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Science 296 (5573): 1653-1655

Copyright © 2002 by the American Association for the Advancement of Science

A Road Map for Those Who Don't Know JAK-STAT

David S. Aaronson,1 Curt M. Horvath2*

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transmits information received from extracellular polypeptide signals, through transmembrane receptors, directly to target gene promoters in the nucleus, providing a mechanism for transcriptional regulation without second messengers. Evolutionarily conserved in eukaryotic organisms from slime molds to humans, JAK-STAT signaling appears to be an early adaptation to facilitate intercellular communication that has co-evolved with myriad cellular signaling events. This co-evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene expression. In addition, the JAK-STAT signaling pathways are regulated by a vast array of intrinsic and environmental stimuli, which can add plasticity to the response of a cell or tissue.

1 Department of Pharmacology and Biological Chemistry,
2 Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029 USA.
*   To whom correspondence should be addressed. E-mail: curt.horvath{at}

3Cpro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation.
Y. Du, J. Bi, J. Liu, X. Liu, X. Wu, P. Jiang, D. Yoo, Y. Zhang, J. Wu, R. Wan, et al. (2014)
J. Virol. 88, 4908-4920
   Abstract »    Full Text »    PDF »
Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor.
S. Gupta, M. Hirota, S. M. Waugh, I. Murakami, T. Suzuki, M. Muraguchi, M. Shibamori, Y. Ishikawa, T. C. Jarvis, J. D. Carter, et al. (2014)
J. Biol. Chem. 289, 8706-8719
   Abstract »    Full Text »    PDF »
Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-{kappa}B and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection.
J. Brownell, J. Bruckner, J. Wagoner, E. Thomas, Y.-M. Loo, M. Gale Jr., T. J. Liang, and S. J. Polyak (2014)
J. Virol. 88, 1582-1590
   Abstract »    Full Text »    PDF »
Cranberry Proanthocyanidins Improve Intestinal sIgA During Elemental Enteral Nutrition.
J. F. Pierre, A. F. Heneghan, R. P. Feliciano, D. Shanmuganayagam, C. G. Krueger, J. D. Reed, and K. A. Kudsk (2014)
JPEN J Parenter Enteral Nutr 38, 107-114
   Abstract »    Full Text »    PDF »
Ubiquitin-Specific Protease 13 Regulates IFN Signaling by Stabilizing STAT1.
H.-M. Yeh, C.-Y. Yu, H.-C. Yang, S.-H. Ko, C.-L. Liao, and Y.-L. Lin (2013)
J. Immunol. 191, 3328-3336
   Abstract »    Full Text »    PDF »
Candidate genes and single nucleotide polymorphisms associated with variation in residual feed intake in beef cattle.
B. K. Karisa, J. Thomson, Z. Wang, P. Stothard, S. S. Moore, and G. S. Plastow (2013)
J Anim Sci 91, 3502-3513
   Abstract »    Full Text »    PDF »
Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury.
I. B. Wanner, M. A. Anderson, B. Song, J. Levine, A. Fernandez, Z. Gray-Thompson, Y. Ao, and M. V. Sofroniew (2013)
J. Neurosci. 33, 12870-12886
   Abstract »    Full Text »    PDF »
BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes.
M. C. Patel, M. Debrosse, M. Smith, A. Dey, W. Huynh, N. Sarai, T. D. Heightman, T. Tamura, and K. Ozato (2013)
Mol. Cell. Biol. 33, 2497-2507
   Abstract »    Full Text »    PDF »
Molecular Pathways: Hepatitis C Virus, CXCL10, and the Inflammatory Road to Liver Cancer.
J. Brownell and S. J. Polyak (2013)
Clin. Cancer Res. 19, 1347-1352
   Abstract »    Full Text »    PDF »
Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread.
T. Mahlakoiv, D. Ritz, M. Mordstein, M. L. DeDiego, L. Enjuanes, M. A. Muller, C. Drosten, and P. Staeheli (2012)
J. Gen. Virol. 93, 2601-2605
   Abstract »    Full Text »    PDF »
Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies.
C. J. Carbone, H. Zheng, S. Bhattacharya, J. R. Lewis, A. M. Reiter, P. Henthorn, Z.-Y. Zhang, D. P. Baker, R. Ukkiramapandian, K. K. Bence, et al. (2012)
PNAS 109, 19226-19231
   Abstract »    Full Text »    PDF »
Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm.
