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Science 296 (5575): 2046-2049

Copyright © 2002 by the American Association for the Advancement of Science

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Andrea M. Peier,1 Alison J. Reeve,2 David A. Andersson,2 Aziz Moqrich,3 Taryn J. Earley,3 Anne C. Hergarden,1 Gina M. Story,3 Sian Colley,2 John B. Hogenesch,1 Peter McIntyre,2 Stuart Bevan,2 Ardem Patapoutian13*

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.

1 Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
2 Novartis Institute for Medical Sciences, London WC1E 6BN, UK.
3 Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: ardem{at}scripps.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    PDF »
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K. K. Rau, S. L. McIlwrath, H. Wang, J. J. Lawson, M. P. Jankowski, M. J. Zylka, D. J. Anderson, and H. R. Koerber (2009)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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K. Y. Kwan, J. M. Glazer, D. P. Corey, F. L. Rice, and C. L. Stucky (2009)
J. Neurosci. 29, 4808-4819
   Abstract »    Full Text »    PDF »
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J. Neurosci. 29, 1636-1647
   Abstract »    Full Text »    PDF »
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.
H. Hu, J. Grandl, M. Bandell, M. Petrus, and A. Patapoutian (2009)
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   Abstract »    Full Text »    PDF »
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T. Ohta, T. Imagawa, and S. Ito (2009)
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   Abstract »    Full Text »    PDF »
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S. M. Huang, H. Lee, M.-K. Chung, U. Park, Y. Y. Yu, H. B. Bradshaw, P. A. Coulombe, J. M. Walker, and M. J. Caterina (2008)
J. Neurosci. 28, 13727-13737
   Abstract »    Full Text »    PDF »
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function.
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   Abstract »    Full Text »    PDF »
Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster.
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   Abstract »    Full Text »    PDF »
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S. F. Morrison, K. Nakamura, and C. J. Madden (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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W. Liedtke (2007)
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   Abstract »    Full Text »    PDF »
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K. K. Rau, N. Jiang, R. D. Johnson, and B. Y. Cooper (2007)
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   Abstract »    Full Text »    PDF »
Thermosensitive TRPV Channel Subunits Coassemble into Heteromeric Channels with Intermediate Conductance and Gating Properties.
W. Cheng, F. Yang, C. L. Takanishi, and J. Zheng (2007)
J. Gen. Physiol. 129, 191-207
   Abstract »    Full Text »    PDF »
Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids.
D. A. Andersson, M. Nash, and S. Bevan (2007)
J. Neurosci. 27, 3347-3355
   Abstract »    Full Text »    PDF »
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
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Am J Physiol Regulatory Integrative Comp Physiol 292, R64-R76
   Abstract »    Full Text »    PDF »
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Y. Sun, M. Chen, B. H. Lowentritt, P. S. Van Zijl, K. R. Koch, S. Keay, J. M. Simard, and T. C. Chai (2007)
Am J Physiol Cell Physiol 292, C106-C114
   Abstract »    Full Text »    PDF »
Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.
W. Liedtke (2006)
J. Endocrinol. 191, 515-523
   Abstract »    Full Text »    PDF »
Evolution of thermoTRP ion channel homologs in vertebrates.
S. Saito and R. Shingai (2006)
Physiol Genomics 27, 219-230
   Abstract »    Full Text »    PDF »
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
   Abstract »    Full Text »    PDF »
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.
M. Y. Kochukov, T. A. McNearney, Y. Fu, and K. N. Westlund (2006)
Am J Physiol Cell Physiol 291, C424-C432
   Abstract »    Full Text »    PDF »
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels..
