Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Tumor necrosis factor (TNF) is a major mediator of
apoptosis as well as inflammation and immunity, and it has been
implicatedin the pathogenesis of a wide spectrum of human diseases,
includingsepsis, diabetes, cancer, osteoporosis, multiple sclerosis,
rheumatoidarthritis, and inflammatory bowel diseases. The interaction
ofTNF with TNF receptor-1 (TNF-R1) activates several signal
transductionpathways. A common feature of each pathway is the
TNF-inducedformation of a multiprotein signaling complex at the cell
membrane.Over the past decade, many of the components and mechanisms
ofthese signaling pathways have been elucidated. We provide an
overviewof current knowledge of TNF signaling and introduce an STKE
ConnectionsMap that depicts a canonical view of this process.
Tularik Inc., Two Corporate Drive, South San Francisco, CA 94080, USA.
*
To whom correspondence should be addressed. E-mail:
goeddel{at}tularik.com
The editors suggest the following Related Resources on Science sites:
In Science Signaling
DATABASE OF CELL SIGNALING
Tumor Necrosis Factor Pathway
Guoqing Chen and David V. Goeddel Sci. Signal. (Connections Map Pathway), http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7107 |Canonical Pathway »|Schematic »
TNF{alpha} shedding and epidermal inflammation are controlled by Jun proteins.
J. Guinea-Viniegra, R. Zenz, H. Scheuch, D. Hnisz, M. Holcmann, L. Bakiri, H. B. Schonthaler, M. Sibilia, and E. F. Wagner (2009)
Genes & Dev.
23, 2663-2674
|Abstract »|Full Text »|PDF »
CCR7-Dependent Stimulation of Survival in Dendritic Cells Involves Inhibition of GSK3{beta}.
C. Escribano, C. Delgado-Martin, and J. L. Rodriguez-Fernandez (2009)
J. Immunol.
183, 6282-6295
|Abstract »|Full Text »|PDF »
NF-{kappa}B activity is constitutively elevated in c-Abl null fibroblasts.
Tumor Necrosis Factor-{alpha}-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter.
K. M. Park, D. I. Yule, and W. J. Bowers (2009)
J. Biol. Chem.
284, 27557-27566
|Abstract »|Full Text »|PDF »
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue.
R. C.M. van Kruijsdijk, E. van der Wall, and F. L.J. Visseren (2009)
Cancer Epidemiol. Biomarkers Prev.
18, 2569-2578
|Abstract »|Full Text »|PDF »
Licochalcone A Potently Inhibits Tumor Necrosis Factor {alpha}-Induced Nuclear Factor-{kappa}B Activation through the Direct Inhibition of I{kappa}B Kinase Complex Activation.
M. Funakoshi-Tago, S. Tanabe, K. Tago, H. Itoh, T. Mashino, Y. Sonoda, and T. Kasahara (2009)
Mol. Pharmacol.
76, 745-753
|Abstract »|Full Text »|PDF »
Cigarette Smoking, STAT4 and TNFRSF1B Polymorphisms, and Systemic Lupus Erythematosus in a Japanese Population.
C. KIYOHARA, M. WASHIO, T. HORIUCHI, Y. TADA, T. ASAMI, S. IDE, T. ATSUMI, G. KOBASHI, and H. TAKAHASHI (2009)
J Rheumatol
36, 2195-2203
|Abstract »|Full Text »|PDF »
Antidepressant Actions of Histone Deacetylase Inhibitors.
H. E. Covington III, I. Maze, Q. C. LaPlant, V. F. Vialou, Y. N. Ohnishi, O. Berton, D. M. Fass, W. Renthal, A. J. Rush III, E. Y. Wu, et al. (2009)
J. Neurosci.
29, 11451-11460
|Abstract »|Full Text »|PDF »
Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation.
M. Kneilling, R. Mailhammer, L. Hultner, T. Schonberger, K. Fuchs, M. Schaller, D. Bukala, S. Massberg, C. A. Sander, H. Braumuller, et al. (2009)
Blood
114, 1696-1706
|Abstract »|Full Text »|PDF »
Clock Gene Modulation by TNF-{alpha} Depends on Calcium and p38 MAP Kinase Signaling.
