Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 297 (5579): 259-263

Copyright © 2002 by the American Association for the Advancement of Science

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Seong-Woon Yu,1* Hongmin Wang,1* Marc F. Poitras,1 Carmen Coombs,1 William J. Bowers,5 Howard J. Federoff,5 Guy G. Poirier,6 Ted M. Dawson,124 Valina L. Dawson1234dagger

Poly(ADP-ribose) polymerase-1 (PARP-1) protects the genome by functioning in the DNA damage surveillance network. PARP-1 is also a mediator of cell death after ischemia-reperfusion injury, glutamate excitotoxicity, and various inflammatory processes. We show that PARP-1 activation is required for translocation of apoptosis-inducing factor (AIF) from the mitochondria to the nucleus and that AIF is necessary for PARP-1-dependent cell death. N-methyl-N'-nitro-N-nitrosoguanidine, H2O2, and N-methyl-D-aspartate induce AIF translocation and cell death, which is prevented by PARP inhibitors or genetic knockout of PARP-1, but is caspase independent. Microinjection of an antibody to AIF protects against PARP-1-dependent cytotoxicity. These data support a model in which PARP-1 activation signals AIF release from mitochondria, resulting in a caspase-independent pathway of programmed cell death.

1 Departments of Neurology,
2 Neuroscience, and
3 Physiology; and
4 the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
5 Department of Neurology, Center for Aging and Developmental Biology, University of Rochester, NY 14642, USA.
6 Health and Environment Unit, Laval University Medical Research Center, CHUQ, Ste-Foy, Quebec G1V 4G2, Canada.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: vdawson{at}jhmi.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.
D. Fu, J. J. Jordan, and L. D. Samson (2013)
Genes & Dev. 27, 1089-1100
   Abstract »    Full Text »    PDF »
ROS-Mediated PARP Activity Undermines Mitochondrial Function After Permeability Transition Pore Opening During Myocardial Ischemia-Reperfusion.
J. M. Schriewer, C. B. Peek, J. Bass, and P. T. Schumacker (2013)
JAHA 2, e000159
   Abstract »    Full Text »    PDF »
Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, in Human Cancer Cells: METABOLIC BASIS AND POTENTIAL CLINICAL IMPLICATIONS.
B. Tan, D. A. Young, Z.-H. Lu, T. Wang, T. I. Meier, R. L. Shepard, K. Roth, Y. Zhai, K. Huss, M.-S. Kuo, et al. (2013)
J. Biol. Chem. 288, 3500-3511
   Abstract »    Full Text »    PDF »
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development.
W. Li, Y. Xiong, C. Shang, K. Y. Twu, C. T. Hang, J. Yang, P. Han, C.-Y. Lin, C.-J. Lin, F.-C. Tsai, et al. (2013)
PNAS 110, 1738-1743
   Abstract »    Full Text »    PDF »
Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes.
J. Aurelius, A. Martner, R. E. Riise, A. I. Romero, L. Palmqvist, M. Brune, K. Hellstrand, and F. B. Thoren (2013)
J. Leukoc. Biol. 93, 155-160
   Abstract »    Full Text »    PDF »
Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration.
H. Zhang, Y.-w. Zhang, Y. Chen, X. Huang, F. Zhou, W. Wang, B. Xian, X. Zhang, E. Masliah, Q. Chen, et al. (2012)
J. Neurosci. 32, 15565-15576
   Abstract »    Full Text »    PDF »
Regulation of Cell Survival and Death by Pyridine Nucleotides.
S.-i. Oka, C.-P. Hsu, and J. Sadoshima (2012)
Circ. Res. 111, 611-627
   Abstract »    Full Text »    PDF »
PARPs and the DNA damage response.
F. G. Sousa, R. Matuo, D. G. Soares, A. E. Escargueil, J. A. P. Henriques, A. K. Larsen, and J. Saffi (2012)
Carcinogenesis 33, 1433-1440
   Abstract »    Full Text »    PDF »
Programmed Cell Death in Parkinson's Disease.
