Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 296 (5577): 2391-2394

Copyright © 2002 by the American Association for the Advancement of Science

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

Jason P. Eiserich,123*dagger Stephan Baldus,23*ddagger Marie-Luise Brennan,6 Wenxin Ma,4 Chunxiang Zhang,4 Albert Tousson,5 Laura Castro,23 Aldons J. Lusis,6 William M. Nauseef,7 C. Roger White,34 Bruce A. Freeman23dagger

Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. Although its microbicidal functions are well established in vitro, humans deficient in MPO are not at unusual risk of infection. MPO was observed herein to modulate the vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation. After leukocyte degranulation, MPO localized in and around vascular endothelial cells in a rodent model of acute endotoxemia and impaired endothelium-dependent relaxant responses, to which MPO-deficient mice were resistant. Altered vascular responsiveness was due to catalytic consumption of NO by substrate radicals generated by MPO. Thus MPO can directly modulate vascular inflammatory responses by regulating NO bioavailability.

1 Department of Internal Medicine, Division of Nephrology, and Department of Human Physiology, University of California, Davis, CA 95616, USA.
2 Department of Anesthesiology,
3 Center for Free Radical Biology,
4 Department of Medicine, and
5 Imaging Facility, University of Alabama, Birmingham, AL 35233, USA.
6 Department of Microbiology and Molecular Genetics and Department of Medicine, University of California, Los Angeles, CA 90095, USA.
7 Department of Medicine and the Inflammation Program, Veterans Administration Medical Center and University of Iowa, Iowa City, IA 52242, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: jpeiserich{at} or bruce.freeman{at}

ddagger    Present address: Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany.

Myeloperoxidase influences the complement regulatory function of modified C-reactive protein.
P.-c. Xu, Z.-y. Li, X.-w. Yang, M.-h. Zhao, and M. Chen (2014)
Innate Immunity 20, 440-448
   Abstract »    Full Text »    PDF »
Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo.
R. Carnemolla, C. F. Greineder, A.-M. Chacko, K. R. Patel, B.-S. Ding, S. Zaitsev, C. T. Esmon, and V. R. Muzykantov (2013)
J. Pharmacol. Exp. Ther. 347, 339-345
   Abstract »    Full Text »    PDF »
Neutrophils Amplify Autoimmune Central Nervous System Infiltrates by Maturing Local APCs.
K. Steinbach, M. Piedavent, S. Bauer, J. T. Neumann, and M. A. Friese (2013)
J. Immunol. 191, 4531-4539
   Abstract »    Full Text »    PDF »
Myeloperoxidase modulates human platelet aggregation via actin cytoskeleton reorganization and store-operated calcium entry.
I. V. Gorudko, A. V. Sokolov, E. V. Shamova, N. A. Grudinina, E. S. Drozd, L. M. Shishlo, D. V. Grigorieva, S. B. Bushuk, B. A. Bushuk, S. A. Chizhik, et al. (2013)
Biology Open 2, 916-923
   Abstract »    Full Text »    PDF »
Peroxynitrite, a Stealthy Biological Oxidant.
R. Radi (2013)
J. Biol. Chem. 288, 26464-26472
   Abstract »    Full Text »    PDF »
{beta}2 Integrin-mediated Cell-Cell Contact Transfers Active Myeloperoxidase from Neutrophils to Endothelial Cells.
U. Jerke, S. Rolle, B. Purfurst, F. C. Luft, W. M. Nauseef, and R. Kettritz (2013)
J. Biol. Chem. 288, 12910-12919
   Abstract »    Full Text »    PDF »
Myeloperoxidase: a front-line defender against phagocytosed microorganisms.
S. J. Klebanoff, A. J. Kettle, H. Rosen, C. C. Winterbourn, and W. M. Nauseef (2013)
J. Leukoc. Biol. 93, 185-198
   Abstract »    Full Text »    PDF »
Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children.
J. Olza, C. M. Aguilera, M. Gil-Campos, R. Leis, G. Bueno, M. D. Martinez-Jimenez, M. Valle, R. Canete, R. Tojo, L. A. Moreno, et al. (2012)
Diabetes Care 35, 2373-2376
   Abstract »    Full Text »    PDF »
Diagnostic and Prognostic Performance of Myeloperoxidase Plasma Levels Compared With Sensitive Troponins in Patients Admitted With Acute Onset Chest Pain.