S. Petrzilka, C. Taraborrelli, G. Cavadini, A. Fontana, and T. Birchler (2009)
J Biol Rhythms
24, 283-294
|Abstract »|PDF »
Bcl3 Interacts Cooperatively with Peroxisome Proliferator-Activated Receptor Gamma (PPAR{gamma}) Coactivator 1{alpha} To Coactivate Nuclear Receptors Estrogen-Related Receptor {alpha} and PPAR{alpha}.
J. Yang, R. S. Williams, and D. P. Kelly (2009)
Mol. Cell. Biol.
29, 4091-4102
|Abstract »|Full Text »|PDF »
Active Uptake of Dendritic Cell-Derived Exovesicles by Epithelial Cells Induces the Release of Inflammatory Mediators through a TNF-{alpha}-Mediated Pathway.
C. Obregon, B. Rothen-Rutishauser, P. Gerber, P. Gehr, and L. P. Nicod (2009)
Am. J. Pathol.
175, 696-705
|Abstract »|Full Text »|PDF »
H. T. Hassoun, M. L. Lie, D. N. Grigoryev, M. Liu, R. M. Tuder, and H. Rabb (2009)
Am J Physiol Renal Physiol
297, F125-F137
|Abstract »|Full Text »|PDF »
WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor-{alpha} (TNF-{alpha})-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF-{alpha}-induced Cardiomyocyte Death.
K. Venkatachalam, B. Venkatesan, A. J. Valente, P. C. Melby, S. Nandish, J. E. B. Reusch, R. A. Clark, and B. Chandrasekar (2009)
J. Biol. Chem.
284, 14414-14427
|Abstract »|Full Text »|PDF »
Poxvirus MC160 Protein Utilizes Multiple Mechanisms To Inhibit NF-{kappa}B Activation Mediated via Components of the Tumor Necrosis Factor Receptor 1 Signal Transduction Pathway.
PRMT5, a Novel TRAIL Receptor-Binding Protein, Inhibits TRAIL-Induced Apoptosis via Nuclear Factor-{kappa}B Activation.
H. Tanaka, Y. Hoshikawa, T. Oh-hara, S. Koike, M. Naito, T. Noda, H. Arai, T. Tsuruo, and N. Fujita (2009)
Mol. Cancer Res.
7, 557-569
|Abstract »|Full Text »|PDF »
ROS and Innate Immunity.
C. KOHCHI, H. INAGAWA, T. NISHIZAWA, and G.-I. SOMA (2009)
Anticancer Res
29, 817-821
|Abstract »|Full Text »|PDF »
Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor {alpha}-Mediated Ceramide De novo Synthesis in Colon Cancer Cells.
F. Cianchi, L. Papucci, N. Schiavone, M. Lulli, L. Magnelli, M. C. Vinci, L. Messerini, C. Manera, E. Ronconi, P. Romagnani, et al. (2008)
Clin. Cancer Res.
14, 7691-7700
|Abstract »|Full Text »|PDF »
Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration.
T. C. Frank-Cannon, T. Tran, K. A. Ruhn, T. N. Martinez, J. Hong, M. Marvin, M. Hartley, I. Trevino, D. E. O'Brien, B. Casey, et al. (2008)
J. Neurosci.
28, 10825-10834
|Abstract »|Full Text »|PDF »
The Interaction between Human Papillomavirus Type 16 and FADD Is Mediated by a Novel E6 Binding Domain.
S. S. Tungteakkhun, M. Filippova, J. W. Neidigh, N. Fodor, and P. J. Duerksen-Hughes (2008)
J. Virol.
82, 9600-9614
|Abstract »|Full Text »|PDF »
Role of NF-{kappa}B and PI 3-kinase/Akt in TNF-{alpha}-induced cytotoxicity in microvascular endothelial cells.
Z. Zhou, P. Gengaro, W. Wang, X.-q. Wang, C. Li, S. Faubel, C. Rivard, and R. W. Schrier (2008)
Am J Physiol Renal Physiol
295, F932-F941
|Abstract »|Full Text »|PDF »
Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.
