Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 287 (5454): 873-880

Copyright © 2000 by the American Association for the Advancement of Science

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

Christopher J. Roberts, 1* Bryce Nelson, 2* Matthew J. Marton, 1 Roland Stoughton, 1 Michael R. Meyer, 1 Holly A. Bennett, 1 Yudong D. He, 1 Hongyue Dai, 1 Wynn L. Walker, 1 Timothy R. Hughes, 1 Mike Tyers, 3 Charles Boone, 2 † Stephen H. Friend 1dagger

Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response. Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. A two-dimensional hierarchical clustered matrix, covering 383 of the most highly regulated genes, was constructed from 46 diverse experimental conditions. Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. Analysis of the profiles specified by two different MAPKs--Fus3p and Kss1p--revealed functional overlap of the filamentous growth and mating responses. Global transcript analysis reflects biological responses associated with the activation and perturbation of signal transduction pathways.

1 Rosetta Inpharmatics, 12040 115th Avenue Northeast, Kirkland, WA 98034, USA.
2 Biology Department, Queen's University, Kingston, Ontario K7L 3N6, Canada.
3 Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Room 1080, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: boonec{at} and sfriend{at}

Antisense expression increases gene expression variability and locus interdependency.
Z. Xu, W. Wei, J. Gagneur, S. Clauder-Munster, M. Smolik, W. Huber, and L. M. Steinmetz (2014)
Mol Syst Biol 7, 468
   Abstract »    Full Text »    PDF »
Elucidating regulatory mechanisms downstream of a signaling pathway using informative experiments.
E. Szczurek, I. Gat-Viks, J. Tiuryn, and M. Vingron (2014)
Mol Syst Biol 5, 287
   Abstract »    Full Text »    PDF »
On the relation between promoter divergence and gene expression evolution.
I. Tirosh, A. Weinberger, D. Bezalel, M. Kaganovich, and N. Barkai (2014)
Mol Syst Biol 4, 159
   Abstract »    Full Text »    PDF »
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
S. Legewie, H. Herzel, H. V. Westerhoff, and N. Bluthgen (2014)
Mol Syst Biol 4, 190
   Abstract »    Full Text »    PDF »
Positive roles for negative regulators in the mating response of yeast.
J. R. Houser, E. Ford, M. J. Nagiec, B. Errede, and T. C. Elston (2014)
Mol Syst Biol 8, 586
   Abstract »    Full Text »    PDF »
Molecular mechanisms of system responses to novel stimuli are predictable from public data.
S. A. Danziger, A. V. Ratushny, J. J. Smith, R. A. Saleem, Y. Wan, C. E. Arens, A. M. Armstrong, K. Sitko, W.-M. Chen, J.-H. Chiang, et al. (2014)
Nucleic Acids Res. 42, 1442-1460
   Abstract »    Full Text »    PDF »
Topology and Control of the Cell-Cycle-Regulated Transcriptional Circuitry.
S. B. Haase and C. Wittenberg (2014)
Genetics 196, 65-90
   Abstract »    Full Text »    PDF »
PhosphoChain: a novel algorithm to predict kinase and phosphatase networks from high-throughput expression data.
W.-M. Chen, S. A. Danziger, J.-H. Chiang, and J. D. Aitchison (2013)
Bioinformatics 29, 2435-2444
   Abstract »    Full Text »    PDF »
Regulation of Yeast G Protein Signaling by the Kinases That Activate the AMPK Homolog Snf1.
S. T. Clement, G. Dixit, and H. G. Dohlman (2013)
Science Signaling 6, ra78
   Abstract »    Full Text »    PDF »
Mapping Yeast Transcriptional Networks.
T. R. Hughes and C. G. de Boer (2013)
Genetics 195, 9-36
   Abstract »    Full Text »    PDF »
A New System for Comparative Functional Genomics of Saccharomyces Yeasts.