K. Venderova and D. S. Park (2012)
Cold Spring Harb Perspect Med 2, a009365
   Abstract »    Full Text »    PDF »
A Dual Role for Poly(ADP-Ribose) Polymerase-1 * During Caspase-Dependent Apoptosis.
F. Zhang, S. S. Lau, and T. J. Monks (2012)
Toxicol. Sci. 128, 103-114
   Abstract »    Full Text »    PDF »
Mitochondrial P5, a member of protein disulphide isomerase family, suppresses oxidative stress-induced cell death.
Y. Shitara, Y. Tonohora, T. Goto, Y. Yamada, T. Miki, H. Makino, M. Miwa, and T. Komiya (2012)
J. Biochem. 152, 73-85
   Abstract »    Full Text »    PDF »
Mapping Protein Surface Accessibility via an Electron Transfer Dissociation Selectively Cleavable Hydrazone Probe.
L. Vasicek, J. P. O'Brien, K. S. Browning, Z. Tao, H.-W. Liu, and J. S. Brodbelt (2012)
Mol. Cell. Proteomics 11, O111.015826
   Abstract »    Full Text »    PDF »
Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.
H. Jo, S. Mondal, D. Tan, E. Nagata, S. Takizawa, A. K. Sharma, Q. Hou, K. Shanmugasundaram, A. Prasad, J. K. Tung, et al. (2012)
PNAS 109, 10581-10586
   Abstract »    Full Text »    PDF »
Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91phox expression and the PARP-1/PAR pathway of apoptosis.
J. Aurelius, F. B. Thoren, A. A. Akhiani, M. Brune, L. Palmqvist, M. Hansson, K. Hellstrand, and A. Martner (2012)
Blood 119, 5832-5837
   Abstract »    Full Text »    PDF »
The Activation of DNA Damage Detection and Repair Responses in Cleavage-Stage Rat Embryos by a Damaged Paternal Genome.
L. Grenier, B. Robaire, and B. F. Hales (2012)
Toxicol. Sci. 127, 555-566
   Abstract »    Full Text »    PDF »
ADP-ribosylhydrolase 3 (ARH3), Not Poly(ADP-ribose) Glycohydrolase (PARG) Isoforms, Is Responsible for Degradation of Mitochondrial Matrix-associated Poly(ADP-ribose).
M. Niere, M. Mashimo, L. Agledal, C. Dolle, A. Kasamatsu, J. Kato, J. Moss, and M. Ziegler (2012)
J. Biol. Chem. 287, 16088-16102
   Abstract »    Full Text »    PDF »
Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria.
D. Wang, J. Liang, Y. Zhang, B. Gui, F. Wang, X. Yi, L. Sun, Z. Yao, and Y. Shang (2012)
J. Biol. Chem. 287, 12612-12621
   Abstract »    Full Text »    PDF »
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.
X. Luo and W. L. Kraus (2012)
Genes & Dev. 26, 417-432
   Abstract »    Full Text »    PDF »
Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.
S. J. Smith, A. Long, J. H. Barrow, D. C. Macarthur, B. Coyle, R. G. Grundy, and on behalf of the Children's Cancer and Leukaemia G (2011)
Neuro Oncology 13, 1171-1177
   Abstract »    Full Text »    PDF »
Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction.
H. Chang, S. Chen, S. Chien, S. Kuo, H. Tsai, and D. Chen (2011)
Human and Experimental Toxicology 30, 1657-1665
   Abstract »    PDF »
Simultaneous Cell Death and Upregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Early Postnatal Mouse Retina.
D. Martin-Oliva, R. M. Ferrer-Martin, A. M. Santos, M. C. Carrasco, A. Sierra, J. L. Marin-Teva, R. Calvente, J. Navascues, and M. A. Cuadros (2011)
Invest. Ophthalmol. Vis. Sci. 52, 7445-7454
   Abstract »    Full Text »    PDF »
Modulatory profiling identifies mechanisms of small molecule-induced cell death.