A. P. Komarov, O. W. Rokhlin, C.-A. Yu, and A. V. Gudkov (2008)
PNAS
105, 14453-14458
|Abstract »|Full Text »|PDF »
cAMP-dependent Protein Kinase A (PKA) Signaling Induces TNFR1 Exosome-like Vesicle Release via Anchoring of PKA Regulatory Subunit RII{beta} to BIG2.
A. Islam, H. Jones, T. Hiroi, J. Lam, J. Zhang, J. Moss, M. Vaughan, and S. J. Levine (2008)
J. Biol. Chem.
283, 25364-25371
|Abstract »|Full Text »|PDF »
c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor {alpha} (TNF{alpha})-induced NF-{kappa}B Activation.
E. Varfolomeev, T. Goncharov, A. V. Fedorova, J. N. Dynek, K. Zobel, K. Deshayes, W. J. Fairbrother, and D. Vucic (2008)
J. Biol. Chem.
283, 24295-24299
|Abstract »|Full Text »|PDF »
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
N.-J. Chen, I. I. C. Chio, W.-J. Lin, G. Duncan, H. Chau, D. Katz, H.-L. Huang, K. A. Pike, Z. Hao, Y.-W. Su, et al. (2008)
PNAS
105, 12429-12434
|Abstract »|Full Text »|PDF »
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier.
A. M. S. Hartz, B. Bauer, M. L. Block, J.-S. Hong, and D. S. Miller (2008)
FASEB J
22, 2723-2733
|Abstract »|Full Text »|PDF »
Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex.
A. Matsuzawa, P.-H. Tseng, S. Vallabhapurapu, J.-L. Luo, W. Zhang, H. Wang, D. A. A. Vignali, E. Gallagher, and M. Karin (2008)
Science
321, 663-668
|Abstract »|Full Text »|PDF »
Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape.
A. Sekulic, P. Haluska Jr, A. J. Miller, J. G. De Lamo, S. Ejadi, J. S. Pulido, D. R. Salomao, E. C. Thorland, R. G. Vile, D. L. Swanson, et al. (2008)
Mayo Clin. Proc.
83, 825-846
|Abstract »|Full Text »|PDF »
Abrogation of Anti-Inflammatory Transcription Factor LKLF in Neutrophil-Dominated Airways.
M. T. Saavedra, A. D. Patterson, J. West, S. H. Randell, D. W. Riches, K. C. Malcolm, C. D. Cool, J. A. Nick, and C. A. Dinarello (2008)
Am. J. Respir. Cell Mol. Biol.
38, 679-688
|Abstract »|Full Text »|PDF »
Uniocular Anterior Chamber Inoculation of a Tumor Necrosis Factor Alpha-Expressing Recombinant of Herpes Simplex Virus Type 1 Results in More Rapid Destruction and Increased Viral Replication in the Retina of the Uninoculated Eye.
M. A. Fields, M. Zheng, P. Wall, S. Oberg, and S. S. Atherton (2008)
J. Virol.
82, 5068-5078
|Abstract »|Full Text »|PDF »
Desflurane Preconditioning Inhibits Endothelial Nuclear Factor-{kappa}-B Activation by Targeting the Proximal End of Tumor Necrosis Factor-{alpha} Signaling.
Cystic Fibrosis Transmembrane Conductance Regulator Controls Lung Proteasomal Degradation and Nuclear Factor-{kappa}B Activity in Conditions of Oxidative Stress.
E. Boncoeur, T. Roque, E. Bonvin, V. Saint-Criq, M. Bonora, A. Clement, O. Tabary, A. Henrion-Caude, and J. Jacquot (2008)
Am. J. Pathol.
172, 1184-1194
|Abstract »|Full Text »|PDF »
Simvastatin antagonizes tumor necrosis factor-{alpha} inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.