V. Rudolph, T. Keller, A. Schulz, F. Ojeda, T. K. Rudolph, S. Tzikas, C. Bickel, T. Meinertz, T. Munzel, S. Blankenberg, et al. (2012)
Circ Cardiovasc Genet 5, 561-568
   Abstract »    Full Text »    PDF »
Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension.
K. Asosingh, S. Farha, A. Lichtin, B. Graham, D. George, M. Aldred, S. L. Hazen, J. Loyd, R. Tuder, and S. C. Erzurum (2012)
Blood 120, 1218-1227
   Abstract »    Full Text »    PDF »
Myeloperoxidase deficiency preserves vasomotor function in humans.
T. K. Rudolph, S. Wipper, B. Reiter, V. Rudolph, A. Coym, C. Detter, D. Lau, A. Klinke, K. Friedrichs, T. Rau, et al. (2012)
Eur. Heart J. 33, 1625-1634
   Abstract »    Full Text »    PDF »
Clinical and Genetic Association of Serum Ceruloplasmin With Cardiovascular Risk.
W. H. Wilson Tang, Y. Wu, J. Hartiala, Y. Fan, A. F. R. Stewart, R. Roberts, R. McPherson, P. L. Fox, H. Allayee, and S. L. Hazen (2012)
Arterioscler Thromb Vasc Biol 32, 516-522
   Abstract »    Full Text »    PDF »
Risk Prediction with Serial Myeloperoxidase Monitoring in Patients with Acute Chest Pain.
S. J. Nicholls, W. H. Wilson Tang, D. Brennan, M.-L. Brennan, S. Mann, S. E. Nissen, and S. L. Hazen (2011)
Clin. Chem. 57, 1762-1770
   Abstract »    Full Text »    PDF »
Increased Survival and Reduced Neutrophil Infiltration of the Liver in Rab27a- but Not Munc13-4-Deficient Mice in Lipopolysaccharide-Induced Systemic Inflammation.
J. L. Johnson, H. Hong, J. Monfregola, and S. D. Catz (2011)
Infect. Immun. 79, 3607-3618
   Abstract »    Full Text »    PDF »
Urate as a Physiological Substrate for Myeloperoxidase: IMPLICATIONS FOR HYPERURICEMIA AND INFLAMMATION.
F. C. Meotti, G. N. L. Jameson, R. Turner, D. T. Harwood, S. Stockwell, M. D. Rees, S. R. Thomas, and A. J. Kettle (2011)
J. Biol. Chem. 286, 12901-12911
   Abstract »    Full Text »    PDF »
Brachial artery low-flow-mediated constriction is increased early after coronary intervention and reduces during recovery after acute coronary syndrome: characterization of a recently described index of vascular function.
J. R. Spiro, J. E. Digby, G. Ghimire, M. Mason, A. G. Mitchell, C. Ilsley, A. Donald, M. C. D. Dalby, and R. K. Kharbanda (2011)
Eur. Heart J. 32, 856-866
   Abstract »    Full Text »    PDF »
Assessment of multiple cardiac biomarkers in non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 Trial.
B. M. Scirica, M. S. Sabatine, P. Jarolim, S. A. Murphy, J. L. de Lemos, E. Braunwald, and D. A. Morrow (2011)
Eur. Heart J. 32, 697-705
   Abstract »    Full Text »    PDF »
MPO and neutrophils: a magnetic attraction.
M. J. Hickey (2011)
Blood 117, 1103-1104
   Full Text »    PDF »
Myeloperoxidase attracts neutrophils by physical forces.
A. Klinke, C. Nussbaum, L. Kubala, K. Friedrichs, T. K. Rudolph, V. Rudolph, H.-J. Paust, C. Schroder, D. Benten, D. Lau, et al. (2011)
Blood 117, 1350-1358
   Abstract »    Full Text »    PDF »
Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis.
M. Drechsler, R. T. A. Megens, M. van Zandvoort, C. Weber, and O. Soehnlein (2010)
Circulation 122, 1837-1845
   Abstract »    Full Text »    PDF »
Myeloperoxidase Expression as a Potential Determinant of Parthenolide-Induced Apoptosis in Leukemia Bulk and Leukemia Stem Cells.
