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Science 296 (5577): 2391-2394

Copyright © 2002 by the American Association for the Advancement of Science

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

Jason P. Eiserich,123*dagger Stephan Baldus,23*ddagger Marie-Luise Brennan,6 Wenxin Ma,4 Chunxiang Zhang,4 Albert Tousson,5 Laura Castro,23 Aldons J. Lusis,6 William M. Nauseef,7 C. Roger White,34 Bruce A. Freeman23dagger

Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans deficient in MPO are not at unusual risk of infection. MPO was observed herein to modulate the vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation. After leukocyte degranulation, MPO localized in and around vascular endothelial cells in a rodent model of acute endotoxemia and impaired endothelium-dependent relaxant responses, to which MPO-deficient mice were resistant. Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability.

1 Department of Internal Medicine, Division of Nephrology, and Department of Human Physiology, University of California, Davis, CA 95616, USA.
2 Department of Anesthesiology,
3 Center for Free Radical Biology,
4 Department of Medicine, and
5 Imaging Facility, University of Alabama, Birmingham, AL 35233, USA.
6 Department of Microbiology and Molecular Genetics and Department of Medicine, University of California, Los Angeles, CA 90095, USA.
7 Department of Medicine and the Inflammation Program, Veterans Administration Medical Center and University of Iowa, Iowa City, IA 52242, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: jpeiserich{at}ucdavis.edu or bruce.freeman{at}ccc.uab.edu

ddagger    Present address: Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany.



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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Biol. Chem. 279, 49567-49570
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. Stocker and J. F. Keaney Jr. (2004)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. Panteghini (2004)
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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J. H. Schwartz, C. A. White, and B. A. Freeman (2004)
Am J Physiol Lung Cell Mol Physiol 286, L701-L704
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The Role of Oxidative Stress-Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction.
G. A. Kaysen and J. P. Eiserich (2004)
J. Am. Soc. Nephrol. 15, 538-548
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Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
M. M. Tarpey, D. A. Wink, and M. B. Grisham (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R431-R444
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Peroxisome Proliferator-activated Receptor {gamma} Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism.
A. P. Kumar, F. J. Piedrafita, and W. F. Reynolds (2004)
J. Biol. Chem. 279, 8300-8315
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Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition.
S. Galijasevic, G. M. Saed, M. P. Diamond, and H. M. Abu-Soud (2003)
PNAS 100, 14766-14771
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Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases.
C. Zhang, J. Yang, J. D. Jacobs, and L. K. Jennings (2003)
Am J Physiol Heart Circ Physiol 285, H2563-H2572
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Reactive Oxygen Species in the Vasculature: Molecular and Cellular Mechanisms.
Y. Taniyama and K. K. Griendling (2003)
Hypertension 42, 1075-1081
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Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies.
K. K. Griendling and G. A. FitzGerald (2003)
Circulation 108, 2034-2040
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Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1.
S. Mutze, U. Hebling, W. Stremmel, J. Wang, J. Arnhold, K. Pantopoulos, and S. Mueller (2003)
J. Biol. Chem. 278, 40542-40549
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Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes.
S. Baldus, C. Heeschen, T. Meinertz, A. M. Zeiher, J. P. Eiserich, T. Munzel, M. L. Simoons, C. W. Hamm, and on behalf of the CAPTURE Investigators (2003)
Circulation 108, 1440-1445
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Coronary Artery Disease in End-Stage Renal Disease: No Longer a Simple Plumbing Problem.
P. Stenvinkel, R. Pecoits-Filho, and B. Lindholm (2003)
J. Am. Soc. Nephrol. 14, 1927-1939
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The Pickering Lecture British Hypertension Society, 10th September 2002: Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
D. G Harrison, Hua Cai, U. Landmesser, and K. K Griendling (2003)
Journal of Renin-Angiotensin-Aldosterone System 4, 51-61
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Preference Toward a T-Helper Type 1 Response in Patients With Coronary Spastic Angina.
H. Soejima, A. Irie, S. Miyamoto, I. Kajiwara, S. Kojima, J. Hokamaki, T. Sakamoto, T. Tanaka, M. Yoshimura, Y. Nishimura, et al. (2003)
Circulation 107, 2196-2200
   Abstract »    Full Text »    PDF »

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