M. Yamashita, F. Otsuka, T. Mukai, H. Otani, K. Inagaki, T. Miyoshi, J. Goto, M. Yamamura, and H. Makino (2008)
J. Endocrinol.
196, 601-613
|Abstract »|Full Text »|PDF »
Transglutaminase Type II Is Involved in the Pathogenesis of Endotoxic Shock.
L. Falasca, M. G. Farrace, A. Rinaldi, L. Tuosto, G. Melino, and M. Piacentini (2008)
J. Immunol.
180, 2616-2624
|Abstract »|Full Text »|PDF »
Aberrant activation of stress-response pathways leads to TNF-{alpha} oversecretion in Fanconi anemia.
D. Briot, G. Mace-Aime, F. Subra, and F. Rosselli (2008)
Blood
111, 1913-1923
|Abstract »|Full Text »|PDF »
Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-{alpha} Antagonist.
H. Shibata, Y. Yoshioka, A. Ohkawa, K. Minowa, Y. Mukai, Y. Abe, M. Taniai, T. Nomura, H. Kayamuro, H. Nabeshi, et al. (2008)
J. Biol. Chem.
283, 998-1007
|Abstract »|Full Text »|PDF »
Activation of Rho Kinase by TNF-{alpha} Is Required for JNK Activation in Human Pulmonary Microvascular Endothelial Cells.
P. Y. Mong, C. Petrulio, H. L. Kaufman, and Q. Wang (2008)
J. Immunol.
180, 550-558
|Abstract »|Full Text »|PDF »
FOXO3a Turns the Tumor Necrosis Factor Receptor Signaling Towards Apoptosis Through Reciprocal Regulation of c-Jun N-Terminal Kinase and NF-{kappa}B.
H.-Y. Lee, S.-W. Youn, J.-Y. Kim, K.-W. Park, C.-I. Hwang, W.-Y. Park, B.-H. Oh, Y.-B. Park, K. Walsh, J.-S. Seo, et al. (2008)
Arterioscler Thromb Vasc Biol
28, 112-120
|Abstract »|Full Text »|PDF »
Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing.
J. F. de Vries, P. A. von dem Borne, S. A.P. van Luxemburg-Heijs, M. H.M. Heemskerk, R. Willemze, J.H. F. Falkenburg, and R. M.Y. Barge (2007)
Haematologica
92, 1671-1678
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor-{alpha} Augments Matrix Metalloproteinase-9 Production in Skeletal Muscle Cells through the Activation of Transforming Growth Factor- -activated Kinase 1 (TAK1)-dependent Signaling Pathway.
A. K. Srivastava, X. Qin, N. Wedhas, M. Arnush, T. A. Linkhart, R. B. Chadwick, and A. Kumar (2007)
J. Biol. Chem.
282, 35113-35124
|Abstract »|Full Text »|PDF »
Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1.
P. La, Y. Yang, S. K. Karnik, A. C. Silva, R. W. Schnepp, S. K. Kim, and X. Hua (2007)
J. Biol. Chem.
282, 31332-31340
|Abstract »|Full Text »|PDF »
The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema.
R. Marhaba, M. Vitacolonna, D. Hildebrand, M. Baniyash, P. Freyschmidt-Paul, and M. Zoller (2007)
J. Immunol.
179, 5071-5081
|Abstract »|Full Text »|PDF »
Blockade of Tumor Necrosis Factor-induced Bid Cleavage by Caspase-resistant Rb.
X. Huang, A. Masselli, S. M. Frisch, I. C. Hunton, Y. Jiang, and J. Y. J. Wang (2007)
J. Biol. Chem.
282, 29401-29413
|Abstract »|Full Text »|PDF »
Smad7 Sensitizes Tumor Necrosis Factor Induced Apoptosis through the Inhibition of Antiapoptotic Gene Expression by Suppressing Activation of the Nuclear Factor-{kappa}B Pathway.
Tumor Necrosis Factor Receptor-1 Can Function through a G{alpha}q/11-beta-Arrestin-1 Signaling Complex.
Y. Kawamata, T. Imamura, J. L. Babendure, J.-C. Lu, T. Yoshizaki, and J. M. Olefsky (2007)
J. Biol. Chem.
282, 28549-28556
|Abstract »|Full Text »|PDF »
Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF {alpha} in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.
