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Science 296 (5571): 1319-1321

Copyright © 2002 by the American Association for the Advancement of Science

Induction and Suppression of RNA Silencing by an Animal Virus

Hongwei Li, Wan Xiang Li, Shou Wei Ding*

RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.

Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA.
*   To whom correspondence should be addressed. E-mail: shou-wei.ding{at}

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La Crosse Virus Nonstructural Protein NSs Counteracts the Effects of Short Interfering RNA.
S. S. Soldan, M. L. Plassmeyer, M. K. Matukonis, and F. Gonzalez-Scarano (2005)
J. Virol. 79, 234-244
   Abstract »    Full Text »    PDF »
Nodamura Virus RNA Replication in Saccharomyces cerevisiae: Heterologous Gene Expression Allows Replication-Dependent Colony Formation.
B. D. Price, L. D. Eckerle, L. A. Ball, and K. L. Johnson (2005)
J. Virol. 79, 495-502
   Abstract »    Full Text »    PDF »
Antiviral Effects of Human Immunodeficiency Virus Type 1-Specific Small Interfering RNAs against Targets Conserved in Select Neurotropic Viral Strains.
R. S. Dave and R. J. Pomerantz (2004)
J. Virol. 78, 13687-13696
   Abstract »    Full Text »    PDF »
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity.
J. S. Parker, S. M. Roe, and D. Barford (2004)
EMBO J. 23, 4727-4737
   Abstract »    Full Text »    PDF »
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae.
K. M. Keene, B. D. Foy, I. Sanchez-Vargas, B. J. Beaty, C. D. Blair, and K. E. Olson (2004)
PNAS 101, 17240-17245
   Abstract »    Full Text »    PDF »
Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis.
S. Lu and B. R. Cullen (2004)
J. Virol. 78, 12868-12876
   Abstract »    Full Text »    PDF »
Three distinct suppressors of RNA silencing encoded by a 20-kb viral RNA genome.
R. Lu, A. Folimonov, M. Shintaku, W.-X. Li, B. W. Falk, W. O. Dawson, and S.-W. Ding (2004)
PNAS 101, 15742-15747
   Abstract »    Full Text »    PDF »

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