Y. R. Kim, J. I. Eom, S. J. Kim, H. K. Jeung, J.-W. Cheong, J. S. Kim, and Y. H. Min (2010)
J. Pharmacol. Exp. Ther. 335, 389-400
   Abstract »    Full Text »    PDF »
Delivery of SAR 1118 to the Retina via Ophthalmic Drops and its Effectiveness in a Rat Streptozotocin (STZ) Model of Diabetic Retinopathy (DR).
V. R. Rao, E. Prescott, N. B. Shelke, R. Trivedi, P. Thomas, C. Struble, T. Gadek, C. A. O'Neill, and U. B. Kompella (2010)
Invest. Ophthalmol. Vis. Sci. 51, 5198-5204
   Abstract »    Full Text »    PDF »
Free Fatty Acid Causes Leukocyte Activation and Resultant Endothelial Dysfunction Through Enhanced Angiotensin II Production in Mononuclear and Polymorphonuclear Cells.
Y. Azekoshi, T. Yasu, S. Watanabe, T. Tagawa, S. Abe, K. Yamakawa, Y. Uehara, S. Momomura, H. Urata, and S. Ueda (2010)
Hypertension 56, 136-142
   Abstract »    Full Text »    PDF »
Myeloperoxidase for Guiding Therapy for Acute Cardiac Decompensation? It's Heart to Tell.
V. Rudolph and S. Baldus (2010)
Clin. Chem. 56, 881-882
   Full Text »    PDF »
Use of Myeloperoxidase for Risk Stratification in Acute Heart Failure.
T. Reichlin, T. Socrates, P. Egli, M. Potocki, T. Breidthardt, N. Arenja, J. Meissner, M. Noveanu, M. Reiter, R. Twerenbold, et al. (2010)
Clin. Chem. 56, 944-951
   Abstract »    Full Text »    PDF »
Neutrophil Infiltration and Systemic Vascular Inflammation in Obese Women.
T. J. Shah, C. E. Leik, and S. W. Walsh (2010)
Reproductive Sciences 17, 116-124
   Abstract »    PDF »
Vascular Endothelial Function Is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-Aged and Older Adults.
A. E. Walker, S. M. Seibert, A. J. Donato, G. L. Pierce, and D. R. Seals (2010)
Hypertension 55, 363-369
   Abstract »    Full Text »    PDF »
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.
V. Rudolph, T. K. Rudolph, F. J. Schopfer, G. Bonacci, S. R. Woodcock, M. P. Cole, P. R.S. Baker, R. Ramani, and B. A. Freeman (2010)
Cardiovasc Res 85, 155-166
   Abstract »    Full Text »    PDF »
Neutrophils Sequestered in the Liver Suppress the Proinflammatory Response of Kupffer Cells to Systemic Bacterial Infection.
M. Holub, C.-W. Cheng, S. Mott, P. Wintermeyer, N. van Rooijen, and S. H. Gregory (2009)
J. Immunol. 183, 3309-3316
   Abstract »    Full Text »    PDF »
Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease.
Z. Ali, P. Sarcia, T. H Mosley, V. Kondragunta, and I. J Kullo (2009)
Vascular Medicine 14, 215-220
   Abstract »    PDF »
Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling.
T. R. Nurkiewicz, D. W. Porter, A. F. Hubbs, S. Stone, B. T. Chen, D. G. Frazer, M. A. Boegehold, and V. Castranova (2009)
Toxicol. Sci. 110, 191-203
   Abstract »    Full Text »    PDF »
Myeloperoxidase, modified lipoproteins, and atherogenesis.
S. J. Nicholls and S. L. Hazen (2009)
J. Lipid Res. 50, S346-S351
   Abstract »    Full Text »    PDF »
Cytoglobin Is Expressed in the Vasculature and Regulates Cell Respiration and Proliferation via Nitric Oxide Dioxygenation.
K. E. Halligan, F. L. Jourd'heuil, and D. Jourd'heuil (2009)
J. Biol. Chem. 284, 8539-8547
   Abstract »    Full Text »    PDF »
Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists.
