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Science 296 (5573): 1634-1635

Copyright © 2002 by the American Association for the Advancement of Science

TNF-R1 Signaling: A Beautiful Pathway

Guoqing Chen, David V. Goeddel*

Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor-1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling complex at the cell membrane. Over the past decade, many of the components and mechanisms of these signaling pathways have been elucidated. We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process.

Tularik Inc., Two Corporate Drive, South San Francisco, CA 94080, USA.
*   To whom correspondence should be addressed. E-mail: goeddel{at}tularik.com

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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B. Gan, X. Peng, T. Nagy, A. Alcaraz, H. Gu, and J.-L. Guan (2006)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Wang, C. Li, Y. Liu, W. Mei, S. Yu, C. Liu, L. Zhang, X. Cao, R. P. Kimberly, W. Grizzle, et al. (2006)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Gen. Virol. 87, 1557-1566
   Abstract »    Full Text »    PDF »
Attenuation of Mitogen- and Stress-Activated Protein Kinase-1-Driven Nuclear Factor-{kappa}B Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity..
W. Vanden Berghe, N. Dijsselbloem, L. Vermeulen, M. N. Ndlovu, E. Boone, and G. Haegeman (2006)
Cancer Res. 66, 4852-4862
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Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-{kappa}B Activation and a Reciprocal Suppression of TGF-beta Signal Pathway.
Y. Ishida, T. Kondo, A. Kimura, K. Matsushima, and N. Mukaida (2006)
J. Immunol. 176, 5598-5606
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Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1{alpha}-Mediated NF-{kappa}B Activation and Down-Regulation of TRAF2 Expression.
P. Hu, Z. Han, A. D. Couvillon, R. J. Kaufman, and J. H. Exton (2006)
Mol. Cell. Biol. 26, 3071-3084
   Abstract »    Full Text »    PDF »
Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for immune-related molecules by central nervous system mixed glial cell cultures.
R P Lisak, J A Benjamins, B Bealmear, B Yao, S Land, L Nedelkoska, and D Skundric (2006)
Multiple Sclerosis 12, 149-168
   Abstract »    PDF »
Poly(ADP-ribose) Polymerase-1 Signaling to Mitochondria in Necrotic Cell Death Requires RIP1/TRAF2-mediated JNK1 Activation.
Y. Xu, S. Huang, Z.-G. Liu, and J. Han (2006)
J. Biol. Chem. 281, 8788-8795
   Abstract »    Full Text »    PDF »
Extracellular TNFR1 Release Requires the Calcium-dependent Formation of a Nucleobindin 2-ARTS-1 Complex.
A. Islam, B. Adamik, F. I. Hawari, G. Ma, F. N. Rouhani, J. Zhang, and S. J. Levine (2006)
J. Biol. Chem. 281, 6860-6873
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The MC160 Protein Expressed by the Dermatotropic Poxvirus Molluscum Contagiosum Virus Prevents Tumor Necrosis Factor Alpha-Induced NF-{kappa}B Activation via Inhibition of I Kappa Kinase Complex Formation.
D. B. Nichols and J. L. Shisler (2006)
J. Virol. 80, 578-586
   Abstract »    Full Text »    PDF »
The Molecular Perspective: Tumor Necrosis Factor.
D. S. Goodsell (2006)
Oncologist 11, 83-84
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TAK1 Is Recruited to the Tumor Necrosis Factor-{alpha} (TNF-{alpha}) Receptor 1 Complex in a Receptor-interacting Protein (RIP)-dependent Manner and Cooperates with MEKK3 Leading to NF-{kappa}B Activation.
M. Blonska, P. B. Shambharkar, M. Kobayashi, D. Zhang, H. Sakurai, B. Su, and X. Lin (2005)
J. Biol. Chem. 280, 43056-43063