E. Katsantoni (2012)
Science Signaling 5, pt13
   Abstract »    Full Text »    PDF »
Sphingosine Analogue AAL-R Increases TLR7-Mediated Dendritic Cell Responses via p38 and Type I IFN Signaling Pathways.
Y.-J. Seo, C. J. Pritzl, M. Vijayan, C. R. Blake, M. E. McClain, and B. Hahm (2012)
J. Immunol. 188, 4759-4768
   Abstract »    Full Text »    PDF »
A Method to Separate Nuclear, Cytosolic, and Membrane-Associated Signaling Molecules in Cultured Cells.
X. Liu and F. Fagotto (2011)
Science Signaling 4, pl2
   Abstract »    Full Text »    PDF »
Aloe vera Non-Decolorized Whole Leaf Extract-Induced Large Intestinal Tumors in F344 Rats Share Similar Molecular Pathways with Human Sporadic Colorectal Tumors.
A. R. Pandiri, R. C. Sills, M. J. Hoenerhoff, S. D. Peddada, T.-V. T. Ton, H.-H. L. Hong, G. P. Flake, D. E. Malarkey, G. R. Olson, I. P. Pogribny, et al. (2011)
Toxicol Pathol 39, 1065-1074
   Abstract »    Full Text »    PDF »
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
A. Takakura, E. A. Nelson, N. Haque, B. D. Humphreys, K. Zandi-Nejad, D. A. Frank, and J. Zhou (2011)
Hum. Mol. Genet. 20, 4143-4154
   Abstract »    Full Text »    PDF »
Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.
D. G. A. J. Hebels, D. G. J. Jennen, M. H. M. van Herwijnen, E. J. C. Moonen, M. Pedersen, L. E. Knudsen, J. C. S. Kleinjans, and T. M. C. M. de Kok (2011)
Mutagenesis 26, 753-761
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of Protein Kinase D2 Mediates Ligand-inducible Elimination of the Type 1 Interferon Receptor.
H. Zheng, J. Qian, D. P. Baker, and S. Y. Fuchs (2011)
J. Biol. Chem. 286, 35733-35741
   Abstract »    Full Text »    PDF »
Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN{alpha} via accelerating the degradation of its receptor.
S. Bhattacharya, H. Zheng, C. Tzimas, M. Carroll, D. P. Baker, and S. Y. Fuchs (2011)
Blood 118, 4179-4187
   Abstract »    Full Text »    PDF »
Molecular Mechanisms for Synchronized Transcription of Three Complement C1q Subunit Genes in Dendritic Cells and Macrophages.
G. Chen, C. S. Tan, B. K. Teh, and J. Lu (2011)
J. Biol. Chem. 286, 34941-34950
   Abstract »    Full Text »    PDF »
Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis.
H. Zheng, J. Qian, C. J. Carbone, N. A. Leu, D. P. Baker, and S. Y. Fuchs (2011)
Blood 118, 4003-4006
   Abstract »    Full Text »    PDF »
Suppression of STAT-1 Expression by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification and Plasmid Maintenance.
S. Hong, K. P. Mehta, and L. A. Laimins (2011)
J. Virol. 85, 9486-9494
   Abstract »    Full Text »    PDF »
Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor.
S. Bhattacharya, J. Qian, C. Tzimas, D. P. Baker, C. Koumenis, J. A. Diehl, and S. Y. Fuchs (2011)
J. Biol. Chem. 286, 22069-22076
   Abstract »    Full Text »    PDF »
Stat5: From Breast Development to Cancer Prognosis, Prediction, and Progression.
D. Tweardy and J. C. Chang (2011)
J. Clin. Oncol. 29, 2443-2444
   Full Text »    PDF »
6-Bromoindirubin-3'-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells.
L. Liu, S. Nam, Y. Tian, F. Yang, J. Wu, Y. Wang, A. Scuto, P. Polychronopoulos, P. Magiatis, L. Skaltsounis, et al. (2011)
Cancer Res. 71, 3972-3979
   Abstract »    Full Text »    PDF »
Cross-Talk Between Interferon-{gamma} and Hedgehog Signaling Regulates Adipogenesis.