E. Kunisch, M. Gandesiri, R. Fuhrmann, A. Roth, R. Winter, and R. W Kinne (2007)
Ann Rheum Dis
66, 1043-1051
|Abstract »|Full Text »|PDF »
Lipid Rafts and Nonrafts Mediate Tumor Necrosis Factor Related Apoptosis-Inducing Ligand Induced Apoptotic and Nonapoptotic Signals in Non Small Cell Lung Carcinoma Cells.
J. H. Song, M. C.L. Tse, A. Bellail, S. Phuphanich, F. Khuri, N. M. Kneteman, and C. Hao (2007)
Cancer Res.
67, 6946-6955
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor Activates a Conserved Innate Antiviral Response to Hepatitis B Virus That Destabilizes Nucleocapsids and Reduces Nuclear Viral DNA.
Nuclear Corepressor Is Required for Inhibition of Phosphoenolpyruvate Carboxykinase Expression by Tumor Necrosis Factor-{alpha}.
J. Yan, Z. Gao, G. Yu, Q. He, J. Weng, and J. Ye (2007)
Mol. Endocrinol.
21, 1630-1641
|Abstract »|Full Text »|PDF »
Hepatic Tumor Necrosis Factor Signaling and Nuclear Factor-{kappa}B: Effects on Liver Homeostasis and Beyond.
A. Wullaert, G. van Loo, K. Heyninck, and R. Beyaert (2007)
Endocr. Rev.
28, 365-386
|Abstract »|Full Text »|PDF »
Chronic Tumor Necrosis Factor-{alpha} Treatment Causes Insulin Resistance via Insulin Receptor Substrate-1 Serine Phosphorylation and Suppressor of Cytokine Signaling-3 Induction in 3T3-L1 Adipocytes.
K. Ishizuka, I. Usui, Y. Kanatani, A. Bukhari, J. He, S. Fujisaka, Y. Yamazaki, H. Suzuki, K. Hiratani, M. Ishiki, et al. (2007)
Endocrinology
148, 2994-3003
|Abstract »|Full Text »|PDF »
A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis.
C. Stevens, Y. Lin, M. Sanchez, E. Amin, E. Copson, H. White, V. Durston, D. M. Eccles, and T. Hupp (2007)
J. Biol. Chem.
282, 13791-13803
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor Receptor 2-Mediated Tumor Suppression Is Nitric Oxide Dependent and Involves Angiostasis.
X. Zhao, M. Mohaupt, J. Jiang, S. Liu, B. Li, and Z. Qin (2007)
Cancer Res.
67, 4443-4450
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor Receptor 1/c-Jun-NH2-Kinase Signaling Promotes Human Neoplasia.
J. Y. Zhang, A. E. Adams, T. W. Ridky, S. Tao, and P. A. Khavari (2007)
Cancer Res.
67, 3827-3834
|Abstract »|Full Text »|PDF »
Polyamine-mediated Apoptosis of Alveolar Macrophages during Pneumocystis Pneumonia.
M. E. Lasbury, S. Merali, P. J. Durant, D. Tschang, C. A. Ray, and C.-H. Lee (2007)
J. Biol. Chem.
282, 11009-11020
|Abstract »|Full Text »|PDF »
The Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.
A. Islam, X. Shen, T. Hiroi, J. Moss, M. Vaughan, and S. J. Levine (2007)
J. Biol. Chem.
282, 9591-9599
|Abstract »|Full Text »|PDF »
Tumor necrosis factor {alpha} (TNF-{alpha}) receptor-II is required for TNF-{alpha}-induced leukocyte-endothelial interaction in vivo.
U. M. Chandrasekharan, M. Siemionow, M. Unsal, L. Yang, E. Poptic, J. Bohn, K. Ozer, Z. Zhou, P. H. Howe, M. Penn, et al. (2007)
Blood
109, 1938-1944
|Abstract »|Full Text »|PDF »
Cell-specific expression of X-linked inhibitor of apoptosis in the anterior pituitary of streptozotocin-induced diabetic rats.
