Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 296 (5575): 2046-2049

Copyright © 2002 by the American Association for the Advancement of Science

A Heat-Sensitive TRP Channel Expressed in Keratinocytes

Andrea M. Peier,1 Alison J. Reeve,2 David A. Andersson,2 Aziz Moqrich,3 Taryn J. Earley,3 Anne C. Hergarden,1 Gina M. Story,3 Sian Colley,2 John B. Hogenesch,1 Peter McIntyre,2 Stuart Bevan,2 Ardem Patapoutian13*

Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.

1 Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
2 Novartis Institute for Medical Sciences, London WC1E 6BN, UK.
3 Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed. E-mail: ardem{at}

Camphor Activates and Sensitizes Transient Receptor Potential Melastatin 8 (TRPM8) to Cooling and Icilin.
T. Selescu, A. C. Ciobanu, C. Dobre, G. Reid, and A. Babes (2013)
Chem Senses 38, 563-575
   Abstract »    Full Text »    PDF »
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
C. Moore, F. Cevikbas, H. A. Pasolli, Y. Chen, W. Kong, C. Kempkes, P. Parekh, S. H. Lee, N.-A. Kontchou, I. Yeh, et al. (2013)
PNAS 110, E3225-E3234
   Abstract »    Full Text »    PDF »
Fat cells directly sense temperature to activate thermogenesis.
L. Ye, J. Wu, P. Cohen, L. Kazak, M. J. Khandekar, M. P. Jedrychowski, X. Zeng, S. P. Gygi, and B. M. Spiegelman (2013)
PNAS 110, 12480-12485
   Abstract »    Full Text »    PDF »
Changes in dermal interstitial ATP levels during local heating of human skin.
J. R. Gifford, C. Heal, J. Bridges, S. Goldthorpe, and G. W. Mack (2012)
J. Physiol. 590, 6403-6411
   Abstract »    Full Text »    PDF »
Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains.
S. N. Bagriantsev, K. A. Clark, and D. L. Minor Jr (2012)
EMBO J. 31, 3297-3308
   Abstract »    Full Text »    PDF »
Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of {alpha}-Hydroxyl Acids on Keratinocytes.
X. Cao, F. Yang, J. Zheng, and K. Wang (2012)
J. Biol. Chem. 287, 25905-25916
   Abstract »    Full Text »    PDF »
TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity.
T. Kusudo, Z. Wang, A. Mizuno, M. Suzuki, and H. Yamashita (2012)
J Appl Physiol 112, 1223-1232
   Abstract »    Full Text »    PDF »
Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response.
W. Cheng, F. Yang, S. Liu, C. K. Colton, C. Wang, Y. Cui, X. Cao, M. X. Zhu, C. Sun, K. Wang, et al. (2012)
J. Biol. Chem. 287, 7279-7288
   Abstract »    Full Text »    PDF »
Hysteresis of gating underlines sensitization of TRPV3 channels.
B. Liu, J. Yao, M. X. Zhu, and F. Qin (2011)
J. Gen. Physiol. 138, 509-520
   Abstract »    Full Text »    PDF »
Central circuitries for body temperature regulation and fever.
K. Nakamura (2011)
Am J Physiol Regulatory Integrative Comp Physiol 301, R1207-R1228
   Abstract »    Full Text »    PDF »
Perspectives on: Information and coding in mammalian sensory physiology: Probing mammalian touch transduction.
D. M. Bautista and E. A. Lumpkin (2011)
J. Gen. Physiol. 138, 291-301
   Full Text »    PDF »
Scraping through the ice: uncovering the role of TRPM8 in cold transduction.
D. D. McCoy, W. M. Knowlton, and D. D. McKemy (2011)
Am J Physiol Regulatory Integrative Comp Physiol 300, R1278-R1287
   Abstract »    Full Text »    PDF »
2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: Central neural pathways for thermoregulatory cold defense.
S. F. Morrison (2011)
J Appl Physiol 110, 1137-1149
   Abstract »    Full Text »    PDF »
Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.
J. F. Doerner, H. Hatt, and I. S. Ramsey (2011)
J. Gen. Physiol. 137, 271-288
   Abstract »    Full Text »    PDF »
Oral Epithelial Cells are Activated via TRP Channels.
B. Wang, A. Danjo, H. Kajiya, K. Okabe, and M. A. Kido (2011)
Journal of Dental Research 90, 163-167
   Abstract »    Full Text »    PDF »
The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling.
M. Gees, B. Colsoul, and B. Nilius (2010)
Cold Spring Harb Perspect Biol 2, a003962
   Abstract »    Full Text »    PDF »
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family.