A. J. Wolpaw, K. Shimada, R. Skouta, M. E. Welsch, U. D. Akavia, D. Pe'er, F. Shaik, J. C. Bulinski, and B. R. Stockwell (2011)
PNAS 108, E771-E780
   Abstract »    Full Text »    PDF »
Allyl Isothiocyanate Arrests Cancer Cells in Mitosis, and Mitotic Arrest in Turn Leads to Apoptosis via Bcl-2 Protein Phosphorylation.
F. Geng, L. Tang, Y. Li, L. Yang, K.-S. Choi, A. L. Kazim, and Y. Zhang (2011)
J. Biol. Chem. 286, 32259-32267
   Abstract »    Full Text »    PDF »
Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis.
M. Tomasetti, M. Amati, L. Nocchi, F. Saccucci, E. Strafella, S. Staffolani, L. M. Tarquini, D. Carbonari, R. Alleva, B. Borghi, et al. (2011)
Mutagenesis 26, 585-591
   Abstract »    Full Text »    PDF »
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
H. C. Kang, Y.-I. Lee, J.-H. Shin, S. A. Andrabi, Z. Chi, J.-P. Gagne, Y. Lee, H. S. Ko, B. D. Lee, G. G. Poirier, et al. (2011)
PNAS 108, 14103-14108
   Abstract »    Full Text »    PDF »
DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.
J. E. P. Loughery, P. D. Dunne, K. M. O'Neill, R. R. Meehan, J. R. McDaid, and C. P. Walsh (2011)
Hum. Mol. Genet. 20, 3241-3255
   Abstract »    Full Text »    PDF »
Dipeptidyl Peptidases as Survival Factors in Ewing Sarcoma Family of Tumors: IMPLICATIONS FOR TUMOR BIOLOGY AND THERAPY.
C. Lu, J. U. Tilan, L. Everhart, M. Czarnecka, S. J. Soldin, D. R. Mendu, D. Jeha, J. Hanafy, C. K. Lee, J. Sun, et al. (2011)
J. Biol. Chem. 286, 27494-27505
   Abstract »    Full Text »    PDF »
Helicobacter pylori VacA Induces Programmed Necrosis in Gastric Epithelial Cells.
J. N. Radin, C. Gonzalez-Rivera, S. E. Ivie, M. S. McClain, and T. L. Cover (2011)
Infect. Immun. 79, 2535-2543
   Abstract »    Full Text »    PDF »
Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells.
Y. Zhuang and W. K. Miskimins (2011)
Mol. Cancer Res. 9, 603-615
   Abstract »    Full Text »    PDF »
Programmed Necrosis, Not Apoptosis, in the Heart.
G. Kung, K. Konstantinidis, and R. N. Kitsis (2011)
Circ. Res. 108, 1017-1036
   Abstract »    Full Text »    PDF »
Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos).
Y. Wang, N. S. Kim, J.-F. Haince, H. C. Kang, K. K. David, S. A. Andrabi, G. G. Poirier, V. L. Dawson, and T. M. Dawson (2011)
Science Signaling 4, ra20
   Abstract »    Full Text »    PDF »
Sex Differences in the Response to Poly(ADP-ribose) Polymerase-1 Deletion and Caspase Inhibition After Stroke.
F. Liu, J. Lang, J. Li, S. E. Benashski, M. Siegel, Y. Xu, and L. D. McCullough (2011)
Stroke 42, 1090-1096
   Abstract »    Full Text »    PDF »
Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair.
E. M. Goellner, B. Grimme, A. R. Brown, Y.-C. Lin, X.-H. Wang, K. F. Sugrue, L. Mitchell, R. N. Trivedi, J.-b. Tang, and R. W. Sobol (2011)
Cancer Res. 71, 2308-2317
   Abstract »    Full Text »    PDF »
Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages.
E. Aflaki, B. Radovic, P. G. Chandak, D. Kolb, T. Eisenberg, J. Ring, I. Fertschai, A. Uellen, H. Wolinski, S.-D. Kohlwein, et al. (2011)
J. Biol. Chem. 286, 7418-7428
   Abstract »    Full Text »    PDF »
Chromatin Remodeling in Cardiovascular Development and Physiology.