A. A. Caudy, Y. Guan, Y. Jia, C. Hansen, C. DeSevo, A. P. Hayes, J. Agee, J. R. Alvarez-Dominguez, H. Arellano, D. Barrett, et al. (2013)
Genetics 195, 275-287
   Abstract »    Full Text »    PDF »
Unisexual Reproduction Enhances Fungal Competitiveness by Promoting Habitat Exploration via Hyphal Growth and Sporulation.
S. S. Phadke, M. Feretzaki, and J. Heitman (2013)
Eukaryot. Cell 12, 1155-1159
   Abstract »    Full Text »    PDF »
Pheromone-Induced Morphogenesis Improves Osmoadaptation Capacity by Activating the HOG MAPK Pathway.
R. Baltanas, A. Bush, A. Couto, L. Durrieu, S. Hohmann, and A. Colman-Lerner (2013)
Science Signaling 6, ra26
   Abstract »    Full Text »    PDF »
Genetic Networks Inducing Invasive Growth in Saccharomyces cerevisiae Identified Through Systematic Genome-Wide Overexpression.
C. A. Shively, M. J. Eckwahl, C. J. Dobry, D. Mellacheruvu, A. Nesvizhskii, and A. Kumar (2013)
Genetics 193, 1297-1310
   Abstract »    Full Text »    PDF »
Mate and fuse: how yeast cells do it.
L. Merlini, O. Dudin, and S. G. Martin (2013)
Open Bio 3, 130008
   Abstract »    Full Text »    PDF »
Phosphoproteomic Analysis of Protein Kinase C Signaling in Saccharomyces cerevisiae Reveals Slt2 Mitogen-activated Protein Kinase (MAPK)-dependent Phosphorylation of Eisosome Core Components.
V. Mascaraque, M. L. Hernaez, M. Jimenez-Sanchez, R. Hansen, C. Gil, H. Martin, V. J. Cid, and M. Molina (2013)
Mol. Cell. Proteomics 12, 557-574
   Abstract »    Full Text »    PDF »
Activation of an Essential Calcium Signaling Pathway in Saccharomyces cerevisiae by Kch1 and Kch2, Putative Low-Affinity Potassium Transporters.
C. P. Stefan, N. Zhang, T. Sokabe, A. Rivetta, C. L. Slayman, C. Montell, and K. W. Cunningham (2013)
Eukaryot. Cell 12, 204-214
   Abstract »    Full Text »    PDF »
The Filamentous Growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 Transcriptional Repressors in Saccharomyces cerevisiae.
S. Karunanithi and P. J. Cullen (2012)
Genetics 192, 869-887
   Abstract »    Full Text »    PDF »
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.
N. Hao, N. Yildirim, M. J. Nagiec, S. C. Parnell, B. Errede, H. G. Dohlman, and T. C. Elston (2012)
Mol. Biol. Cell 23, 3899-3910
   Abstract »    Full Text »    PDF »
Functional specialisation of yeast Rho1 GTP exchange factors.
S. A. Krause, M. J. Cundell, P. P. Poon, J. McGhie, G. C. Johnston, C. Price, and J. V. Gray (2012)
J. Cell Sci. 125, 2721-2731
   Abstract »    Full Text »    PDF »
Vacuolar H+-ATPase Works in Parallel with the HOG Pathway To Adapt Saccharomyces cerevisiae Cells to Osmotic Stress.
S. C. Li, T. T. Diakov, J. M. Rizzo, and P. M. Kane (2012)
Eukaryot. Cell 11, 282-291
   Abstract »    Full Text »    PDF »
Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation.
D. E. Egecioglu, T. R. Kawashima, and G. F. Chanfreau (2012)
Nucleic Acids Res. 40, 1787-1796
   Abstract »    Full Text »    PDF »
The Regulation of Filamentous Growth in Yeast.