H.-R. Liu, L. Tao, E. Gao, Y. Qu, W. B. Lau, B. L. Lopez, T. A. Christopher, W. Koch, T.-L. Yue, and X.-L. Ma (2009)
Cardiovasc Res 81, 344-352
   Abstract »    Full Text »    PDF »
Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase.
V. Rudolph, T. K. Rudolph, F. J. Schopfer, G. Bonacci, D. Lau, K. Szocs, A. Klinke, T. Meinertz, B. A. Freeman, and S. Baldus (2008)
J. Pharmacol. Exp. Ther. 327, 324-331
   Abstract »    Full Text »    PDF »
Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation.
D. El Kebir, L. Jozsef, W. Pan, and J. G. Filep (2008)
Circ. Res. 103, 352-359
   Abstract »    Full Text »    PDF »
Increased Myeloperoxidase in the Placenta and Circulation of Women With Preeclampsia.
R. E. Gandley, J. Rohland, Y. Zhou, E. Shibata, G. F. Harger, A. Rajakumar, V. E. Kagan, N. Markovic, and C. A. Hubel (2008)
Hypertension 52, 387-393
   Abstract »    Full Text »    PDF »
Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.
V. Brovkovych, X.-P. Gao, E. Ong, S. Brovkovych, M.-L. Brennan, X. Su, S. L. Hazen, A. B. Malik, and R. A. Skidgel (2008)
Am J Physiol Lung Cell Mol Physiol 295, L96-L103
   Abstract »    Full Text »    PDF »
Oxidative Stress and Inflammation in Chronic Kidney Disease: Role of Intravenous Iron and Vitamin D.
A. B. Pai and T. A. Conner (2008)
Journal of Pharmacy Practice 21, 214-224
   Abstract »    PDF »
Blood pressure regulation: role for neutrophils?.
V. Rudolph, T. K. Rudolph, and B. A. Freeman (2008)
Blood 111, 4840
   Full Text »    PDF »
Myeloperoxidase, but not C-reactive protein, predicts cardiovascular risk in peripheral arterial disease.
G. Brevetti, V. Schiano, E. Laurenzano, G. Giugliano, M. Petretta, F. Scopacasa, and M. Chiariello (2008)
Eur. Heart J. 29, 224-230
   Abstract »    Full Text »    PDF »
The Interaction Between Coronary Endothelial Dysfunction, Local Oxidative Stress, and Endogenous Nitric Oxide in Humans.
S. Lavi, E. H. Yang, A. Prasad, V. Mathew, G. W. Barsness, C. S. Rihal, L. O. Lerman, and A. Lerman (2008)
Hypertension 51, 127-133
   Abstract »    Full Text »    PDF »
The Metabolism and Dechlorination of Chlorotyrosine in Vivo.
A. R. Mani, S. Ippolito, J. C. Moreno, T. J. Visser, and K. P. Moore (2007)
J. Biol. Chem. 282, 29114-29121
   Abstract »    Full Text »    PDF »
Association of Oxidative Stress, Insulin Resistance, and Diabetes Risk Phenotypes: The Framingham Offspring Study.
J. B. Meigs, M. G. Larson, C. S. Fox, J. F. Keaney Jr., R. S. Vasan, and E. J. Benjamin (2007)
Diabetes Care 30, 2529-2535
   Abstract »    Full Text »    PDF »
Neutrophil Interaction with the Hemostatic System Contributes to Liver Injury in Rats Cotreated with Lipopolysaccharide and Ranitidine.
X. Deng, J. P. Luyendyk, W. Zou, J. Lu, E. Malle, P. E. Ganey, and R. A. Roth (2007)
J. Pharmacol. Exp. Ther. 322, 852-861
   Abstract »    Full Text »    PDF »
Myeloperoxidase aids prognostication together with N-terminal pro-B-type natriuretic peptide in high-risk patients with acute ST elevation myocardial infarction.
S. Q Khan, D. Kelly, P. Quinn, J. E Davies, and L. L Ng (2007)
Heart 93, 826-831
   Abstract »    Full Text »    PDF »
Leukocyte membrane "expansion": a central mechanism for leukocyte extravasation.
S. Dewitt and M. Hallett (2007)
J. Leukoc. Biol. 81, 1160-1164
   Abstract »    Full Text »    PDF »
Biomarkers of Atherosclerotic Plaque Instability and Rupture.