P. Han, C. T. Hang, J. Yang, and C.-P. Chang (2011)
Circ. Res. 108, 378-396
   Abstract »    Full Text »    PDF »
hPuf-A/KIAA0020 Modulates PARP-1 Cleavage upon Genotoxic Stress.
H.-Y. Chang, C.-C. Fan, P.-C. Chu, B.-E. Hong, H. J. Lee, and M.-S. Chang (2011)
Cancer Res. 71, 1126-1134
   Abstract »    Full Text »    PDF »
Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3-Phosphatidylinositol 3-Kinase-Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region.
Z. Zhong, Y. Wang, H. Guo, A. Sagare, J. A. Fernandez, R. D. Bell, T. M. Barrett, J. H. Griffin, R. S. Freeman, and B. V. Zlokovic (2010)
J. Neurosci. 30, 15521-15534
   Abstract »    Full Text »    PDF »
Interleukin-23 acts as antitumor agent on childhood B-acute lymphoblastic leukemia cells.
C. Cocco, S. Canale, C. Frasson, E. Di Carlo, E. Ognio, D. Ribatti, I. Prigione, G. Basso, and I. Airoldi (2010)
Blood 116, 3887-3898
   Abstract »    Full Text »    PDF »
Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA.
S. Bae, P. M. Siu, S. Choudhury, Q. Ke, J. H. Choi, Y. Y. Koh, and P. M. Kang (2010)
Am J Physiol Heart Circ Physiol 299, H1374-H1381
   Abstract »    Full Text »    PDF »
Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway.
R. Handrick, T. Ontikatze, K.-D. Bauer, F. Freier, A. Rubel, J. Durig, C. Belka, and V. Jendrossek (2010)
Mol. Cancer Ther. 9, 2497-2510
   Abstract »    Full Text »    PDF »
Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia.
Z. Xu, J. Zhang, K. K. David, Z.-J. Yang, X. Li, T. M. Dawson, V. L. Dawson, and R. C. Koehler (2010)
Am J Physiol Regulatory Integrative Comp Physiol 299, R215-R221
   Abstract »    Full Text »    PDF »
Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.
P. S. Koka, D. Mondal, M. Schultz, A. B. Abdel-Mageed, and K. C. Agrawal (2010)
Exp Biol Med 235, 751-760
   Abstract »    Full Text »    PDF »
Proteome profiling of early seed development in Cunninghamia lanceolata (Lamb.) Hook.
J. Shi, Y. Zhen, and R.-H. Zheng (2010)
J. Exp. Bot. 61, 2367-2381
   Abstract »    Full Text »    PDF »
Poly(ADP-ribose) Polymerase (PARP)-1-independent Apoptosis-inducing Factor (AIF) Release and Cell Death Are Induced by Eleostearic Acid and Blocked by {alpha}-Tocopherol and MEK Inhibition.
K. Kondo, S. Obitsu, S. Ohta, K. Matsunami, H. Otsuka, and R. Teshima (2010)
J. Biol. Chem. 285, 13079-13091
   Abstract »    Full Text »    PDF »
Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death.
S. Veto, P. Acs, J. Bauer, H. Lassmann, Z. Berente, G. Setalo Jr, G. Borgulya, B. Sumegi, S. Komoly, F. Gallyas Jr, et al. (2010)
Brain 133, 822-834
   Abstract »    Full Text »    PDF »
NAD+ Depletion Is Necessary and Sufficient forPoly(ADP-Ribose) Polymerase-1-Mediated Neuronal Death.
C. C. Alano, P. Garnier, W. Ying, Y. Higashi, T. M. Kauppinen, and R. A. Swanson (2010)
J. Neurosci. 30, 2967-2978
   Abstract »    Full Text »    PDF »
Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells.
M. Okuya, H. Kurosawa, J. Kikuchi, Y. Furukawa, H. Matsui, D. Aki, T. Matsunaga, T. Inukai, H. Goto, R. A. Altura, et al. (2010)
J. Biol. Chem. 285, 1850-1860
   Abstract »    Full Text »    PDF »
Bioenergetic Metabolites Regulate Base Excision Repair-Dependent Cell Death in Response to DNA Damage.