P. J. Cullen and G. F. Sprague Jr. (2012)
Genetics 190, 23-49
   Abstract »    Full Text »    PDF »
Natural Selection on Gene Order in the Genome Reorganization Process After Whole-Genome Duplication of Yeast.
R. P. Sugino and H. Innan (2012)
Mol. Biol. Evol. 29, 71-79
   Abstract »    Full Text »    PDF »
Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.
T. M. Thomson, K. R. Benjamin, A. Bush, T. Love, D. Pincus, O. Resnekov, R. C. Yu, A. Gordon, A. Colman-Lerner, D. Endy, et al. (2011)
PNAS 108, 20265-20270
   Abstract »    Full Text »    PDF »
Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway.
D. E. Levin (2011)
Genetics 189, 1145-1175
   Abstract »    Full Text »    PDF »
Nutrients and the Pkh1/2 and Pkc1 Protein Kinases Control mRNA Decay and P-body Assembly in Yeast.
G. Luo, M. Costanzo, C. Boone, and R. C. Dickson (2011)
J. Biol. Chem. 286, 8759-8770
   Abstract »    Full Text »    PDF »
Evolutionary Reshaping of Fungal Mating Pathway Scaffold Proteins.
P. Cote, T. Sulea, D. Dignard, C. Wu, and M. Whiteway (2011)
mBio 2, e00230-10
   Abstract »    Full Text »    PDF »
Finding undetected protein associations in cell signaling by belief propagation.
M. Bailly-Bechet, C. Borgs, A. Braunstein, J. Chayes, A. Dagkessamanskaia, J.- M. Francois, and R. Zecchina (2011)
PNAS 108, 882-887
   Abstract »    Full Text »    PDF »
Identification of a Cell Death Pathway in Candida albicans during the Response to Pheromone.
K. Alby, D. Schaefer, R. K. Sherwood, S. K. Jones Jr., and R. J. Bennett (2010)
Eukaryot. Cell 9, 1690-1701
   Abstract »    Full Text »    PDF »
Dynamic Localization of Fus3 Mitogen-Activated Protein Kinase Is Necessary To Evoke Appropriate Responses and Avoid Cytotoxic Effects.
R. E. Chen, J. C. Patterson, L. S. Goupil, and J. Thorner (2010)
Mol. Cell. Biol. 30, 4293-4307
   Abstract »    Full Text »    PDF »
Bap170, a Subunit of the Drosophila PBAP Chromatin Remodeling Complex, Negatively Regulates the EGFR Signaling.
R. Rendina, A. Strangi, B. Avallone, and E. Giordano (2010)
Genetics 186, 167-181
   Abstract »    Full Text »    PDF »
Spatial cycles in G-protein crowd control.
N. Vartak and P. Bastiaens (2010)
EMBO J. 29, 2689-2699
   Abstract »    Full Text »    PDF »
MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures.
M. Vazquez, R. Nogales-Cadenas, J. Arroyo, P. Botias, R. Garcia, J. M. Carazo, F. Tirado, A. Pascual-Montano, and P. Carmona-Saez (2010)
Nucleic Acids Res. 38, W228-W232
   Abstract »    Full Text »    PDF »
Ste12 and Ste12-Like Proteins, Fungal Transcription Factors Regulating Development and Pathogenicity.
J. Wong Sak Hoi and B. Dumas (2010)
Eukaryot. Cell 9, 480-485
   Abstract »    Full Text »    PDF »
Mechanism of Mpk1 Mitogen-Activated Protein Kinase Binding to the Swi4 Transcription Factor and Its Regulation by a Novel Caffeine-Induced Phosphorylation.
A. W. Truman, K.-Y. Kim, and D. E. Levin (2009)
Mol. Cell. Biol. 29, 6449-6461
   Abstract »    Full Text »    PDF »
Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome.