S. Brauchi, G. Orta, M. Salazar, E. Rosenmann, and R. Latorre (2006)
J. Neurosci. 26, 4835-4840
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels.
D. E. Clapham, D. Julius, C. Montell, and G. Schultz (2005)
Pharmacol. Rev. 57, 427-450
   Full Text »    PDF »
Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells.
S. Thebault, L. Lemonnier, G. Bidaux, M. Flourakis, A. Bavencoffe, D. Gordienko, M. Roudbaraki, P. Delcourt, Y. Panchin, Y. Shuba, et al. (2005)
J. Biol. Chem. 280, 39423-39435
   Abstract »    Full Text »    PDF »
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism.
H. Xu, N. T. Blair, and D. E. Clapham (2005)
J. Neurosci. 25, 8924-8937
   Abstract »    Full Text »    PDF »
Gating of TRP channels: a voltage connection?.
B. Nilius, K. Talavera, G. Owsianik, J. Prenen, G. Droogmans, and T. Voets (2005)
J. Physiol. 567, 35-44
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.
Q. Gu, R.-L. Lin, H.-Z. Hu, M. X. Zhu, and L.-Y. Lee (2005)
Am J Physiol Lung Cell Mol Physiol 288, L932-L941
   Abstract »    Full Text »    PDF »
Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3.
M.-K. Chung, A. D. Guler, and M. J. Caterina (2005)
J. Biol. Chem. 280, 15928-15941
   Abstract »    Full Text »    PDF »
TRPV1b, a Functional Human Vanilloid Receptor Splice Variant.
G. Lu, D. Henderson, L. Liu, P. H. Reinhart, and S. A. Simon (2005)
Mol. Pharmacol. 67, 1119-1127
   Abstract »    Full Text »    PDF »
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin.
A. Moqrich, S. W. Hwang, T. J. Earley, M. J. Petrus, A. N. Murray, K. S. R. Spencer, M. Andahazy, G. M. Story, and A. Patapoutian (2005)
Science 307, 1468-1472
   Abstract »    Full Text »    PDF »
The TRP Superfamily of Cation Channels.
C. Montell (2005)
Sci. STKE 2005, re3
   Abstract »    Full Text »    PDF »
Take a TRP to beat the heat.
M. J. Caterina and C. Montell (2005)
Genes & Dev. 19, 415-418
   Full Text »    PDF »
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4.
H. Lee, T. Iida, A. Mizuno, M. Suzuki, and M. J. Caterina (2005)
J. Neurosci. 25, 1304-1310
   Abstract »    Full Text »    PDF »
TRP Channels and Thermosensation.
A. Patapoutian (2005)
Chem Senses 30, i193-i194
   Full Text »    PDF »
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8.
S. Brauchi, P. Orio, and R. Latorre (2004)
PNAS 101, 15494-15499
   Abstract »    Full Text »    PDF »
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.
F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
   Abstract »    Full Text »    PDF »
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia.
H. Todaka, J. Taniguchi, J.-i. Satoh, A. Mizuno, and M. Suzuki (2004)
J. Biol. Chem. 279, 35133-35138
   Abstract »    Full Text »    PDF »
A TRPV2-PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells.
A. J. Stokes, L. M.N. Shimoda, M. Koblan-Huberson, C. N. Adra, and H. Turner (2004)
J. Exp. Med. 200, 137-147
   Abstract »    Full Text »    PDF »
Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses.
C. J. Woodbury, M. Zwick, S. Wang, J. J. Lawson, M. J. Caterina, M. Koltzenburg, K. M. Albers, H. R. Koerber, and B. M. Davis (2004)
J. Neurosci. 24, 6410-6415
   Abstract »    Full Text »    PDF »
The Transient Receptor Potential Superfamily of Ion Channels.
C.-L. Huang (2004)
J. Am. Soc. Nephrol. 15, 1690-1699
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3.
M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina (2004)
J. Neurosci. 24, 5177-5182
   Abstract »    Full Text »    PDF »
TRPV3 and TRPV4 Mediate Warmth-evoked Currents in Primary Mouse Keratinocytes.
M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina (2004)
J. Biol. Chem. 279, 21569-21575
   Abstract »    Full Text »    PDF »
Temperature-Triggered Periodical Thermogenic Oscillations in Skunk Cabbage (Symplocarpus foetidus).
K. Ito, T. Ito, Y. Onda, and M. Uemura (2004)
Plant Cell Physiol. 45, 257-264
   Abstract »    Full Text »    PDF »
TRPV4 calcium entry channel: a paradigm for gating diversity.
B. Nilius, J. Vriens, J. Prenen, G. Droogmans, and T. Voets (2004)
Am J Physiol Cell Physiol 286, C195-C205
   Abstract »    Full Text »    PDF »
The Vanilloid Receptor Family of Calcium-Permeable Channels: Molecular Integrators of Microenvironmental Stimuli.
R. G. O'Neil and R. C. Brown (2003)
