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Science 296 (5571): 1323-1326

Copyright © 2002 by the American Association for the Advancement of Science

Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

Hisashi Arase,1 Edward S. Mocarski,2 Ann E. Campbell,3 Ann B. Hill,4 Lewis L. Lanier1*

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

1 Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
2 Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
3 Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.
4 Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA.
*   To whom correspondence should be addressed. E-mail: lanier{at}

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K. Iizuka, A. A. Scalzo, H. Xian, and W. M. Yokoyama (2008)
J. Immunol. 180, 3260-3267
   Abstract »    Full Text »    PDF »
Direct Action of Type I IFN on NK Cells Is Required for Their Activation in Response to Vaccinia Viral Infection In Vivo.
J. Martinez, X. Huang, and Y. Yang (2008)
J. Immunol. 180, 1592-1597
   Abstract »    Full Text »    PDF »
An Essential Role of Sialylated O-Linked Sugar Chains in the Recognition of Mouse CD99 by Paired Ig-Like Type 2 Receptor (PILR).
J. Wang, I. Shiratori, T. Satoh, L. L. Lanier, and H. Arase (2008)
J. Immunol. 180, 1686-1693
   Abstract »    Full Text »    PDF »
TLR-dependent cross talk between human Kupffer cells and NK cells.
Z. Tu, A. Bozorgzadeh, R. H. Pierce, J. Kurtis, I. N. Crispe, and M. S. Orloff (2008)
J. Exp. Med. 205, 233-244
   Abstract »    Full Text »    PDF »
Human Cytomegalovirus Regulates Surface Expression of the Viral Protein UL18 by Means of Two Motifs Present in the Cytoplasmic Tail.
M. Maffei, F. Ghiotto, M. Occhino, M. Bono, A. De Santanna, L. Battini, G. L. Gusella, F. Fais, S. Bruno, and E. Ciccone (2008)
J. Immunol. 180, 969-979
   Abstract »    Full Text »    PDF »

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