A. I Arroba, A. M Lechuga-Sancho, L. M Frago, J. Argente, and J. A Chowen (2007)
J. Endocrinol.
192, 215-227
|Abstract »|Full Text »|PDF »
Ozonized Low Density Lipoprotein (ozLDL) Inhibits NF-{kappa}B and IRAK-1-Associated Signaling.
C. Cappello, B. Saugel, K. C. Huth, A. Zwergal, M. Krautkramer, C. Furman, M. Rouis, B. Wieser, H. W. Schneider, D. Neumeier, et al. (2007)
Arterioscler Thromb Vasc Biol
27, 226-232
|Abstract »|Full Text »|PDF »
Human Cytomegalovirus Blocks Tumor Necrosis Factor Alpha- and Interleukin-1{beta}-Mediated NF-{kappa}B Signaling.
C. Montag, J. Wagner, I. Gruska, and C. Hagemeier (2006)
J. Virol.
80, 11686-11698
|Abstract »|Full Text »|PDF »
Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis.
Disruption of {alpha}-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.
J. W. Triplett and F. M. Pavalko (2006)
Am J Physiol Cell Physiol
291, C909-C921
|Abstract »|Full Text »|PDF »
HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-{alpha} in cerebral vascular endothelial cells.
S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, C. W. Leffler, and H. Parfenova (2006)
Am J Physiol Cell Physiol
291, C897-C908
|Abstract »|Full Text »|PDF »
Role of FIP200 in cardiac and liver development and its regulation of TNF{alpha} and TSC-mTOR signaling pathways.
B. Gan, X. Peng, T. Nagy, A. Alcaraz, H. Gu, and J.-L. Guan (2006)
J. Cell Biol.
175, 121-133
|Abstract »|Full Text »|PDF »
Increased apoptosis of lactotrophs in streptozotocin-induced diabetic rats is followed by increased proliferation..
A. I Arroba, A. M Lechuga-Sancho, L. M Frago, J. Argente, and J. A Chowen (2006)
J. Endocrinol.
191, 55-63
|Abstract »|Full Text »|PDF »
Regulation of IL-1 and TNF Receptor Expression and Function by Endogenous Macrophage Migration Inhibitory Factor.
M.-L. Toh, D. Aeberli, D. Lacey, Y. Yang, L. L. Santos, M. Clarkson, L. Sharma, C. Clyne, and E. F. Morand (2006)
J. Immunol.
177, 4818-4825
|Abstract »|Full Text »|PDF »
JAB1 Determines the Response of Rheumatoid Arthritis Synovial Fibroblasts to Tumor Necrosis Factor-{alpha}.
J. Wang, C. Li, Y. Liu, W. Mei, S. Yu, C. Liu, L. Zhang, X. Cao, R. P. Kimberly, W. Grizzle, et al. (2006)
Am. J. Pathol.
169, 889-902
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor-{alpha} and Vascular Angiotensin II in Estrogen-Deficient Rats.
I. A. Arenas, S. J. Armstrong, Y. Xu, and S. T. Davidge (2006)
Hypertension
48, 497-503
|Abstract »|Full Text »|PDF »
Variation in Ligand Binding Specificities of a Novel Class of Poxvirus-encoded Tumor Necrosis Factor-binding Protein.
M. M. Rahman, J. W. Barrett, P. Brouckaert, and G. McFadden (2006)
J. Biol. Chem.
281, 22517-22526
|Abstract »|Full Text »|PDF »
Essential role of TAK1 in thymocyte development and activation.
H.-H. Liu, M. Xie, M. D. Schneider, and Z. J. Chen (2006)
PNAS
103, 11677-11682
|Abstract »|Full Text »|PDF »
C/EBPbeta Blocks p65 Phosphorylation and Thereby NF-{kappa}B-Mediated Transcription in TNF-Tolerant Cells.
A. Zwergal, M. Quirling, B. Saugel, K. C. Huth, C. Sydlik, V. Poli, D. Neumeier, H. W. L. Ziegler-Heitbrock, and K. Brand (2006)
J. Immunol.
177, 665-672
|Abstract »|Full Text »|PDF »
Peroxisome proliferator-activated receptor-{gamma} inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.