L.-J. Wu, T.-B. Sweet, and D. E. Clapham (2010)
Pharmacol. Rev. 62, 381-404
   Abstract »    Full Text »    PDF »
Farnesyl Pyrophosphate Is a Novel Pain-producing Molecule via Specific Activation of TRPV3.
S. Bang, S. Yoo, T.-J. Yang, H. Cho, and S. W. Hwang (2010)
J. Biol. Chem. 285, 19362-19371
   Abstract »    Full Text »    PDF »
The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes.
T. Sokabe, T. Fukumi-Tominaga, S. Yonemura, A. Mizuno, and M. Tominaga (2010)
J. Biol. Chem. 285, 18749-18758
   Abstract »    Full Text »    PDF »
A Dietary Agonist of Transient Receptor Potential Cation Channel V3 Elicits Endothelium-Dependent Vasodilation.
S. Earley, A. L. Gonzales, and Z. I. Garcia (2010)
Mol. Pharmacol. 77, 612-620
   Abstract »    Full Text »    PDF »
Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain.
C. B. Phelps, R. R. Wang, S. S. Choo, and R. Gaudet (2010)
J. Biol. Chem. 285, 731-740
   Abstract »    Full Text »    PDF »
Odontoblast TRP Channels and Thermo/Mechanical Transmission.
A. R. Son, Y. M. Yang, J. H. Hong, S. I. Lee, Y. Shibukawa, and D. M. Shin (2009)
Journal of Dental Research 88, 1014-1019
   Abstract »    PDF »
Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors.
K. K. Rau, S. L. McIlwrath, H. Wang, J. J. Lawson, M. P. Jankowski, M. J. Zylka, D. J. Anderson, and H. R. Koerber (2009)
J. Neurosci. 29, 8612-8619
   Abstract »    Full Text »    PDF »
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels.
J. Vriens, G. Appendino, and B. Nilius (2009)
Mol. Pharmacol. 75, 1262-1279
   Abstract »    Full Text »    PDF »
TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons.
K. Y. Kwan, J. M. Glazer, D. P. Corey, F. L. Rice, and C. L. Stucky (2009)
J. Neurosci. 29, 4808-4819
   Abstract »    Full Text »    PDF »
Sensitization of Cutaneous Nociceptors after Nerve Transection and Regeneration: Possible Role of Target-Derived Neurotrophic Factor Signaling.
M. P. Jankowski, J. J. Lawson, S. L. McIlwrath, K. K. Rau, C. E. Anderson, K. M. Albers, and H. R. Koerber (2009)
J. Neurosci. 29, 1636-1647
   Abstract »    Full Text »    PDF »
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4.
H. Hu, J. Grandl, M. Bandell, M. Petrus, and A. Patapoutian (2009)
PNAS 106, 1626-1631
   Abstract »    Full Text »    PDF »
Involvement of Transient Receptor Potential Vanilloid Subtype 1 in Analgesic Action of Methylsalicylate.
T. Ohta, T. Imagawa, and S. Ito (2009)
Mol. Pharmacol. 75, 307-317
   Abstract »    Full Text »    PDF »
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2.
S. M. Huang, H. Lee, M.-K. Chung, U. Park, Y. Y. Yu, H. B. Bradshaw, P. A. Coulombe, J. M. Walker, and M. J. Caterina (2008)
J. Neurosci. 28, 13727-13737
   Abstract »    Full Text »    PDF »
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function.
D. A. Prober, S. Zimmerman, B. R. Myers, B. M. McDermott Jr, S.-H. Kim, S. Caron, J. Rihel, L. Solnica-Krezel, D. Julius, A. J. Hudspeth, et al. (2008)
J. Neurosci. 28, 10102-10110
   Abstract »    Full Text »    PDF »
Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster.
M. Rosenzweig, K. Kang, and P. A. Garrity (2008)
PNAS 105, 14668-14673
   Abstract »    Full Text »    PDF »
Central control of thermogenesis in mammals.
S. F. Morrison, K. Nakamura, and C. J. Madden (2008)
Exp Physiol 93, 773-797
   Abstract »    Full Text »    PDF »
Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations.
R. Xiao, J. Tang, C. Wang, C. K. Colton, J. Tian, and M. X. Zhu (2008)
J. Biol. Chem. 283, 6162-6174
   Abstract »    Full Text »    PDF »
Impaired Basal Thermal Homeostasis in Rats Lacking Capsaicin-sensitive Peripheral Small Sensory Neurons.
