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Science 296 (5570): 1132-1136

Copyright © 2002 by the American Association for the Advancement of Science

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G0 Cells

Hidesato Ogawa,* Kei-ichiro Ishiguro,* Stefan Gaubatz,dagger David M. Livingston, Yoshihiro Nakataniddagger

E2F-6 contributes to gene silencing in a manner independent of retinoblastoma protein family members. To better elucidate the molecular mechanism of repression by E2F-6, we have purified the factor from cultured cells. E2F-6 is found in a multimeric protein complex that contains Mga and Max, and thus the complex can bind not only to the E2F-binding site but also to Myc- and Brachyury-binding sites. Moreover, the complex contains chromatin modifiers such as a novel histone methyltransferase that modifies lysine 9 of histone H3, HP1gamma , and Polycomb group (PcG) proteins. The E2F-6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells. These data suggest that these chromatin modifiers contribute to silencing of E2F- and Myc-responsive genes in quiescent cells.

Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
*   These authors contributed equally to this work.

dagger    Present address: Institute for Molecular Biology and Tumor Research, Philipps-University Marburg, D-35032 Marburg, Germany.

ddagger    To whom correspondence should be addressed. E-mail: yoshihiro_nakatani{at}

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E. Balciunaite, A. Spektor, N. H. Lents, H. Cam, H. te Riele, A. Scime, M. A. Rudnicki, R. Young, and B. D. Dynlacht (2005)
Mol. Cell. Biol. 25, 8166-8178
   Abstract »    Full Text »    PDF »
Rybp/DEDAF Is Required for Early Postimplantation and for Central Nervous System Development.
M. K. Pirity, J. Locker, and N. Schreiber-Agus (2005)
Mol. Cell. Biol. 25, 7193-7202
   Abstract »    Full Text »    PDF »
Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.
P.-O. Esteve, D. Patnaik, H. G. Chin, J. Benner, M. A. Teitell, and S. Pradhan (2005)
Nucleic Acids Res. 33, 3211-3223
   Abstract »    Full Text »    PDF »
Interaction of tSNARE Syntaxin 18 with the Papillomavirus Minor Capsid Protein Mediates Infection.
I. Bossis, R. B. S. Roden, R. Gambhira, R. Yang, M. Tagaya, P. M. Howley, and P. I. Meneses (2005)
J. Virol. 79, 6723-6731
   Abstract »    Full Text »    PDF »
In Vivo HP1 Targeting Causes Large-Scale Chromatin Condensation and Enhanced Histone Lysine Methylation.
P. J. Verschure, I. van der Kraan, W. de Leeuw, J. van der Vlag, A. E. Carpenter, A. S. Belmont, and R. van Driel (2005)
Mol. Cell. Biol. 25, 4552-4564
   Abstract »    Full Text »    PDF »
Differential Subnuclear Localization and Replication Timing of Histone H3 Lysine 9 Methylation States.
R. Wu, A. V. Terry, P. B. Singh, and D. M. Gilbert (2005)
Mol. Biol. Cell 16, 2872-2881
   Abstract »    Full Text »    PDF »
Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation.
B. Maiti, J. Li, A. de Bruin, F. Gordon, C. Timmers, R. Opavsky, K. Patil, J. Tuttle, W. Cleghorn, and G. Leone (2005)
J. Biol. Chem. 280, 18211-18220
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Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene.
K. A. Edgar, M. Belvin, A. L. Parks, K. Whittaker, M. B. Mahoney, M. Nicoll, C. C. Park, C. G. Winter, F. Chen, K. Lickteig, et al. (2005)
Genetics 170, 161-171
   Abstract »    Full Text »    PDF »
Disruption of the gene Euchromatin Histone Methyl Transferase1 (Eu-HMTase1) is associated with the 9q34 subtelomeric deletion syndrome.
T Kleefstra, M Smidt, M J G Banning, A R Oudakker, H Van Esch, A P M de Brouwer, W Nillesen, E A Sistermans, B C J Hamel, D de Bruijn, et al. (2005)
J. Med. Genet. 42, 299-306
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Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
M. Tachibana, J. Ueda, M. Fukuda, N. Takeda, T. Ohta, H. Iwanari, T. Sakihama, T. Kodama, T. Hamakubo, and Y. Shinkai (2005)
Genes & Dev. 19, 815-826
   Abstract »    Full Text »    PDF »

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