J. Todoric, B. Strobl, A. Jais, N. Boucheron, M. Bayer, S. Amann, J. Lindroos, R. Teperino, G. Prager, M. Bilban, et al. (2011)
Diabetes 60, 1668-1676
   Abstract »    Full Text »    PDF »
Direct Effects of Type I Interferons on Cells of the Immune System.
S. Hervas-Stubbs, J. L. Perez-Gracia, A. Rouzaut, M. F. Sanmamed, A. Le Bon, and I. Melero (2011)
Clin. Cancer Res. 17, 2619-2627
   Abstract »    Full Text »    PDF »
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration.
F. M. Bareyre, N. Garzorz, C. Lang, T. Misgeld, H. Buning, and M. Kerschensteiner (2011)
PNAS 108, 6282-6287
   Abstract »    Full Text »    PDF »
Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3-Dependent NOSTRIN Expression.
M. E. McCormick, R. Goel, D. Fulton, S. Oess, D. Newman, and E. Tzima (2011)
Arterioscler Thromb Vasc Biol 31, 643-649
   Abstract »    Full Text »    PDF »
Ligand-Stimulated Downregulation of the Alpha Interferon Receptor: Role of Protein Kinase D2.
H. Zheng, J. Qian, B. Varghese, D. P. Baker, and S. Fuchs (2011)
Mol. Cell. Biol. 31, 710-720
   Abstract »    Full Text »    PDF »
MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop.
R. Ahmad, H. Rajabi, M. Kosugi, M. D. Joshi, M. Alam, B. Vasir, T. Kawano, S. Kharbanda, and D. Kufe (2011)
Science Signaling 4, ra9
   Abstract »    Full Text »    PDF »
Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK-STAT Pathway.
S.-B. Jeon, H. J. Yoon, C. Y. Chang, H. S. Koh, S.-H. Jeon, and E. J. Park (2010)
J. Immunol. 185, 7037-7046
   Abstract »    Full Text »    PDF »
Sphingosine 1-Phosphate-Metabolizing Enzymes Control Influenza Virus Propagation and Viral Cytopathogenicity.
Y.-J. Seo, C. Blake, S. Alexander, and B. Hahm (2010)
J. Virol. 84, 8124-8131
   Abstract »    Full Text »    PDF »
Combining the FLT3 Inhibitor PKC412 and the Triterpenoid CDDO-Me Synergistically Induces Apoptosis in Acute Myeloid Leukemia with the Internal Tandem Duplication Mutation.
R. Ahmad, S. Liu, E. Weisberg, E. Nelson, I. Galinsky, C. Meyer, D. Kufe, S. Kharbanda, and R. Stone (2010)
Mol. Cancer Res. 8, 986-993
   Abstract »    Full Text »    PDF »
Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1.
B. A. Creamer, K. Sakamoto, J. W. Schmidt, A. A. Triplett, R. Moriggl, and K. U. Wagner (2010)
Mol. Cell. Biol. 30, 2957-2970
   Abstract »    Full Text »    PDF »
Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor.
S. Bhattacharya, W.-C. HuangFu, J. Liu, S. Veeranki, D. P. Baker, C. Koumenis, J. A. Diehl, and S. Y. Fuchs (2010)
J. Biol. Chem. 285, 2318-2325
   Abstract »    Full Text »    PDF »
Mammalian Casein Kinase 1{alpha} and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling.
J. Liu, L. P. Carvalho, S. Bhattacharya, C. J. Carbone, K. G. S. Kumar, N. A. Leu, P. M. Yau, R. G. K. Donald, M. J. Weiss, D. P. Baker, et al. (2009)
Mol. Cell. Biol. 29, 6401-6412
   Abstract »    Full Text »    PDF »
The Macrophage Cholesterol Exporter ABCA1 Functions as an Anti-inflammatory Receptor.
C. Tang, Y. Liu, P. S. Kessler, A. M. Vaughan, and J. F. Oram (2009)
J. Biol. Chem. 284, 32336-32343
   Abstract »    Full Text »    PDF »
Src-dependent STAT-3-mediated Expression of Monocyte Chemoattractant Protein-1 Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-induced Vascular Smooth Muscle Cell Migration.
H. S. K. Potula, D. Wang, D. Van Quyen, N. K. Singh, V. Kundumani-Sridharan, M. Karpurapu, E. A. Park, W. C. Glasgow, and G. N. Rao (2009)
J. Biol. Chem. 284, 31142-31155
   Abstract »    Full Text »    PDF »
Dietary Saturated Fat Modulates the Association between STAT3 Polymorphisms and Abdominal Obesity in Adults.