J.-b. Tang, E. M. Goellner, X.-h. Wang, R. N. Trivedi, C. M. St Croix, E. Jelezcova, D. Svilar, A. R. Brown, and R. W. Sobol (2010)
Mol. Cancer Res. 8, 67-79
   Abstract »    Full Text »    PDF »
Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats.
S. Choudhury, S. Bae, S. R. Kumar, Q. Ke, B. Yalamarti, J. H. Choi, L. A. Kirshenbaum, and P. M. Kang (2010)
Cardiovasc Res 85, 28-37
   Abstract »    Full Text »    PDF »
Global Analysis of Transcriptional Regulation by Poly(ADP-ribose) Polymerase-1 and Poly(ADP-ribose) Glycohydrolase in MCF-7 Human Breast Cancer Cells.
K. M. Frizzell, M. J. Gamble, J. G. Berrocal, T. Zhang, R. Krishnakumar, Y. Cen, A. A. Sauve, and W. L. Kraus (2009)
J. Biol. Chem. 284, 33926-33938
   Abstract »    Full Text »    PDF »
Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity.
M. N. Rossi, M. Carbone, C. Mostocotto, C. Mancone, M. Tripodi, R. Maione, and P. Amati (2009)
J. Biol. Chem. 284, 31616-31624
   Abstract »    Full Text »    PDF »
Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells.
K. Erdelyi, P. Bai, I. Kovacs, E. Szabo, G. Mocsar, A. Kakuk, C. Szabo, P. Gergely, and L. Virag (2009)
FASEB J 23, 3553-3563
   Abstract »    Full Text »    PDF »
PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis.
V. Selvaraj, M. M. Soundarapandian, O. Chechneva, A. J. Williams, M. K. Sidorov, A. M. Soulika, D. E. Pleasure, and W. Deng (2009)
J. Biol. Chem. 284, 26070-26084
   Abstract »    Full Text »    PDF »
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.
P. Zhu, D. Martinvalet, D. Chowdhury, D. Zhang, A. Schlesinger, and J. Lieberman (2009)
Blood 114, 1205-1216
   Abstract »    Full Text »    PDF »
Identification of Cellular Proteome Modifications in Response to West Nile Virus Infection.
B. Pastorino, E. Boucomont-Chapeaublanc, C. N. Peyrefitte, M. Belghazi, T. Fusai, C. Rogier, H. J. Tolou, and L. Almeras (2009)
Mol. Cell. Proteomics 8, 1623-1637
   Abstract »    Full Text »    PDF »
Poly(ADP-ribose) Catabolism Triggers AMP-dependent Mitochondrial Energy Failure.
L. Formentini, A. Macchiarulo, G. Cipriani, E. Camaioni, E. Rapizzi, R. Pellicciari, F. Moroni, and A. Chiarugi (2009)
J. Biol. Chem. 284, 17668-17676
   Abstract »    Full Text »    PDF »
Radiation-induced mitotic catastrophe in PARG-deficient cells.
J.-C. Ame, E. Fouquerel, L. R. Gauthier, D. Biard, F. D. Boussin, F. Dantzer, G. de Murcia, and V. Schreiber (2009)
J. Cell Sci. 122, 1990-2002
   Abstract »    Full Text »    PDF »
Sex Differences in Caspase Activation After Stroke.
F. Liu, Z. Li, J. Li, C. Siegel, R. Yuan, and L. D. McCullough (2009)
Stroke 40, 1842-1848
   Abstract »    Full Text »    PDF »
Poly(ADP-ribose) polymerase suppression protects rheumatoid synovial fibroblasts from Fas-induced apoptosis.
S. Garcia, A. Mera, J. J. Gomez-Reino, and C. Conde (2009)
Rheumatology 48, 483-489
   Abstract »    Full Text »    PDF »
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.
S. H. Cho, S. Goenka, T. Henttinen, P. Gudapati, A. Reinikainen, C. M. Eischen, R. Lahesmaa, and M. Boothby (2009)
Blood 113, 2416-2425
   Abstract »    Full Text »    PDF »
Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways.