S. Y. Lee, E. J. Kang, G. Y. Hur, K. H. Jung, H. C. Jung, S. Y. Lee, J. H. Kim, C. Shin, K. H. In, K. H. Kang, et al. (2006)
Am J Physiol Lung Cell Mol Physiol
291, L84-L90
|Abstract »|Full Text »|PDF »
Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene.
J. E. Jennings-Gee, Y. Tsuji, E. C. Pietsch, E. Moran, J. S. Mymryk, F. M. Torti, and S. V. Torti (2006)
J. Biol. Chem.
281, 16428-16435
|Abstract »|Full Text »|PDF »
PanR1, a Dominant Negative Missense Allele of the Gene Encoding TNF-{alpha} (Tnf), Does Not Impair Lymphoid Development..
S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B. I. Dahiyat, P. Steed, and B. Beutler (2006)
J. Immunol.
176, 7525-7532
|Abstract »|Full Text »|PDF »
Adenoviral vectors encoding tumor necrosis factor-{alpha} and FasL induce apoptosis of normal and tumoral anterior pituitary cells..
M Candolfi, G Jaita, D Pisera, L Ferrari, C Barcia, C Liu, J Yu, G Liu, M G Castro, and A Seilicovich (2006)
J. Endocrinol.
189, 681-690
|Abstract »|Full Text »|PDF »
Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat.
T. Gorrill, M. Feliciano, R. Mukerjee, B. E. Sawaya, K. Khalili, and M. K. White (2006)
J. Gen. Virol.
87, 1557-1566
|Abstract »|Full Text »|PDF »
Attenuation of Mitogen- and Stress-Activated Protein Kinase-1-Driven Nuclear Factor-{kappa}B Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity..
W. Vanden Berghe, N. Dijsselbloem, L. Vermeulen, M. N. Ndlovu, E. Boone, and G. Haegeman (2006)
Cancer Res.
66, 4852-4862
|Abstract »|Full Text »|PDF »
Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-{kappa}B Activation and a Reciprocal Suppression of TGF-beta Signal Pathway.
Y. Ishida, T. Kondo, A. Kimura, K. Matsushima, and N. Mukaida (2006)
J. Immunol.
176, 5598-5606
|Abstract »|Full Text »|PDF »
Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1{alpha}-Mediated NF-{kappa}B Activation and Down-Regulation of TRAF2 Expression.
P. Hu, Z. Han, A. D. Couvillon, R. J. Kaufman, and J. H. Exton (2006)
Mol. Cell. Biol.
26, 3071-3084
|Abstract »|Full Text »|PDF »
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures.
R P Lisak, J A Benjamins, B Bealmear, B Yao, S Land, L Nedelkoska, and D Skundric (2006)
Multiple Sclerosis
12, 149-168
|Abstract »|PDF »
Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation.
Y. Xu, S. Huang, Z.-G. Liu, and J. Han (2006)
J. Biol. Chem.
281, 8788-8795
|Abstract »|Full Text »|PDF »
Extracellular TNFR1 Release Requires the Calcium-dependent Formation of a Nucleobindin 2-ARTS-1 Complex.
A. Islam, B. Adamik, F. I. Hawari, G. Ma, F. N. Rouhani, J. Zhang, and S. J. Levine (2006)
J. Biol. Chem.
281, 6860-6873
|Abstract »|Full Text »|PDF »
The MC160 Protein Expressed by the Dermatotropic Poxvirus Molluscum Contagiosum Virus Prevents Tumor Necrosis Factor Alpha-Induced NF-{kappa}B Activation via Inhibition of I Kappa Kinase Complex Formation.
TAK1 Is Recruited to the Tumor Necrosis Factor-{alpha} (TNF-{alpha}) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-{kappa}B Activation.