H. Yamashita, Z. Wang, Y. Wang, T. Furuyama, Y. Kontani, Y. Sato, and N. Mori (2008)
J. Biochem. 143, 385-393
   Abstract »    Full Text »    PDF »
Transient Receptor Potential Channels in Sensory Neurons Are Targets of the Antimycotic Agent Clotrimazole.
V. Meseguer, Y. Karashima, K. Talavera, D. D'Hoedt, T. Donovan-Rodriguez, F. Viana, B. Nilius, and T. Voets (2008)
J. Neurosci. 28, 576-586
   Abstract »    Full Text »    PDF »
Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses.
K. Tajino, K. Matsumura, K. Kosada, T. Shibakusa, K. Inoue, T. Fushiki, H. Hosokawa, and S. Kobayashi (2007)
Am J Physiol Regulatory Integrative Comp Physiol 293, R2128-R2135
   Abstract »    Full Text »    PDF »
Hydromineral Neuroendocrinology: Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals.
W. Liedtke (2007)
Exp Physiol 92, 507-512
   Abstract »    Full Text »    PDF »
Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 Protein.
K. K. Rau, N. Jiang, R. D. Johnson, and B. Y. Cooper (2007)
J Neurophysiol 97, 2651-2662
   Abstract »    Full Text »    PDF »
Thermosensitive TRPV Channel Subunits Coassemble into Heteromeric Channels with Intermediate Conductance and Gating Properties.
W. Cheng, F. Yang, C. L. Takanishi, and J. Zheng (2007)
J. Gen. Physiol. 129, 191-207
   Abstract »    Full Text »    PDF »
Modulation of the Cold-Activated Channel TRPM8 by Lysophospholipids and Polyunsaturated Fatty Acids.
D. A. Andersson, M. Nash, and S. Bevan (2007)
J. Neurosci. 27, 3347-3355
   Abstract »    Full Text »    PDF »
Transient receptor potential ion channels as participants in thermosensation and thermoregulation.
M. J. Caterina (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R64-R76
   Abstract »    Full Text »    PDF »
EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients.
Y. Sun, M. Chen, B. H. Lowentritt, P. S. Van Zijl, K. R. Koch, S. Keay, J. M. Simard, and T. C. Chai (2007)
Am J Physiol Cell Physiol 292, C106-C114
   Abstract »    Full Text »    PDF »
Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.
W. Liedtke (2006)
J. Endocrinol. 191, 515-523
   Abstract »    Full Text »    PDF »
Evolution of thermoTRP ion channel homologs in vertebrates.
S. Saito and R. Shingai (2006)
Physiol Genomics 27, 219-230
   Abstract »    Full Text »    PDF »
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ..
D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff (2006)
Physiol Rev 86, 1309-1379
   Abstract »    Full Text »    PDF »
Thermosensitive TRP ion channels mediate cytosolic calcium response in human synoviocytes.
M. Y. Kochukov, T. A. McNearney, Y. Fu, and K. N. Westlund (2006)
Am J Physiol Cell Physiol 291, C424-C432
   Abstract »    Full Text »    PDF »
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
K. Togashi, Y. Hara, T. Tominaga, T. Higashi, Y. Konishi, Y. Mori, and M. Tominaga (2006)
EMBO J. 25, 1804-1815
   Abstract »    Full Text »    PDF »
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels..
S. Brauchi, G. Orta, M. Salazar, E. Rosenmann, and R. Latorre (2006)
J. Neurosci. 26, 4835-4840
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels.
D. E. Clapham, D. Julius, C. Montell, and G. Schultz (2005)
Pharmacol. Rev. 57, 427-450
   Full Text »    PDF »
Novel Role of Cold/Menthol-sensitive Transient Receptor Potential Melastatine Family Member 8 (TRPM8) in the Activation of Store-operated Channels in LNCaP Human Prostate Cancer Epithelial Cells.
S. Thebault, L. Lemonnier, G. Bidaux, M. Flourakis, A. Bavencoffe, D. Gordienko, M. Roudbaraki, P. Delcourt, Y. Panchin, Y. Shuba, et al. (2005)
J. Biol. Chem. 280, 39423-39435
   Abstract »    Full Text »    PDF »
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism.
H. Xu, N. T. Blair, and D. E. Clapham (2005)
J. Neurosci. 25, 8924-8937
   Abstract »    Full Text »    PDF »
Gating of TRP channels: a voltage connection?.
B. Nilius, K. Talavera, G. Owsianik, J. Prenen, G. Droogmans, and T. Voets (2005)
J. Physiol. 567, 35-44
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.
Q. Gu, R.-L. Lin, H.-Z. Hu, M. X. Zhu, and L.-Y. Lee (2005)
Am J Physiol Lung Cell Mol Physiol 288, L932-L941
   Abstract »    Full Text »    PDF »
Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3.
