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Science 296 (5575): 2046-2049

Copyright © 2002 by the American Association for the Advancement of Science

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Andrea M. Peier,1 Alison J. Reeve,2 David A. Andersson,2 Aziz Moqrich,3 Taryn J. Earley,3 Anne C. Hergarden,1 Gina M. Story,3 Sian Colley,2 John B. Hogenesch,1 Peter McIntyre,2 Stuart Bevan,2 Ardem Patapoutian13*

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.

1 Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
2 Novartis Institute for Medical Sciences, London WC1E 6BN, UK.
3 Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: ardem{at}scripps.edu



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