C. M. Phillips, L. Goumidi, S. Bertrais, M. R. Field, G. M. Peloso, J. Shen, R. McManus, S. Hercberg, D. Lairon, R. Planells, et al. (2009)
J. Nutr. 139, 2011-2017
   Abstract »    Full Text »    PDF »
Hyperactivated B cells in human inflammatory bowel disease.
A. M. Noronha, Y. Liang, J. T. Hetzel, H. Hasturk, A. Kantarci, A. Stucchi, Y. Zhang, B. S. Nikolajczyk, F. A. Farraye, and L. M. Ganley-Leal (2009)
J. Leukoc. Biol. 86, 1007-1016
   Abstract »    Full Text »    PDF »
Reduction of Stat3 Activity Attenuates HIV-Induced Kidney Injury.
X. Feng, T.-C. Lu, P. Y. Chuang, W. Fang, K. Ratnam, H. Xiong, X. Ouyang, Y. Shen, D. E. Levy, D. Hyink, et al. (2009)
J. Am. Soc. Nephrol. 20, 2138-2146
   Abstract »    Full Text »    PDF »
Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma.
A. Navarro, T. Diaz, A. Martinez, A. Gaya, A. Pons, B. Gel, C. Codony, G. Ferrer, C. Martinez, E. Montserrat, et al. (2009)
Blood 114, 2945-2951
   Abstract »    Full Text »    PDF »
17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells.
Y. Wang, X. Ma, S. Yan, S. Shen, H. Zhu, Y. Gu, H. Wang, G. Qin, and Q. Yu (2009)
Cancer Res. 69, 7302-7310
   Abstract »    Full Text »    PDF »
Oncogenic EGFR Signaling Networks in Glioma.
P. H. Huang, A. M. Xu, and F. M. White (2009)
Science Signaling 2, re6
   Abstract »    Full Text »    PDF »
Synergistic Induction of Endothelin-1 by Tumor Necrosis Factor {alpha} and Interferon {gamma} Is due to Enhanced NF-{kappa}B Binding and Histone Acetylation at Specific {kappa}B Sites.
S. J. Wort, M. Ito, P.-C. Chou, S. K. Mc Master, R. Badiger, E. Jazrawi, P. de Souza, T. W. Evans, J. A. Mitchell, L. Pinhu, et al. (2009)
J. Biol. Chem. 284, 24297-24305
   Abstract »    Full Text »    PDF »
A Point Mutation, E95D, in the Mumps Virus V Protein Disengages STAT3 Targeting from STAT1 Targeting.
M. Puri, K. Lemon, W. P. Duprex, B. K. Rima, and C. M. Horvath (2009)
J. Virol. 83, 6347-6356
   Abstract »    Full Text »    PDF »
Gaussian process regression bootstrapping: exploring the effects of uncertainty in time course data.
P. D. W. Kirk and M. P. H. Stumpf (2009)
Bioinformatics 25, 1300-1306
   Abstract »    Full Text »    PDF »
Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities.
D. Uzri and L. Gehrke (2009)
J. Virol. 83, 4174-4184
   Abstract »    Full Text »    PDF »
A rapid simple approach to quantify chromosome conformation capture.
M. Abou El Hassan and R. Bremner (2009)
Nucleic Acids Res. 37, e35
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatases Regulate Asthma Development in a Murine Asthma Model.
P. Pouliot, P. Camateros, D. Radzioch, B. N. Lambrecht, and M. Olivier (2009)
J. Immunol. 182, 1334-1340
   Abstract »    Full Text »    PDF »
Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling.
S. Kaur, A. Sassano, A. M. Joseph, B. Majchrzak-Kita, E. A. Eklund, A. Verma, S. M. Brachmann, E. N. Fish, and L. C. Platanias (2008)
J. Immunol. 181, 7316-7323
   Abstract »    Full Text »    PDF »
SOCS-3 Inhibits E2F/DP-1 Transcriptional Activity and Cell Cycle Progression via Interaction with DP-1.
Y. Masuhiro, K. Kayama, A. Fukushima, K. Baba, M. Soutsu, Y. Kamiya, M. Gotoh, N. Yamaguchi, and S. Hanazawa (2008)
J. Biol. Chem. 283, 31575-31583
   Abstract »    Full Text »    PDF »
Interferon-{gamma} inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway.