D. Barlos, E. A. Deitch, A. C. Watkins, F. J. Caputo, Q. Lu, B. Abungu, I. Colorado, D.-Z. Xu, and R. Feinman (2009)
Am J Physiol Lung Cell Mol Physiol 296, L404-L417
   Abstract »    Full Text »    PDF »
Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects.
O Arroyo-Helguera, E Rojas, G Delgado, and C Aceves (2008)
Endocr. Relat. Cancer 15, 1003-1011
   Abstract »    Full Text »    PDF »
Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors.
T. Eltze, R. Boer, T. Wagner, S. Weinbrenner, M. C. McDonald, C. Thiemermann, A. Burkle, and T. Klein (2008)
Mol. Pharmacol. 74, 1587-1598
   Abstract »    Full Text »    PDF »
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.
H.-J. Chiu, D. A. Fischman, and U. Hammerling (2008)
FASEB J 22, 3878-3887
   Abstract »    Full Text »    PDF »
SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70.
N. R. Sundaresan, S. A. Samant, V. B. Pillai, S. B. Rajamohan, and M. P. Gupta (2008)
Mol. Cell. Biol. 28, 6384-6401
   Abstract »    Full Text »    PDF »
Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress.
A. Rongvaux, M. Galli, S. Denanglaire, F. Van Gool, P. L. Dreze, C. Szpirer, F. Bureau, F. Andris, and O. Leo (2008)
J. Immunol. 181, 4685-4695
   Abstract »    Full Text »    PDF »
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain.
J. An, C. Zhang, R. Polavarapu, X. Zhang, X. Zhang, and M. Yepes (2008)
Blood 112, 2787-2794
   Abstract »    Full Text »    PDF »
Inhibitors of Cytochrome c Release with Therapeutic Potential for Huntington's Disease.
X. Wang, S. Zhu, Z. Pei, M. Drozda, I. G. Stavrovskaya, S. J. Del Signore, K. Cormier, E. M. Shimony, H. Wang, R. J. Ferrante, et al. (2008)
J. Neurosci. 28, 9473-9485
   Abstract »    Full Text »    PDF »
Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death: Role of Enhanced DNA Repair.
S. Wang, Z. Xing, P. S. Vosler, H. Yin, W. Li, F. Zhang, A. P. Signore, R. A. Stetler, Y. Gao, and J. Chen (2008)
Stroke 39, 2587-2595
   Abstract »    Full Text »    PDF »
CCCTC-binding Factor Activates PARP-1 Affecting DNA Methylation Machinery.
T. Guastafierro, B. Cecchinelli, M. Zampieri, A. Reale, G. Riggio, O. Sthandier, G. Zupi, L. Calabrese, and P. Caiafa (2008)
J. Biol. Chem. 283, 21873-21880
   Abstract »    Full Text »    PDF »
Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner.
C.-H. Tsao, H.-L. Su, Y.-L. Lin, H.-P. Yu, S.-M. Kuo, C.-I Shen, C.-W. Chen, and C.-L. Liao (2008)
J. Gen. Virol. 89, 1930-1941
   Abstract »    Full Text »    PDF »
Bobel-24 and Derivatives Induce Caspase-Independent Death in Pancreatic Cancer Regardless of Apoptotic Resistance.
M. Parreno, I. Casanova, M. V. Cespedes, J. P. Vaque, M. A. Pavon, J. Leon, and R. Mangues (2008)
Cancer Res. 68, 6313-6323
   Abstract »    Full Text »    PDF »
HGF Increases Cisplatin Resistance via Down-Regulation of AIF in Lung Cancer Cells.
J.-T. Chen, C.-Y. Huang, Y.-Y. Chiang, W.-H. Chen, S.-H. Chiou, C.-Y. Chen, and K.-C. Chow (2008)
38, 559-565
   Abstract »    Full Text »    PDF »
Interaction of Heterogeneous Nuclear Ribonucleoprotein C1/C2 with a Novel cis-Regulatory Element within p53 mRNA as a Response to Cytostatic Drug Treatment.
K. J. Christian, M. A. Lang, and F. Raffalli-Mathieu (2008)
Mol. Pharmacol. 73, 1558-1567
   Abstract »    Full Text »    PDF »
Glioma Regression In vitro and In vivo by a Suicide Combined Treatment.