F. Frederiks, G. J. J. E. Heynen, S. J. van Deventer, H. Janssen, and F. van Leeuwen (2009)
Nucleic Acids Res. 37, 7047-7058
   Abstract »    Full Text »    PDF »
The tRNA Modification Complex Elongator Regulates the Cdc42-Dependent Mitogen-Activated Protein Kinase Pathway That Controls Filamentous Growth in Yeast.
U. Abdullah and P. J. Cullen (2009)
Eukaryot. Cell 8, 1362-1372
   Abstract »    Full Text »    PDF »
Distinct Roles for Key Karyogamy Proteins during Yeast Nuclear Fusion.
P. Melloy, S. Shen, E. White, and M. D. Rose (2009)
Mol. Biol. Cell 20, 3773-3782
   Abstract »    Full Text »    PDF »
Developmentally regulated MAPK pathways modulate heterochromatin in Saccharomyces cerevisiae.
Y. Mazor and M. Kupiec (2009)
Nucleic Acids Res. 37, 4839-4849
   Abstract »    Full Text »    PDF »
Role of the Cell Wall Integrity and Filamentous Growth Mitogen-Activated Protein Kinase Pathways in Cell Wall Remodeling during Filamentous Growth.
B. Birkaya, A. Maddi, J. Joshi, S. J. Free, and P. J. Cullen (2009)
Eukaryot. Cell 8, 1118-1133
   Abstract »    Full Text »    PDF »
Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks.
S.-s. C. Huang and E. Fraenkel (2009)
Science Signaling 2, ra40
   Abstract »    Full Text »    PDF »
The Signaling Mucins Msb2 and Hkr1 Differentially Regulate the Filamentation Mitogen-activated Protein Kinase Pathway and Contribute to a Multimodal Response.
A. Pitoniak, B. Birkaya, H. M. Dionne, N. Vadaie, and P. J. Cullen (2009)
Mol. Biol. Cell 20, 3101-3114
   Abstract »    Full Text »    PDF »
The Class V Myosin Myo2p Is Required for Fus2p Transport and Actin Polarization during the Yeast Mating Response.
J. M. Sheltzer and M. D. Rose (2009)
Mol. Biol. Cell 20, 2909-2919
   Abstract »    Full Text »    PDF »
Prm3p Is a Pheromone-induced Peripheral Nuclear Envelope Protein Required for Yeast Nuclear Fusion.
S. Shen, C. E. Tobery, and M. D. Rose (2009)
Mol. Biol. Cell 20, 2438-2450
   Abstract »    Full Text »    PDF »
The High Osmotic Response and Cell Wall Integrity Pathways Cooperate to Regulate Transcriptional Responses to Zymolyase-induced Cell Wall Stress in Saccharomyces cerevisiae.
R. Garcia, J. M. Rodriguez-Pena, C. Bermejo, C. Nombela, and J. Arroyo (2009)
J. Biol. Chem. 284, 10901-10911
   Abstract »    Full Text »    PDF »
The cost of gene expression underlies a fitness trade-off in yeast.
G. I. Lang, A. W. Murray, and D. Botstein (2009)
PNAS 106, 5755-5760
   Abstract »    Full Text »    PDF »
Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform.
R. J. Taylor, D. Falconnet, A. Niemisto, S. A. Ramsey, S. Prinz, I. Shmulevich, T. Galitski, and C. L. Hansen (2009)
PNAS 106, 3758-3763
   Abstract »    Full Text »    PDF »
Antagonistic regulation of Fus2p nuclear localization by pheromone signaling and the cell cycle.
C. A. Ydenberg and M. D. Rose (2009)
J. Cell Biol. 184, 409-422
   Abstract »    Full Text »    PDF »
The Synthetic Genetic Network around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Saccharomyces cerevisiae.
S. A. Krause, H. Xu, and J. V. Gray (2008)
Eukaryot. Cell 7, 1880-1887
   Abstract »    Full Text »    PDF »
Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast.