M. Labeur, D. Refojo, B. Wolfel, J. Stalla, V. Vargas, M. Theodoropoulou, M. Buchfelder, M. Paez-Pereda, E. Arzt, and G. K Stalla (2008)
J. Endocrinol. 199, 177-189
   Abstract »    Full Text »    PDF »
BDNF Selectively Regulates GABAA Receptor Transcription by Activation of the JAK/STAT Pathway.
I. V. Lund, Y. Hu, Y. H. Raol, R. S. Benham, R. Faris, S. J. Russek, and A. R. Brooks-Kayal (2008)
Science Signaling 1, ra9
   Abstract »    Full Text »    PDF »
Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo.
K. Pandya, J. Cowhig, J. Brackhan, H. S. Kim, J. Hagaman, M. Rojas, C. W. Carter Jr, L. Mao, H. A. Rockman, N. Maeda, et al. (2008)
PNAS 105, 13063-13068
   Abstract »    Full Text »    PDF »
STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury.
J. E. Herrmann, T. Imura, B. Song, J. Qi, Y. Ao, T. K. Nguyen, R. A. Korsak, K. Takeda, S. Akira, and M. V. Sofroniew (2008)
J. Neurosci. 28, 7231-7243
   Abstract »    Full Text »    PDF »
Interleukin-6 as a Photoreceptor Neuroprotectant in an Experimental Model of Retinal Detachment.
D. Y. Chong, C. S. Boehlke, Q.-D. Zheng, L. Zhang, Y. Han, and D. N. Zacks (2008)
Invest. Ophthalmol. Vis. Sci. 49, 3193-3200
   Abstract »    Full Text »    PDF »
Henipavirus V Protein Association with Polo-Like Kinase Reveals Functional Overlap with STAT1 Binding and Interferon Evasion.
L. E. Ludlow, M. K. Lo, J. J. Rodriguez, P. A. Rota, and C. M. Horvath (2008)
J. Virol. 82, 6259-6271
   Abstract »    Full Text »    PDF »
Signal transducer and activator of transcription 5A/B in prostate and breast cancers.
S.-H. Tan and M. T Nevalainen (2008)
Endocr. Relat. Cancer 15, 367-390
   Abstract »    Full Text »    PDF »
Suppression of Interferon (IFN)-inducible Genes and IFN-mediated Functional Responses in BCR-ABL-expressing Cells.
E. Katsoulidis, A. Sassano, B. Majchrzak-Kita, N. Carayol, P. Yoon, A. Jordan, B. J. Druker, E. N. Fish, and L. C. Platanias (2008)
J. Biol. Chem. 283, 10793-10803
   Abstract »    Full Text »    PDF »
Triterpenoid CDDO-Methyl Ester Inhibits the Janus-Activated Kinase-1 (JAK1)->Signal Transducer and Activator of Transcription-3 (STAT3) Pathway by Direct Inhibition of JAK1 and STAT3.
R. Ahmad, D. Raina, C. Meyer, and D. Kufe (2008)
Cancer Res. 68, 2920-2926
   Abstract »    Full Text »    PDF »
Disease-Modifying Mutations in Familial Hypertrophic Cardiomyopathy: Complexity From Simplicity.
D. Hilfiker-Kleiner and R. Knoll (2008)
Circulation 117, 1775-1777
   Full Text »    PDF »
Phosphorylation of Human Jak3 at Tyrosines 904 and 939 Positively Regulates Its Activity.
H. Cheng, J. A. Ross, J. A. Frost, and R. A. Kirken (2008)
Mol. Cell. Biol. 28, 2271-2282
   Abstract »    Full Text »    PDF »
PDGF-C and -D Induced Proliferation/Migration of Human RPE Is Abolished by Inflammatory Cytokines.
R. Li, A. Maminishkis, F. E. Wang, and S. S. Miller (2007)
Invest. Ophthalmol. Vis. Sci. 48, 5722-5732
   Abstract »    Full Text »    PDF »
JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism.
K. L. Wu, H. Miao, and S. Khan (2007)
Am J Physiol Renal Physiol 293, F1836-F1846
   Abstract »    Full Text »    PDF »
Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period.