W. Koenig and N. Khuseyinova (2007)
Arterioscler Thromb Vasc Biol 27, 15-26
   Abstract »    Full Text »    PDF »
Uncoupling of Endothelial Nitric Oxidase Synthase by Hypochlorous Acid: Role of NAD(P)H Oxidase-Derived Superoxide and Peroxynitrite.
J. Xu, Z. Xie, R. Reece, D. Pimental, and M.-H. Zou (2006)
Arterioscler Thromb Vasc Biol 26, 2688-2695
   Abstract »    Full Text »    PDF »
L-Arginine Chlorination Results in the Formation of a Nonselective Nitric-Oxide Synthase Inhibitor.
J. Yang, R. Ji, Y. Cheng, J.-Z. Sun, L. K. Jennings, and C. Zhang (2006)
J. Pharmacol. Exp. Ther. 318, 1044-1049
   Abstract »    Full Text »    PDF »
Anti-Neutrophil Cytoplasmic Antibodies and Effector CD4+ Cells Play Nonredundant Roles in Anti-Myeloperoxidase Crescentic Glomerulonephritis.
A.-J. Ruth, A. R. Kitching, R. Y.Q. Kwan, D. Odobasic, J. D.K. Ooi, J. R. Timoshanko, M. J. Hickey, and S. R. Holdsworth (2006)
J. Am. Soc. Nephrol. 17, 1940-1949
   Abstract »    Full Text »    PDF »
Heparins Increase Endothelial Nitric Oxide Bioavailability by Liberating Vessel-Immobilized Myeloperoxidase.
S. Baldus, V. Rudolph, M. Roiss, W. D. Ito, T. K. Rudolph, J. P. Eiserich, K. Sydow, D. Lau, K. Szocs, A. Klinke, et al. (2006)
Circulation 113, 1871-1878
   Abstract »    Full Text »    PDF »
Statin Treatment and Diabetes Affect Myeloperoxidase Activity in Maintenance Hemodialysis Patients.
P. Stenvinkel, E. Rodriguez-Ayala, Z. A. Massy, A. R. Qureshi, P. Barany, B. Fellstrom, O. Heimburger, B. Lindholm, and A. Alvestrand (2006)
Clin. J. Am. Soc. Nephrol. 1, 281-287
   Abstract »    Full Text »    PDF »
Myeloperoxidase Generates 5-Chlorouracil in Human Atherosclerotic Tissue: A POTENTIAL PATHWAY FOR SOMATIC MUTAGENESIS BY MACROPHAGES.
J. Takeshita, J. Byun, T. Q. Nhan, D. K. Pritchard, S. Pennathur, S. M. Schwartz, A. Chait, and J. W. Heinecke (2006)
J. Biol. Chem. 281, 3096-3104
   Abstract »    Full Text »    PDF »
P. R. S. Baker, Y. Lin, F. J. Schopfer, S. R. Woodcock, A. L. Groeger, C. Batthyany, S. Sweeney, M. H. Long, K. E. Iles, L. M. S. Baker, et al. (2005)
J. Biol. Chem. 280, 42464-42475
   Abstract »    Full Text »    PDF »
Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation Are Altered in Myeloperoxidase-Null Mice.
A. Haegens, A. van der Vliet, K. J. Butnor, N. Heintz, D. Taatjes, D. Hemenway, P. Vacek, B. A. Freeman, S. L. Hazen, M. L. Brennan, et al. (2005)
Cancer Res. 65, 9670-9677
   Abstract »    Full Text »    PDF »
Oxidative stress and nitric oxide deficiency in the kidney: a critical link to hypertension?.
C. S. Wilcox (2005)
Am J Physiol Regulatory Integrative Comp Physiol 289, R913-R935
   Abstract »    Full Text »    PDF »
Myeloperoxidase and Cardiovascular Disease.
S. J. Nicholls and S. L. Hazen (2005)
Arterioscler Thromb Vasc Biol 25, 1102-1111
   Abstract »    Full Text »    PDF »
F. J. Schopfer, P. R. S. Baker, G. Giles, P. Chumley, C. Batthyany, J. Crawford, R. P. Patel, N. Hogg, B. P. Branchaud, J. R. Lancaster Jr., et al. (2005)
J. Biol. Chem. 280, 19289-19297
   Abstract »    Full Text »    PDF »
Myeloperoxidase: friend and foe.