Physiology 18, 226-231
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels.
D. E. Clapham, C. Montell, G. Schultz, and D. Julius (2003)
Pharmacol. Rev. 55, 591-596
   Abstract »    Full Text »    PDF »
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.
W. Liedtke, D. M. Tobin, C. I. Bargmann, and J. M. Friedman (2003)
PNAS 100, 14531-14536
   Abstract »    Full Text »
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.
J.-B. Peng, E. M Brown, and M. A Hediger (2003)
J. Physiol. 551, 729-740
   Abstract »    Full Text »    PDF »
Fever-like temperature induces maturation of dendritic cells through induction of hsp90.
S. Basu and P. K. Srivastava (2003)
Int. Immunol. 15, 1053-1061
   Abstract »    Full Text »    PDF »
Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes.
M.-K. Chung, H. Lee, and M. J. Caterina (2003)
J. Biol. Chem. 278, 32037-32046
   Abstract »    Full Text »    PDF »
Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site.
R. Strotmann, G. Schultz, and T. D. Plant (2003)
J. Biol. Chem. 278, 26541-26549
   Abstract »    Full Text »    PDF »
Temperature-modulated Diversity of TRPV4 Channel Gating: ACTIVATION BY PHYSICAL STRESSES AND PHORBOL ESTER DERIVATIVES THROUGH PROTEIN KINASE C-DEPENDENT AND -INDEPENDENT PATHWAYS.
X. Gao, L. Wu, and R. G. O'Neil (2003)
J. Biol. Chem. 278, 27129-27137
   Abstract »    Full Text »    PDF »
TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From Rat.
M. L. Nealen, M. S. Gold, P. D. Thut, and M. J. Caterina (2003)
J Neurophysiol 90, 515-520
   Abstract »    Full Text »    PDF »
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain.
J. D. Pomonis, J. E. Harrison, L. Mark, D. R. Bristol, K. J. Valenzano, and K. Walker (2003)
J. Pharmacol. Exp. Ther. 306, 387-393
   Abstract »    Full Text »    PDF »
A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity.
E. D. Prescott and D. Julius (2003)
Science 300, 1284-1288
   Abstract »    Full Text »    PDF »
Fast Ca2+-Induced Potentiation of Heat-Activated Ionic Currents Requires cAMP/PKA Signaling and Functional AKAP Anchoring.
C. Distler, P. K. Rathee, K. S. Lips, O. Obreja, W. Neuhuber, and M. Kress (2003)
J Neurophysiol 89, 2499-2505
   Abstract »    Full Text »    PDF »
Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation. SRC FAMILY KINASE-DEPENDENT TYROSINE PHOSPHORYLATION OF TRPV4 ON TYR-253 MEDIATES ITS RESPONSE TO HYPOTONIC STRESS.
H. Xu, H. Zhao, W. Tian, K. Yoshida, J.-B. Roullet, and D. M. Cohen (2003)
J. Biol. Chem. 278, 11520-11527
   Abstract »    Full Text »    PDF »
Functional Role of C-Terminal Cytoplasmic Tail of Rat Vanilloid Receptor 1.
V. Vlachova, J. Teisinger, K. Susankova, A. Lyfenko, R. Ettrich, and L. Vyklicky (2003)
J. Neurosci. 23, 1340-1350
   Abstract »    Full Text »    PDF »
Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes.
R. Guigo, E. T. Dermitzakis, P. Agarwal, C. P. Ponting, G. Parra, A. Reymond, J. F. Abril, E. Keibler, R. Lyle, C. Ucla, et al. (2003)
PNAS 100, 1140-1145
   Abstract »    Full Text »    PDF »
2002: Signaling Breakthroughs of the Year.
E. M. Adler, N. R. Gough, and L. B. Ray (2003)
Sci. STKE 2003, eg1
   Full Text »    PDF »
Differential Response Properties of IB4-Positive and -Negative Unmyelinated Sensory Neurons to Protons and Capsaicin.
S. Dirajlal, L. E. Pauers, and C. L. Stucky (2003)
J Neurophysiol 89, 513-524
   Abstract »    Full Text »    PDF »
The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain.
K. M. Walker, L. Urban, S. J. Medhurst, S. Patel, M. Panesar, A. J. Fox, and P. McIntyre (2003)
J. Pharmacol. Exp. Ther. 304, 56-62
   Abstract »    Full Text »    PDF »
Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells.
H. Watanabe, J. Vriens, S. H. Suh, C. D. Benham, G. Droogmans, and B. Nilius (2002)
J. Biol. Chem. 277, 47044-47051
   Abstract »    Full Text »    PDF »
GFR {alpha}2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons.
C. L Stucky, J. Rossi, M. S Airaksinen, and G. R Lewin (2002)
J. Physiol. 545, 43-50
   Abstract »    Full Text »    PDF »
Single-channel properties of native and cloned rat vanilloid receptors.
L. S Premkumar, S. Agarwal, and D. Steffen (2002)
J. Physiol. 545, 107-117
   Abstract »    Full Text »    PDF »

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