M.-K. Chung, A. D. Guler, and M. J. Caterina (2005)
J. Biol. Chem. 280, 15928-15941
   Abstract »    Full Text »    PDF »
TRPV1b, a Functional Human Vanilloid Receptor Splice Variant.
G. Lu, D. Henderson, L. Liu, P. H. Reinhart, and S. A. Simon (2005)
Mol. Pharmacol. 67, 1119-1127
   Abstract »    Full Text »    PDF »
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin.
A. Moqrich, S. W. Hwang, T. J. Earley, M. J. Petrus, A. N. Murray, K. S. R. Spencer, M. Andahazy, G. M. Story, and A. Patapoutian (2005)
Science 307, 1468-1472
   Abstract »    Full Text »    PDF »
The TRP Superfamily of Cation Channels.
C. Montell (2005)
Sci. STKE 2005, re3
   Abstract »    Full Text »    PDF »
Take a TRP to beat the heat.
M. J. Caterina and C. Montell (2005)
Genes & Dev. 19, 415-418
   Full Text »    PDF »
Altered Thermal Selection Behavior in Mice Lacking Transient Receptor Potential Vanilloid 4.
H. Lee, T. Iida, A. Mizuno, M. Suzuki, and M. J. Caterina (2005)
J. Neurosci. 25, 1304-1310
   Abstract »    Full Text »    PDF »
TRP Channels and Thermosensation.
A. Patapoutian (2005)
Chem Senses 30, i193-i194
   Full Text »    PDF »
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8.
S. Brauchi, P. Orio, and R. Latorre (2004)
PNAS 101, 15494-15499
   Abstract »    Full Text »    PDF »
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.
F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
   Abstract »    Full Text »    PDF »
Warm Temperature-sensitive Transient Receptor Potential Vanilloid 4 (TRPV4) Plays an Essential Role in Thermal Hyperalgesia.
H. Todaka, J. Taniguchi, J.-i. Satoh, A. Mizuno, and M. Suzuki (2004)
J. Biol. Chem. 279, 35133-35138
   Abstract »    Full Text »    PDF »
A TRPV2-PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells.
A. J. Stokes, L. M.N. Shimoda, M. Koblan-Huberson, C. N. Adra, and H. Turner (2004)
J. Exp. Med. 200, 137-147
   Abstract »    Full Text »    PDF »
Nociceptors Lacking TRPV1 and TRPV2 Have Normal Heat Responses.
C. J. Woodbury, M. Zwick, S. Wang, J. J. Lawson, M. J. Caterina, M. Koltzenburg, K. M. Albers, H. R. Koerber, and B. M. Davis (2004)
J. Neurosci. 24, 6410-6415
   Abstract »    Full Text »    PDF »
The Transient Receptor Potential Superfamily of Ion Channels.
C.-L. Huang (2004)
J. Am. Soc. Nephrol. 15, 1690-1699
   Abstract »    Full Text »    PDF »
2-Aminoethoxydiphenyl Borate Activates and Sensitizes the Heat-Gated Ion Channel TRPV3.
M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina (2004)
J. Neurosci. 24, 5177-5182
   Abstract »    Full Text »    PDF »
TRPV3 and TRPV4 Mediate Warmth-evoked Currents in Primary Mouse Keratinocytes.
M.-K. Chung, H. Lee, A. Mizuno, M. Suzuki, and M. J. Caterina (2004)
J. Biol. Chem. 279, 21569-21575
   Abstract »    Full Text »    PDF »
Temperature-Triggered Periodical Thermogenic Oscillations in Skunk Cabbage (Symplocarpus foetidus).
K. Ito, T. Ito, Y. Onda, and M. Uemura (2004)
Plant Cell Physiol. 45, 257-264
   Abstract »    Full Text »    PDF »
TRPV4 calcium entry channel: a paradigm for gating diversity.
B. Nilius, J. Vriens, J. Prenen, G. Droogmans, and T. Voets (2004)
Am J Physiol Cell Physiol 286, C195-C205
   Abstract »    Full Text »    PDF »
The Vanilloid Receptor Family of Calcium-Permeable Channels: Molecular Integrators of Microenvironmental Stimuli.
R. G. O'Neil and R. C. Brown (2003)
Physiology 18, 226-231
   Abstract »    Full Text »    PDF »
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels.
D. E. Clapham, C. Montell, G. Schultz, and D. Julius (2003)
Pharmacol. Rev. 55, 591-596
   Abstract »    Full Text »    PDF »
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.
