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Science 296 (5576): 2238-2243

Copyright © 2002 by the American Association for the Advancement of Science

Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

Anthone W. Dunah,1 Hyunkyung Jeong,1 April Griffin,1 Yong-Man Kim,2 David G. Standaert,1 Steven M. Hersch,1 M. Maral Mouradian,2 Anne B. Young,1 Naoko Tanese,3 Dimitri Krainc1*

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis. Here, we report that huntingtin interacts with the transcriptional activator Sp1 and coactivator TAFII130. Coexpression of Sp1 and TAFII130 in cultured striatal cells from wild-type and HD transgenic mice reverses the transcriptional inhibition of the dopamine D2 receptor gene caused by mutant huntingtin, as well as protects neurons from huntingtin-induced cellular toxicity. Furthermore, soluble mutant huntingtin inhibits Sp1 binding to DNA in postmortem brain tissues of both presymptomatic and affected HD patients. Understanding these early molecular events in HD may provide an opportunity to interfere with the effects of mutant huntingtin before the development of disease symptoms.

1 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Center for Aging, Genetics and Neurodegeneration, Charlestown, MA 02129, USA.
2 Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, MSC 1406, Bethesda, MD 20892-1406, USA.
3 Department of Microbiology/MSB258, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
*   To whom correspondence should be addressed. E-mail: krainc{at}helix.mgh.harvard.edu



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Hum. Mol. Genet. 14, 179-189
   Abstract »    Full Text »    PDF »
The Repressor Element Silencing Transcription Factor (REST)-mediated Transcriptional Repression Requires the Inhibition of Sp1.
V. Plaisance, G. Niederhauser, F. Azzouz, V. Lenain, J.-A. Haefliger, G. Waeber, and A. Abderrahmani (2005)
J. Biol. Chem. 280, 401-407
   Abstract »    Full Text »    PDF »
Neuroprotective Effects of Phenylbutyrate in the N171-82Q Transgenic Mouse Model of Huntington's Disease.
G. Gardian, S. E. Browne, D.-K. Choi, P. Klivenyi, J. Gregorio, J. K. Kubilus, H. Ryu, B. Langley, R. R. Ratan, R. J. Ferrante, et al. (2005)
J. Biol. Chem. 280, 556-563
   Abstract »    Full Text »    PDF »
Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease.
R. J. Ferrante, H. Ryu, J. K. Kubilus, S. D'Mello, K. L. Sugars, J. Lee, P. Lu, K. Smith, S. Browne, M. F. Beal, et al. (2004)
J. Neurosci. 24, 10335-10342
   Abstract »    Full Text »    PDF »
Trinucleotide repeats and neurodegenerative disease.
C. M. Everett and N. W. Wood (2004)
Brain 127, 2385-2405
   Abstract »    Full Text »    PDF »
Huntingtin and the molecular pathogenesis of Huntington's disease: Fourth in Molecular Medicine Review Series.
C. Landles and G. P. Bates (2004)
EMBO Rep. 5, 958-963
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Huntington and its Role in Neuronal Degeneration.
S.-H. Li and X.-J. Li (2004)
Neuroscientist 10, 467-475
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