functions with Scamp during Synaptic Transmission and Long-Term Memory Formation in Drosophila.
H. Zhao, X. Zheng, X. Yuan, L. Wang, X. Wang, Y. Zhong, Z. Xie, and T. Tully (2009)
J. Neurosci. 29, 414-424
   Abstract »    Full Text »    PDF »
The Drosophila cell adhesion molecule Klingon is required for long-term memory formation and is regulated by Notch.
M. Matsuno, J. Horiuchi, T. Tully, and M. Saitoe (2009)
PNAS 106, 310-315
   Abstract »    Full Text »    PDF »
Neuralized is expressed in the {alpha}/{beta} lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation.
E. Pavlopoulos, M. Anezaki, and E. M. C. Skoulakis (2008)
PNAS 105, 14674-14679
   Abstract »    Full Text »    PDF »
Notch signalling is required for both dauer maintenance and recovery in C. elegans.
J. Ouellet, S. Li, and R. Roy (2008)
Development 135, 2583-2592
   Abstract »    Full Text »    PDF »
Receptor-Like Tyrosine Phosphatase PTP10D Is Required for Long-Term Memory in Drosophila.
M. Qian, G. Pan, L. Sun, C. Feng, Z. Xie, T. Tully, and Y. Zhong (2007)
J. Neurosci. 27, 4396-4402
   Abstract »    Full Text »    PDF »
Requirement of Akt to Mediate Long-Term Synaptic Depression in Drosophila.
H.-F. Guo and Y. Zhong (2006)
J. Neurosci. 26, 4004-4014
   Abstract »    Full Text »    PDF »
Acute {gamma}-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease.
T. A. Comery, R. L. Martone, S. Aschmies, K. P. Atchison, G. Diamantidis, X. Gong, H. Zhou, A. F. Kreft, M. N. Pangalos, J. Sonnenberg-Reines, et al. (2005)
J. Neurosci. 25, 8898-8902
   Abstract »    Full Text »    PDF »
A clock gene, period, plays a key role in long-term memory formation in Drosophila.
T. Sakai, T. Tamura, T. Kitamoto, and Y. Kidokoro (2004)
PNAS 101, 16058-16063
   Abstract »    Full Text »    PDF »
Notch signaling in Drosophila long-term memory formation.
X. Ge, F. Hannan, Z. Xie, C. Feng, T. Tully, H. Zhou, Z. Xie, and Y. Zhong (2004)
PNAS 101, 10172-10176
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882