W. Liedtke, D. M. Tobin, C. I. Bargmann, and J. M. Friedman (2003)
PNAS 100, 14531-14536
   Abstract »    Full Text »
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.
J.-B. Peng, E. M Brown, and M. A Hediger (2003)
J. Physiol. 551, 729-740
   Abstract »    Full Text »    PDF »
Fever-like temperature induces maturation of dendritic cells through induction of hsp90.
S. Basu and P. K. Srivastava (2003)
Int. Immunol. 15, 1053-1061
   Abstract »    Full Text »    PDF »
Warm Temperatures Activate TRPV4 in Mouse 308 Keratinocytes.
M.-K. Chung, H. Lee, and M. J. Caterina (2003)
J. Biol. Chem. 278, 32037-32046
   Abstract »    Full Text »    PDF »
Ca2+-dependent Potentiation of the Nonselective Cation Channel TRPV4 Is Mediated by a C-terminal Calmodulin Binding Site.
R. Strotmann, G. Schultz, and T. D. Plant (2003)
J. Biol. Chem. 278, 26541-26549
   Abstract »    Full Text »    PDF »
X. Gao, L. Wu, and R. G. O'Neil (2003)
J. Biol. Chem. 278, 27129-27137
   Abstract »    Full Text »    PDF »
TRPM8 mRNA Is Expressed in a Subset of Cold-Responsive Trigeminal Neurons From Rat.
M. L. Nealen, M. S. Gold, P. D. Thut, and M. J. Caterina (2003)
J Neurophysiol 90, 515-520
   Abstract »    Full Text »    PDF »
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain.
J. D. Pomonis, J. E. Harrison, L. Mark, D. R. Bristol, K. J. Valenzano, and K. Walker (2003)
J. Pharmacol. Exp. Ther. 306, 387-393
   Abstract »    Full Text »    PDF »
A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity.
E. D. Prescott and D. Julius (2003)
Science 300, 1284-1288
   Abstract »    Full Text »    PDF »
Fast Ca2+-Induced Potentiation of Heat-Activated Ionic Currents Requires cAMP/PKA Signaling and Functional AKAP Anchoring.
C. Distler, P. K. Rathee, K. S. Lips, O. Obreja, W. Neuhuber, and M. Kress (2003)
J Neurophysiol 89, 2499-2505
   Abstract »    Full Text »    PDF »
H. Xu, H. Zhao, W. Tian, K. Yoshida, J.-B. Roullet, and D. M. Cohen (2003)
J. Biol. Chem. 278, 11520-11527
   Abstract »    Full Text »    PDF »
Functional Role of C-Terminal Cytoplasmic Tail of Rat Vanilloid Receptor 1.
V. Vlachova, J. Teisinger, K. Susankova, A. Lyfenko, R. Ettrich, and L. Vyklicky (2003)
J. Neurosci. 23, 1340-1350
   Abstract »    Full Text »    PDF »
Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genes.
R. Guigo, E. T. Dermitzakis, P. Agarwal, C. P. Ponting, G. Parra, A. Reymond, J. F. Abril, E. Keibler, R. Lyle, C. Ucla, et al. (2003)
PNAS 100, 1140-1145
   Abstract »    Full Text »    PDF »
2002: Signaling Breakthroughs of the Year.
E. M. Adler, N. R. Gough, and L. B. Ray (2003)
Sci. STKE 2003, eg1
   Full Text »    PDF »
Differential Response Properties of IB4-Positive and -Negative Unmyelinated Sensory Neurons to Protons and Capsaicin.
S. Dirajlal, L. E. Pauers, and C. L. Stucky (2003)
J Neurophysiol 89, 513-524
   Abstract »    Full Text »    PDF »
The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain.
K. M. Walker, L. Urban, S. J. Medhurst, S. Patel, M. Panesar, A. J. Fox, and P. McIntyre (2003)
J. Pharmacol. Exp. Ther. 304, 56-62
   Abstract »    Full Text »    PDF »
Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells.
H. Watanabe, J. Vriens, S. H. Suh, C. D. Benham, G. Droogmans, and B. Nilius (2002)
J. Biol. Chem. 277, 47044-47051
   Abstract »    Full Text »    PDF »
GFR {alpha}2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons.
C. L Stucky, J. Rossi, M. S Airaksinen, and G. R Lewin (2002)
J. Physiol. 545, 43-50
   Abstract »    Full Text »    PDF »
Single-channel properties of native and cloned rat vanilloid receptors.
L. S Premkumar, S. Agarwal, and D. Steffen (2002)
J. Physiol. 545, 107-117
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882