M. Blonska, P. B. Shambharkar, M. Kobayashi, D. Zhang, H. Sakurai, B. Su, and X. Lin (2005)
J. Biol. Chem.
280, 43056-43063
|Abstract »|Full Text »|PDF »
PAK4 Functions in Tumor Necrosis Factor (TNF) {alpha}-induced Survival Pathways by Facilitating TRADD Binding to the TNF Receptor.
Enhancement of Sensitivity to Tumor Necrosis Factor {alpha} in Non-Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib.
K. Ando, T. Ohmori, F. Inoue, T. Kadofuku, T. Hosaka, H. Ishida, T. Shirai, K. Okuda, T. Hirose, N. Horichi, et al. (2005)
Clin. Cancer Res.
11, 8872-8879
|Abstract »|Full Text »|PDF »
Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand.
E. Varfolomeev, H. Maecker, D. Sharp, D. Lawrence, M. Renz, D. Vucic, and A. Ashkenazi (2005)
J. Biol. Chem.
280, 40599-40608
|Abstract »|Full Text »|PDF »
Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD.
W. Matsuyama, H. Mitsuyama, M. Watanabe, K.-i. Oonakahara, I. Higashimoto, M. Osame, and K. Arimura (2005)
Chest
128, 3817-3827
|Abstract »|Full Text »|PDF »
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
J.-H. Shim, C. Xiao, A. E. Paschal, S. T. Bailey, P. Rao, M. S. Hayden, K.-Y. Lee, C. Bussey, M. Steckel, N. Tanaka, et al. (2005)
Genes & Dev.
19, 2668-2681
|Abstract »|Full Text »|PDF »
Distinct Role of Calmodulin and Calmodulin-dependent Protein Kinase-II in Lipopolysaccharide and Tumor Necrosis Factor-{alpha}-mediated Suppression of Apoptosis and Antiapoptotic c-IAP2 Gene Expression in Human Monocytic Cells.
S. Mishra, J. P. Mishra, K. Gee, D. C. McManus, E. C. LaCasse, and A. Kumar (2005)
J. Biol. Chem.
280, 37536-37546
|Abstract »|Full Text »|PDF »
Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death.
T. Noguchi, K. Takeda, A. Matsuzawa, K. Saegusa, H. Nakano, J. Gohda, J.-i. Inoue, and H. Ichijo (2005)
J. Biol. Chem.
280, 37033-37040
|Abstract »|Full Text »|PDF »
Mechanism for Removal of Tumor Necrosis Factor Receptor 1 from the Cell Surface by the Adenovirus RID{alpha}/{beta} Complex.
Inhibition of Tumor Necrosis Factor-{alpha}-Induced RANTES Secretion by Alkaline Protease in A549 Cells.
T. M. Krunkosky, K. Maruo, J. Potempa, C. L. Jarrett, and J. Travis (2005)
Am. J. Respir. Cell Mol. Biol.
33, 483-489
|Abstract »|Full Text »|PDF »
Tumor Necrosis Factor-{alpha} Triggers Mucus Production in Airway Epithelium through an I{kappa}B Kinase {beta}-dependent Mechanism.
J. M. Lora, D. M. Zhang, S. M. Liao, T. Burwell, A. M. King, P. A. Barker, L. Singh, M. Keaveney, J. Morgenstern, J. C. Gutierrez-Ramos, et al. (2005)
J. Biol. Chem.
280, 36510-36517
|Abstract »|Full Text »|PDF »
Activation of Caspase 8 in the Pituitaries of Streptozotocin-Induced Diabetic Rats: Implication in Increased Apoptosis of Lactotrophs.
A. I. Arroba, L. M. Frago, J. Argente, and J. A. Chowen (2005)
Endocrinology
146, 4417-4424
|Abstract »|Full Text »|PDF »
In Vivo Infusion of Interleukin-1{beta} and Chorionic Gonadotropin Induces Endometrial Changes that Mimic Early Pregnancy Events in the Baboon.
Z. Strakova, P. Mavrogianis, X. Meng, J. M. Hastings, K. S. Jackson, P. Cameo, A. Brudney, O. Knight, and A. T. Fazleabas (2005)
Endocrinology
146, 4097-4104
|Abstract »|Full Text »|PDF »