G. F Anhe, T. C A Nogueira, J. E Nicoletti-Carvalho, C. Lellis-Santos, H. C Barbosa, J. Cipolla-Neto, J. R Bosqueiro, A. C Boschero, and S. Bordin (2007)
J. Endocrinol. 195, 17-27
   Abstract »    Full Text »    PDF »
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
F. A. Masri, W. Xu, S. A. A. Comhair, K. Asosingh, M. Koo, A. Vasanji, J. Drazba, B. Anand-Apte, and S. C. Erzurum (2007)
Am J Physiol Lung Cell Mol Physiol 293, L548-L554
   Abstract »    Full Text »    PDF »
Laminar flow attenuates interferon-induced inflammatory responses in endothelial cells.
Y.-C. Tsai, H.-J. Hsieh, F. Liao, C.-W. Ni, Y.-J. Chao, C.-Y. Hsieh, and D. L. Wang (2007)
Cardiovasc Res 74, 497-505
   Abstract »    Full Text »    PDF »
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}.
A. Bourdeau, N. Dube, K. M. Heinonen, J.-F. Theberge, K. M. Doody, and M. L. Tremblay (2007)
Blood 109, 4220-4228
   Abstract »    Full Text »    PDF »
Modulation of Gamma Interferon Receptor 1 by Mycobacterium tuberculosis: a Potential Immune Response Evasive Mechanism.
A. Singhal, A. Jaiswal, V. K. Arora, and H. K. Prasad (2007)
Infect. Immun. 75, 2500-2510
   Abstract »    Full Text »    PDF »
Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells.
K. M.A. Rogers, M. Thomas, L. Galligan, T. R. Wilson, W. L. Allen, H. Sakai, P. G. Johnston, and D. B. Longley (2007)
Mol. Cancer Ther. 6, 1544-1551
   Abstract »    Full Text »    PDF »
Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells.
P. Liu, M. Jamaluddin, K. Li, R. P. Garofalo, A. Casola, and A. R. Brasier (2007)
J. Virol. 81, 1401-1411
   Abstract »    Full Text »    PDF »
IFN{gamma} synergizes with IL-1{beta} to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis.
J. E. Harris, M. Fernandez-Vilaseca, P. T. G. Elkington, D. E. Horncastle, M. B. Graeber, and J. S. Friedland (2007)
FASEB J 21, 356-365
   Abstract »    Full Text »    PDF »
Differential role of Jak-STAT signaling in retinal degenerations.
M. Samardzija, A. Wenzel, S. Aufenberg, M. Thiersch, C. Reme, and C. Grimm (2006)
FASEB J 20, 2411-2413
   Abstract »    Full Text »    PDF »
STAT1-Independent Cell Type-Specific Regulation of Antiviral APOBEC3G by IFN-{alpha}.
P. T. N. Sarkis, S. Ying, R. Xu, and X.-F. Yu (2006)
J. Immunol. 177, 4530-4540
   Abstract »    Full Text »    PDF »
Cloning of porcine signal transducer and activator of transcription 3 cDNA and its expression in reproductive tissues..
L. Wen, J. Craig, P. W Dyce, and J. Li (2006)
Reproduction 132, 511-518
   Abstract »    Full Text »    PDF »
Cardiac fibroblasts: friend or foe?.
T. A. Baudino, W. Carver, W. Giles, and T. K. Borg (2006)
Am J Physiol Heart Circ Physiol 291, H1015-H1026
   Abstract »    Full Text »    PDF »
Dendritic Cell Inhibition: Memoirs from Immunosuppressive Viruses.
M. J. Trifilo, B. Hahm, E. I. Zuniga, K. H. Edelmann, and M. B. A. Oldstone (2006)
The Journal of Infectious Disease 194, S3-S10
   Full Text »    PDF »
Haplotype of Signal Transducer and Activator of Transcription 3 Gene Predicts Cardiovascular Disease in Dialysis Patients.
L. Zhang, W.H. L. Kao, Y. Berthier-Schaad, Y. Liu, L. Plantinga, B. G. Jaar, N. Fink, N. Powe, M. J. Klag, M. W. Smith, et al. (2006)
J. Am. Soc. Nephrol. 17, 2285-2292
   Abstract »    Full Text »    PDF »
Arginine-Vasopressin Activates the JAK-STAT Pathway in Vascular Smooth Muscle Cells.