N. Vadaie, H. Dionne, D. S. Akajagbor, S. R. Nickerson, D. J. Krysan, and P. J. Cullen (2008)
J. Cell Biol. 181, 1073-1081
   Abstract »    Full Text »    PDF »
Dynamic localization of yeast Fus2p to an expanding ring at the cell fusion junction during mating.
J. M. Paterson, C. A. Ydenberg, and M. D. Rose (2008)
J. Cell Biol. 181, 697-709
   Abstract »    Full Text »    PDF »
Stress resistance and signal fidelity independent of nuclear MAPK function.
P. J. Westfall, J. C. Patterson, R. E. Chen, and J. Thorner (2008)
PNAS 105, 12212-12217
   Abstract »    Full Text »    PDF »
Yeast Mpk1 Mitogen-Activated Protein Kinase Activates Transcription through Swi4/Swi6 by a Noncatalytic Mechanism That Requires Upstream Signal.
K.-Y. Kim, A. W. Truman, and D. E. Levin (2008)
Mol. Cell. Biol. 28, 2579-2589
   Abstract »    Full Text »    PDF »
The Same Receptor, G Protein, and Mitogen-activated Protein Kinase Pathway Activate Different Downstream Regulators in the Alternative White and Opaque Pheromone Responses of Candida albicans.
S. Yi, N. Sahni, K. J. Daniels, C. Pujol, T. Srikantha, and D. R. Soll (2008)
Mol. Biol. Cell 19, 957-970
   Abstract »    Full Text »    PDF »
Distinct Roles for Two G{alpha}-G{beta} Interfaces in Cell Polarity Control by a Yeast Heterotrimeric G Protein.
S. C. Strickfaden and P. M. Pryciak (2008)
Mol. Biol. Cell 19, 181-197
   Abstract »    Full Text »    PDF »
A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies.
L. Omberg, G. H. Golub, and O. Alter (2007)
PNAS 104, 18371-18376
   Abstract »    Full Text »    PDF »
Identification and Characterization of Vnx1p, a Novel Type of Vacuolar Monovalent Cation/H+ Antiporter of Saccharomyces cerevisiae.
O. Cagnac, M. Leterrier, M. Yeager, and E. Blumwald (2007)
J. Biol. Chem. 282, 24284-24293
   Abstract »    Full Text »    PDF »
YGR198w (YPP1) targets A30P {alpha}-synuclein to the vacuole for degradation.
T. R. Flower, C. Clark-Dixon, C. Metoyer, H. Yang, R. Shi, Z. Zhang, and S. N. Witt (2007)
J. Cell Biol. 177, 1091-1104
   Abstract »    Full Text »    PDF »
Quantitative Analysis of Human Immunodeficiency Virus Type 1-Infected CD4+ Cell Proteome: Dysregulated Cell Cycle Progression and Nuclear Transport Coincide with Robust Virus Production.
E. Y. Chan, W.-J. Qian, D. L. Diamond, T. Liu, M. A. Gritsenko, M. E. Monroe, D. G. Camp II, R. D. Smith, and M. G. Katze (2007)
J. Virol. 81, 7571-7583
   Abstract »    Full Text »    PDF »
Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks.
W. K. Lim, K. Wang, C. Lefebvre, and A. Califano (2007)
Bioinformatics 23, i282-i288
   Abstract »    Full Text »    PDF »
Barrier Activity in Candida albicans Mediates Pheromone Degradation and Promotes Mating.
D. Schaefer, P. Cote, M. Whiteway, and R. J. Bennett (2007)
Eukaryot. Cell 6, 907-918
   Abstract »    Full Text »    PDF »
An adaptation of the LMS method to determine expression variations in profiling data.
P. Chuchana, D. Marchand, M. Nugoli, C. Rodriguez, N. Molinari, and J. A. Garcia-Sanz (2007)
Nucleic Acids Res. 35, e71
   Abstract »    Full Text »    PDF »
Central Roles of Small GTPases in the Development of Cell Polarity in Yeast and Beyond.