S. J. Klebanoff (2005)
J. Leukoc. Biol. 77, 598-625
   Abstract »    Full Text »    PDF »
P. K. Witting, B. J. Wu, M. Raftery, P. Southwell-Keely, and R. Stocker (2005)
J. Biol. Chem. 280, 15612-15618
   Abstract »    Full Text »    PDF »
Letter Regarding Article by Vita et al, "Serum Myeloperoxidase Levels Independently Predict Endothelial Dysfunction in Humans" * Response.
R. Walter, K. Schroecksnadel, D. Fuchs, J. A. Vita, J. F. Keaney Jr, N. Gokce, M.-L. Brennan, S. A. Mann, M. Goormastic, M. H. Shishehbor, et al. (2005)
Circulation 111, e167-e168
   Full Text »    PDF »
Myeloperoxidase Potentiates Nitric Oxide-mediated Nitrosation.
V. M. Lakshmi, W. M. Nauseef, and T. V. Zenser (2005)
J. Biol. Chem. 280, 1746-1753
   Abstract »    Full Text »    PDF »
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
D. Lau, H. Mollnau, J. P. Eiserich, B. A. Freeman, A. Daiber, U. M. Gehling, J. Brummer, V. Rudolph, T. Munzel, T. Heitzer, et al. (2005)
PNAS 102, 431-436
   Abstract »    Full Text »    PDF »
Cocoa polyphenols and inflammatory mediators.
H. Sies, T. Schewe, C. Heiss, and M. Kelm (2005)
Am J Clin Nutr 81, 304S-312S
   Abstract »    Full Text »    PDF »
2-Chlorohexadecanal Derived From Hypochlorite-Modified High-Density Lipoprotein-Associated Plasmalogen Is a Natural Inhibitor of Endothelial Nitric Oxide Biosynthesis.
G. Marsche, R. Heller, G. Fauler, A. Kovacevic, A. Nuszkowski, W. Graier, W. Sattler, and E. Malle (2004)
Arterioscler Thromb Vasc Biol 24, 2302-2306
   Abstract »    Full Text »    PDF »
Regioselective Nitration of Tryptophan by a Complex between Bacterial Nitric-oxide Synthase and Tryptophanyl-tRNA Synthetase.
M. R. Buddha, T. Tao, R. J. Parry, and B. R. Crane (2004)
J. Biol. Chem. 279, 49567-49570
   Abstract »    Full Text »    PDF »
Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose--Induced Endothelial Dysfunction Through Interaction With High-Glucose--Stimulated, Vascular Non--Leukocyte-Derived Reactive Oxygen Species.
C. Zhang, J. Yang, and L. K. Jennings (2004)
Diabetes 53, 2950-2959
   Abstract »    Full Text »    PDF »
Hypochlorous Acid Impairs Endothelium-Derived Nitric Oxide Bioactivity Through a Superoxide-Dependent Mechanism.
R. Stocker, A. Huang, E. Jeranian, J. Y. Hou, T. T. Wu, S. R. Thomas, and J. F. Keaney Jr (2004)
Arterioscler Thromb Vasc Biol 24, 2028-2033
   Abstract »    Full Text »    PDF »
Role of Oxidative Modifications in Atherosclerosis.
R. Stocker and J. F. Keaney Jr. (2004)
Physiol Rev 84, 1381-1478
   Abstract »    Full Text »    PDF »
Serum Myeloperoxidase Levels Independently Predict Endothelial Dysfunction in Humans.
J. A. Vita, M.-L. Brennan, N. Gokce, S. A. Mann, M. Goormastic, M. H. Shishehbor, M. S. Penn, J. F. Keaney Jr, and S. L. Hazen (2004)
Circulation 110, 1134-1139
   Abstract »    Full Text »    PDF »
Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation.
P. R. S. Baker, F. J. Schopfer, S. Sweeney, and B. A. Freeman (2004)
PNAS 101, 11577-11582
   Abstract »    Full Text »    PDF »
Role and importance of biochemical markers in clinical cardiology.
M. Panteghini (2004)
Eur. Heart J. 25, 1187-1196
   Abstract »    Full Text »    PDF »
Myeloperoxidase and Plaque Vulnerability.