V. Garcia-Escudero, R. Gargini, and M. Izquierdo (2008)
Mol. Cancer Res. 6, 407-417
   Abstract »    Full Text »    PDF »
The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
I. Petit, M. A. Karajannis, L. Vincent, L. Young, J. Butler, A. T. Hooper, K. Shido, H. Steller, D. J. Chaplin, E. Feldman, et al. (2008)
Blood 111, 1951-1961
   Abstract »    Full Text »    PDF »
Gender-Related Differences in Apoptotic Pathways After Neonatal Cerebral Ischemia.
S. Renolleau, S. Fau, and C. Charriaut-Marlangue (2008)
Neuroscientist 14, 46-52
   Abstract »    PDF »
Advances in Neuronal Cell Death 2007.
M. M. Harraz, T. M. Dawson, and V. L. Dawson (2008)
Stroke 39, 286-288
   Full Text »    PDF »
Functional Localization of Two Poly(ADP-Ribose)-Degrading Enzymes to the Mitochondrial Matrix.
M. Niere, S. Kernstock, F. Koch-Nolte, and M. Ziegler (2008)
Mol. Cell. Biol. 28, 814-824
   Abstract »    Full Text »    PDF »
Apoptosis-Inducing Factor Is a Target for Ubiquitination through Interaction with XIAP.
J. C. Wilkinson, A. S. Wilkinson, S. Galban, R. A. Csomos, and C. S. Duckett (2008)
Mol. Cell. Biol. 28, 237-247
   Abstract »    Full Text »    PDF »
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length.
J. Fahrer, R. Kranaster, M. Altmeyer, A. Marx, and A. Burkle (2007)
Nucleic Acids Res. 35, e143
   Abstract »    Full Text »    PDF »
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity.
Y. Duan, R. A. Gross, and S.-S. Sheu (2007)
J. Physiol. 585, 741-758
   Abstract »    Full Text »    PDF »
Poly(ADP-ribosyl)ation in mammalian ageing.
S. Beneke and A. Burkle (2007)
Nucleic Acids Res. 35, 7456-7465
   Abstract »    Full Text »    PDF »
Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats.
I. G. Obrosova, V. R. Drel, C. L. Oltman, N. Mashtalir, J. Tibrewala, J. T. Groves, and M. A. Yorek (2007)
Am J Physiol Endocrinol Metab 293, E1645-E1655
   Abstract »    Full Text »    PDF »
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.
S. Andrabi, O. V. Gjoerup, J. A. Kean, T. M. Roberts, and B. Schaffhausen (2007)
PNAS 104, 19011-19016
   Abstract »    Full Text »    PDF »
Excessive Activation of Poly(ADP-Ribose) Polymerase Contributes to Inherited Photoreceptor Degeneration in the Retinal Degeneration 1 Mouse.
F. Paquet-Durand, J. Silva, T. Talukdar, L. E. Johnson, S. Azadi, T. van Veen, M. Ueffing, S. M. Hauck, and P. A. R. Ekstrom (2007)
J. Neurosci. 27, 10311-10319
   Abstract »    Full Text »    PDF »
Silencing of poly(ADP-ribose) polymerase in plants alters abiotic stress signal transduction.
S. Vanderauwera, M. De Block, N. Van de Steene, B. van de Cotte, M. Metzlaff, and F. Van Breusegem (2007)
PNAS 104, 15150-15155
   Abstract »    Full Text »    PDF »
Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury.
G. Cao, J. Xing, X. Xiao, A. K. F. Liou, Y. Gao, X.-M. Yin, R. S. B. Clark, S. H. Graham, and J. Chen (2007)
J. Neurosci. 27, 9278-9293
   Abstract »    Full Text »    PDF »
Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells.
H. Zhang, T. Mizumachi, J. Carcel-Trullols, L. Li, A. Naito, H. J. Spencer, P. M. Spring, B. R. Smoller, A. J. Watson, G. P. Margison, et al. (2007)
Carcinogenesis 28, 1629-1637
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882