H.-O. Park and E. Bi (2007)
Microbiol. Mol. Biol. Rev. 71, 48-96
   Abstract »    Full Text »    PDF »
Identification and Characterization of MFA1, the Gene Encoding Candida albicans a-Factor Pheromone.
D. Dignard, A. L. El-Naggar, M. E. Logue, G. Butler, and M. Whiteway (2007)
Eukaryot. Cell 6, 487-494
   Abstract »    Full Text »    PDF »
Role of Transcription Factor Kar4 in Regulating Downstream Events in the Saccharomyces cerevisiae Pheromone Response Pathway.
R. Lahav, A. Gammie, S. Tavazoie, and M. D. Rose (2007)
Mol. Cell. Biol. 27, 818-829
   Abstract »    Full Text »    PDF »
Signaling Alkaline pH Stress in the Yeast Saccharomyces cerevisiae through the Wsc1 Cell Surface Sensor and the Slt2 MAPK Pathway.
R. Serrano, H. Martin, A. Casamayor, and J. Arino (2006)
J. Biol. Chem. 281, 39785-39795
   Abstract »    Full Text »    PDF »
Pheromone-Induced Degradation of Ste12 Contributes to Signal Attenuation and the Specificity of Developmental Fate.
R. K. Esch, Y. Wang, and B. Errede (2006)
Eukaryot. Cell 5, 2147-2160
   Abstract »    Full Text »    PDF »
The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity.
X. Varelas, D. Stuart, M. J. Ellison, and C. Ptak (2006)
Genetics 174, 1825-1839
   Abstract »    Full Text »    PDF »
Role of the Transcription Activator Ste12p as a Repressor of PRY3 Expression.
K. S. Bickel and D. R. Morris (2006)
Mol. Cell. Biol. 26, 7901-7912
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae a-Factor Mutants Reveal Residues Critical for Processing, Activity, and Export.
G. Huyer, A. Kistler, F. J. Nouvet, C. M. George, M. L. Boyle, and S. Michaelis (2006)
Eukaryot. Cell 5, 1560-1570
   Abstract »    Full Text »    PDF »
Yeast homolog of a cancer-testis antigen defines a new transcription complex.
E. Kisseleva-Romanova, R. Lopreiato, A. Baudin-Baillieu, J.-C. Rousselle, L. Ilan, K. Hofmann, A. Namane, C. Mann, and D. Libri (2006)
EMBO J. 25, 3576-3585
   Abstract »    Full Text »    PDF »
Identifying transcription factor functions and targets by phenotypic activation.
G. Chua, Q. D. Morris, R. Sopko, M. D. Robinson, O. Ryan, E. T. Chan, B. J. Frey, B. J. Andrews, C. Boone, and T. R. Hughes (2006)
PNAS 103, 12045-12050
   Abstract »    Full Text »    PDF »
Analysis of Mitogen-Activated Protein Kinase Signaling Specificity in Response to Hyperosmotic Stress: Use of an Analog-Sensitive HOG1 Allele.
P. J. Westfall and J. Thorner (2006)
Eukaryot. Cell 5, 1215-1228
   Abstract »    Full Text »    PDF »
A three-hybrid screen identifies mRNAs controlled by a regulatory protein.
D. Seay, B. Hook, K. Evans, and M. Wickens (2006)
RNA 12, 1594-1600
   Abstract »    Full Text »    PDF »
Extensive low-affinity transcriptional interactions in the yeast genome.
A. Tanay (2006)
Genome Res. 16, 962-972
   Abstract »    Full Text »    PDF »
Activated signal transduction kinases frequently occupy target genes..
D. K. Pokholok, J. Zeitlinger, N. M. Hannett, D. B. Reynolds, and R. A. Young (2006)
Science 313, 533-536
   Abstract »    Full Text »    PDF »
Regulation of Mating and Filamentation Genes by Two Distinct Ste12 Complexes in Saccharomyces cerevisiae.