S. L. Hazen (2004)
Arterioscler Thromb Vasc Biol 24, 1143-1146
   Full Text »    PDF »
Nitric oxide represses inhibitory {kappa}B kinase through S-nitrosylation.
N. L. Reynaert, K. Ckless, S. H. Korn, N. Vos, A. S. Guala, E. F. M. Wouters, A. van der Vliet, and Y. M. W. Janssen-Heininger (2004)
PNAS 101, 8945-8950
   Abstract »    Full Text »    PDF »
Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells.
C. Tiruppathi, T. Naqvi, Y. Wu, S. M. Vogel, R. D. Minshall, and A. B. Malik (2004)
PNAS 101, 7699-7704
   Abstract »    Full Text »    PDF »
Formation of Protein Tyrosine ortho-Semiquinone Radical and Nitrotyrosine from Cytochrome c-derived Tyrosyl Radical.
Y.-R. Chen, C.-L. Chen, W. Chen, J. L. Zweier, O. Augusto, R. Radi, and R. P. Mason (2004)
J. Biol. Chem. 279, 18054-18062
   Abstract »    Full Text »    PDF »
Do we kNOw how HSP90 and eNOS mediate lung injury in sickle cell disease?.
J. H. Schwartz, C. A. White, and B. A. Freeman (2004)
Am J Physiol Lung Cell Mol Physiol 286, L701-L704
   Full Text »    PDF »
The Role of Oxidative Stress-Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction.
G. A. Kaysen and J. P. Eiserich (2004)
J. Am. Soc. Nephrol. 15, 538-548
   Abstract »    Full Text »    PDF »
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations.
M. M. Tarpey, D. A. Wink, and M. B. Grisham (2004)
Am J Physiol Regulatory Integrative Comp Physiol 286, R431-R444
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-activated Receptor {gamma} Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism.
A. P. Kumar, F. J. Piedrafita, and W. F. Reynolds (2004)
J. Biol. Chem. 279, 8300-8315
   Abstract »    Full Text »    PDF »
Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition.
S. Galijasevic, G. M. Saed, M. P. Diamond, and H. M. Abu-Soud (2003)
PNAS 100, 14766-14771
   Abstract »    Full Text »    PDF »
Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases.
C. Zhang, J. Yang, J. D. Jacobs, and L. K. Jennings (2003)
Am J Physiol Heart Circ Physiol 285, H2563-H2572
   Abstract »    Full Text »    PDF »
Reactive Oxygen Species in the Vasculature: Molecular and Cellular Mechanisms.
Y. Taniyama and K. K. Griendling (2003)
Hypertension 42, 1075-1081
   Abstract »    Full Text »    PDF »
Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies.
K. K. Griendling and G. A. FitzGerald (2003)
Circulation 108, 2034-2040
   Full Text »    PDF »
Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1.
S. Mutze, U. Hebling, W. Stremmel, J. Wang, J. Arnhold, K. Pantopoulos, and S. Mueller (2003)
J. Biol. Chem. 278, 40542-40549
   Abstract »    Full Text »    PDF »
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes.
S. Baldus, C. Heeschen, T. Meinertz, A. M. Zeiher, J. P. Eiserich, T. Munzel, M. L. Simoons, C. W. Hamm, and on behalf of the CAPTURE Investigators (2003)
Circulation 108, 1440-1445
   Abstract »    Full Text »    PDF »
Coronary Artery Disease in End-Stage Renal Disease: No Longer a Simple Plumbing Problem.
P. Stenvinkel, R. Pecoits-Filho, and B. Lindholm (2003)
J. Am. Soc. Nephrol. 14, 1927-1939
   Full Text »    PDF »
The Pickering Lecture British Hypertension Society, 10th September 2002: Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
D. G Harrison, Hua Cai, U. Landmesser, and K. K Griendling (2003)
Journal of Renin-Angiotensin-Aldosterone System 4, 51-61
   Abstract »    PDF »
Preference Toward a T-Helper Type 1 Response in Patients With Coronary Spastic Angina.
H. Soejima, A. Irie, S. Miyamoto, I. Kajiwara, S. Kojima, J. Hokamaki, T. Sakamoto, T. Tanaka, M. Yoshimura, Y. Nishimura, et al. (2003)
Circulation 107, 2196-2200
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882