O. Levy and Y. Granot (2006)
J. Biol. Chem. 281, 15597-15604
   Abstract »    Full Text »    PDF »
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
O. A. Malakhova, K. I. Kim, J.-K. Luo, W. Zou, K. S. Kumar, S. Y. Fuchs, K. Shuai, and D.-E. Zhang (2006)
EMBO J. 25, 2358-2367
   Abstract »    Full Text »    PDF »
Cytokine-induced metabolic effects in human adipocytes are independent of endogenous nitric oxide.
P. Linscheid, D. Seboek, H. Zulewski, A. Scherberich, N. Blau, U. Keller, and B. Muller (2006)
Am J Physiol Endocrinol Metab 290, E1068-E1077
   Abstract »    Full Text »    PDF »
Tid1 Isoforms Are Mitochondrial DnaJ-like Chaperones with Unique Carboxyl Termini That Determine Cytosolic Fate.
B. Lu, N. Garrido, J. N. Spelbrink, and C. K. Suzuki (2006)
J. Biol. Chem. 281, 13150-13158
   Abstract »    Full Text »    PDF »
Inhibition of Interferon Signaling by Rabies Virus Phosphoprotein P: Activation-Dependent Binding of STAT1 and STAT2.
K. Brzozka, S. Finke, and K.-K. Conzelmann (2006)
J. Virol. 80, 2675-2683
   Abstract »    Full Text »    PDF »
A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling.
C. Paulus, S. Krauss, and M. Nevels (2006)
PNAS 103, 3840-3845
   Abstract »    Full Text »    PDF »
Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation.
A. M. Deschamps and F. G. Spinale (2006)
Cardiovasc Res 69, 666-676
   Abstract »    Full Text »    PDF »
Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas.
T. L. Lee, J. Yeh, C. Van Waes, and Z. Chen (2006)
Mol. Cancer Ther. 5, 8-19
   Abstract »    Full Text »    PDF »
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
Y. K. Lee, C. R. Isham, S. H. Kaufman, and K. C. Bible (2006)
Mol. Cancer Ther. 5, 138-148
   Abstract »    Full Text »    PDF »
A Distal Regulatory Region Is Required for Constitutive and IFN-{beta}-Induced Expression of Murine TLR9 Gene.
Z. Guo, S. Garg, K. M. Hill, L. Jayashankar, M. R. Mooney, M. Hoelscher, J. M. Katz, J. M. Boss, and S. Sambhara (2005)
J. Immunol. 175, 7407-7418
   Abstract »    Full Text »    PDF »
Rabies Virus P Protein Interacts with STAT1 and Inhibits Interferon Signal Transduction Pathways.
A. Vidy, M. Chelbi-Alix, and D. Blondel (2005)
J. Virol. 79, 14411-14420
   Abstract »    Full Text »    PDF »
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.
R. Kralovics, S.-S. Teo, A. S. Buser, M. Brutsche, R. Tiedt, A. Tichelli, F. Passamonti, D. Pietra, M. Cazzola, and R. C. Skoda (2005)
Blood 106, 3374-3376
   Abstract »    Full Text »    PDF »
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite.
M. Platten, P. P. Ho, S. Youssef, P. Fontoura, H. Garren, E. M. Hur, R. Gupta, L. Y. Lee, B. A. Kidd, W. H. Robinson, et al. (2005)
Science 310, 850-855
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non-Small Cell Lung Cancer.
H. Dalwadi, K. Krysan, N. Heuze-Vourc'h, M. Dohadwala, D. Elashoff, S. Sharma, N. Cacalano, A. Lichtenstein, and S. Dubinett (2005)
Clin. Cancer Res. 11, 7674-7682
   Abstract »    Full Text »    PDF »
Apical role for BRG1 in cytokine-induced promoter assembly.
Z. Ni, E. Karaskov, T. Yu, S. M. Callaghan, S. Der, D. S. Park, Z. Xu, S. G. Pattenden, and R. Bremner (2005)
PNAS 102, 14611-14616
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Attenuated Rabies Virus Activates, while Pathogenic Rabies Virus Evades, the Host Innate Immune Responses in the Central Nervous System.
Z. W. Wang, L. Sarmento, Y. Wang, X.-q. Li, V. Dhingra, T. Tseggai, B. Jiang, and Z. F. Fu (2005)
J. Virol. 79, 12554-12565
   Abstract »    Full Text »    PDF »

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