S. Chou, S. Lane, and H. Liu (2006)
Mol. Cell. Biol. 26, 4794-4805
   Abstract »    Full Text »    PDF »
Cell Wall Assembly in Saccharomyces cerevisiae.
G. Lesage and H. Bussey (2006)
Microbiol. Mol. Biol. Rev. 70, 317-343
   Abstract »    Full Text »    PDF »
Deciphering the Roles of the Histone H2B N-Terminal Domain in Genome-Wide Transcription.
M. A. Parra, D. Kerr, D. Fahy, D. J. Pouchnik, and J. J. Wyrick (2006)
Mol. Cell. Biol. 26, 3842-3852
   Abstract »    Full Text »    PDF »
Rosetta error model for gene expression analysis.
L. Weng, H. Dai, Y. Zhan, Y. He, S. B. Stepaniants, and D. E. Bassett (2006)
Bioinformatics 22, 1111-1121
   Abstract »    Full Text »    PDF »
Pheromone-regulated Sumoylation of Transcription Factors That Mediate the Invasive to Mating Developmental Switch in Yeast.
Y. Wang and H. G. Dohlman (2006)
J. Biol. Chem. 281, 1964-1969
   Abstract »    Full Text »    PDF »
Reconstructing the pathways of a cellular system from genome-scale signals by using matrix and tensor computations.
O. Alter and G. H. Golub (2005)
PNAS 102, 17559-17564
   Abstract »    Full Text »    PDF »
Changing perspectives in yeast research nearly a decade after the genome sequence.
K. Dolinski and D. Botstein (2005)
Genome Res. 15, 1611-1619
   Abstract »    Full Text »    PDF »
Identifying the conserved network of cis-regulatory sites of a eukaryotic genome.
T. Wang and G. D. Stormo (2005)
PNAS 102, 17400-17405
   Abstract »    Full Text »    PDF »
Androgen Control of Gene Expression in the Mouse Meibomian Gland.
F. Schirra, T. Suzuki, S. M. Richards, R. V. Jensen, M. Liu, M. J. Lombardi, P. Rowley, N. S. Treister, and D. A. Sullivan (2005)
Invest. Ophthalmol. Vis. Sci. 46, 3666-3675
   Abstract »    Full Text »    PDF »
A protocol for building and evaluating predictors of disease state based on microarray data.
L. F. A. Wessels, M. J. T. Reinders, A. A. M. Hart, C. J. Veenman, H. Dai, Y. D. He, and L. J. v. Veer (2005)
Bioinformatics 21, 3755-3762
   Abstract »    Full Text »    PDF »
Exploring Lactobacillus plantarum Genome Diversity by Using Microarrays.
D. Molenaar, F. Bringel, F. H. Schuren, W. M. de Vos, R. J. Siezen, and M. Kleerebezem (2005)
J. Bacteriol. 187, 6119-6127
   Abstract »    Full Text »    PDF »
A network of transcriptionally coordinated functional modules in Saccharomyces cerevisiae.
A. A. Petti and G. M. Church (2005)
Genome Res. 15, 1298-1306
   Abstract »    Full Text »    PDF »
Polarized Morphogenesis Regulator Spa2 Is Required for the Function of Putative Stretch-Activated Ca2+-Permeable Channel Component Mid1 in Saccharomyces cerevisiae.
S. Noma, K. Iida, and H. Iida (2005)
Eukaryot. Cell 4, 1353-1363
   Abstract »    Full Text »    PDF »
In search of candidate genes critically expressed in the human endometrium during the window of implantation.
S. Mirkin, M. Arslan, D. Churikov, A. Corica, J.I. Diaz, S. Williams, S. Bocca, and S. Oehninger (2005)
Hum. Reprod. 20, 2104-2117
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882