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PAK4 Functions in Tumor Necrosis Factor (TNF) {alpha}-induced Survival Pathways by Facilitating TRADD Binding to the TNF Receptor.
X. Li and A. Minden (2005)
J. Biol. Chem. 280, 41192-41200
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Enhancement of Sensitivity to Tumor Necrosis Factor {alpha} in Non-Small Cell Lung Cancer Cells with Acquired Resistance to Gefitinib.
K. Ando, T. Ohmori, F. Inoue, T. Kadofuku, T. Hosaka, H. Ishida, T. Shirai, K. Okuda, T. Hirose, N. Horichi, et al. (2005)
Clin. Cancer Res. 11, 8872-8879
   Abstract »    Full Text »    PDF »
Molecular Determinants of Kinase Pathway Activation by Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand.
E. Varfolomeev, H. Maecker, D. Sharp, D. Lawrence, M. Renz, D. Vucic, and A. Ashkenazi (2005)
J. Biol. Chem. 280, 40599-40608
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Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD.
W. Matsuyama, H. Mitsuyama, M. Watanabe, K.-i. Oonakahara, I. Higashimoto, M. Osame, and K. Arimura (2005)
Chest 128, 3817-3827
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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
J.-H. Shim, C. Xiao, A. E. Paschal, S. T. Bailey, P. Rao, M. S. Hayden, K.-Y. Lee, C. Bussey, M. Steckel, N. Tanaka, et al. (2005)
Genes & Dev. 19, 2668-2681
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Distinct Role of Calmodulin and Calmodulin-dependent Protein Kinase-II in Lipopolysaccharide and Tumor Necrosis Factor-{alpha}-mediated Suppression of Apoptosis and Antiapoptotic c-IAP2 Gene Expression in Human Monocytic Cells.
S. Mishra, J. P. Mishra, K. Gee, D. C. McManus, E. C. LaCasse, and A. Kumar (2005)
J. Biol. Chem. 280, 37536-37546
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Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death.
T. Noguchi, K. Takeda, A. Matsuzawa, K. Saegusa, H. Nakano, J. Gohda, J.-i. Inoue, and H. Ichijo (2005)
J. Biol. Chem. 280, 37033-37040
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Mechanism for Removal of Tumor Necrosis Factor Receptor 1 from the Cell Surface by the Adenovirus RID{alpha}/{beta} Complex.
Y. R. Chin and M. S. Horwitz (2005)
J. Virol. 79, 13606-13617
   Abstract »    Full Text »    PDF »
Inhibition of Tumor Necrosis Factor-{alpha}-Induced RANTES Secretion by Alkaline Protease in A549 Cells.
T. M. Krunkosky, K. Maruo, J. Potempa, C. L. Jarrett, and J. Travis (2005)
Am. J. Respir. Cell Mol. Biol. 33, 483-489
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Tumor Necrosis Factor-{alpha} Triggers Mucus Production in Airway Epithelium through an I{kappa}B Kinase {beta}-dependent Mechanism.
J. M. Lora, D. M. Zhang, S. M. Liao, T. Burwell, A. M. King, P. A. Barker, L. Singh, M. Keaveney, J. Morgenstern, J. C. Gutierrez-Ramos, et al. (2005)
J. Biol. Chem. 280, 36510-36517
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Activation of Caspase 8 in the Pituitaries of Streptozotocin-Induced Diabetic Rats: Implication in Increased Apoptosis of Lactotrophs.
A. I. Arroba, L. M. Frago, J. Argente, and J. A. Chowen (2005)
Endocrinology 146, 4417-4424
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In Vivo Infusion of Interleukin-1{beta} and Chorionic Gonadotropin Induces Endometrial Changes that Mimic Early Pregnancy Events in the Baboon.
Z. Strakova, P. Mavrogianis, X. Meng, J. M. Hastings, K. S. Jackson, P. Cameo, A. Brudney, O. Knight, and A. T. Fazleabas (2005)
Endocrinology 146, 4097-4104
   Abstract »    Full Text »    PDF »

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