Theresa T. Lu, Jason G. Cyster^*

The mechanisms that control localization of marginal zone (MZ) B cells are poorly understood. Here we show that MZ B cells express elevated levels of the integrins LFA-1 (L2) and 41 and that they bind to the ligands ICAM-1 and VCAM-1. These ligands are expressed within the MZ in a lymphotoxin-dependent manner. Combined inhibition of LFA-1 and 41 causes a rapid and selective release of B cells from the MZ. Furthermore, lipopolysaccharide-triggered MZ B cell relocalization involves down-regulation of integrin-mediated adhesion. These studies identify key requirements for MZ B cell localization and establish a role for integrins in peripheral lymphoid tissue compartmentalization.

Howard Hughes Medical Institute, Department of Microbiology and Immunology, and Division of Pediatric Immunology and Rheumatology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
^*   To whom correspondence should be addressed. E-mail: cyster{at}itsa.ucsf.edu

Natalizumab treatment decreases serum IgM and IgG levels in multiple sclerosis patients.

R. C. Selter, V. Biberacher, V. Grummel, D. Buck, C. Eienbroker, W. H. Oertel, A. Berthele, B. Tackenberg, and B. Hemmer (2013)
Multiple Sclerosis Journal
 |  Abstract »  |  Full Text »  |  PDF »

Low-affinity B cells transport viral particles from the lung to the spleen to initiate antibody responses.

J. Bessa, F. Zabel, A. Link, A. Jegerlehner, H. J. Hinton, N. Schmitz, M. Bauer, T. M. Kundig, P. Saudan, and M. F. Bachmann (2012)
PNAS 109, 20566-20571
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain.

M. W. Ferenczy, L. J. Marshall, C. D. S. Nelson, W. J. Atwood, A. Nath, K. Khalili, and E. O. Major (2012)
Clin. Microbiol. Rev. 25, 471-506
 |  Abstract »  |  Full Text »  |  PDF »

Marginal Zone B Cells Regulate Antigen-Specific T Cell Responses during Infection.

R. Bankoti, K. Gupta, A. Levchenko, and S. Stager (2012)
J. Immunol. 188, 3961-3971
 |  Abstract »  |  Full Text »  |  PDF »

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

M. Recher, S. O. Burns, M. A. de la Fuente, S. Volpi, C. Dahlberg, J. E. Walter, K. Moffitt, D. Mathew, N. Honke, P. A. Lang, et al. (2012)
Blood 119, 2819-2828
 |  Abstract »  |  Full Text »  |  PDF »

Innate Response Activator B Cells Protect Against Microbial Sepsis.

P. J. Rauch, A. Chudnovskiy, C. S. Robbins, G. F. Weber, M. Etzrodt, I. Hilgendorf, E. Tiglao, J.-L. Figueiredo, Y. Iwamoto, I. Theurl, et al. (2012)
Science 335, 597-601
 |  Abstract »  |  Full Text »  |  PDF »

Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions.

C. S. Robbins, A. Chudnovskiy, P. J. Rauch, J.-L. Figueiredo, Y. Iwamoto, R. Gorbatov, M. Etzrodt, G. F. Weber, T. Ueno, N. van Rooijen, et al. (2012)
Circulation 125, 364-374
 |  Abstract »  |  Full Text »  |  PDF »

The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12.

H. Wang, N. Beaty, S. Chen, C.-F. Qi, M. Masiuk, D.-M. Shin, and H. C. Morse III (2012)
Blood 119, 465-468
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid Receptor 2 Is Critical for the Homing and Retention of Marginal Zone B Lineage Cells and for Efficient T-Independent Immune Responses.

S. Basu, A. Ray, and B. N. Dittel (2011)
J. Immunol. 187, 5720-5732
 |  Abstract »  |  Full Text »  |  PDF »

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers.

X. Wang, B. Cho, K. Suzuki, Y. Xu, J. A. Green, J. An, and J. G. Cyster (2011)
J. Exp. Med. 208, 2497-2510
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.

J. R. Muppidi, T. I. Arnon, Y. Bronevetsky, N. Veerapen, M. Tanaka, G. S. Besra, and J. G. Cyster (2011)
J. Exp. Med. 208, 1941-1948
 |  Abstract »  |  Full Text »  |  PDF »

The Actin-Bundling Protein L-Plastin Is Essential for Marginal Zone B Cell Development.

E. M. Todd, L. E. Deady, and S. C. Morley (2011)
J. Immunol. 187, 3015-3025
 |  Abstract »  |  Full Text »  |  PDF »

B cells enhance early innate immune responses during bacterial sepsis.

K. M. Kelly-Scumpia, P. O. Scumpia, J. S. Weinstein, M. J. Delano, A. G. Cuenca, D. C. Nacionales, J. L. Wynn, P. Y. Lee, Y. Kumagai, P. A. Efron, et al. (2011)
J. Exp. Med. 208, 1673-1682
 |  Abstract »  |  Full Text »  |  PDF »

Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice.

C. A. H. Hansell, C. Schiering, R. Kinstrie, L. Ford, Y. Bordon, I. B. McInnes, C. S. Goodyear, and R. J. B. Nibbs (2011)
Blood 117, 5413-5424
 |  Abstract »  |  Full Text »  |  PDF »

Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3).

G. Turchinovich, T. T. Vu, F. Frommer, J. Kranich, S. Schmid, M. Alles, J.-B. Loubert, J.-P. Goulet, U. Zimber-Strobl, P. Schneider, et al. (2011)
Blood 117, 3780-3792
 |  Abstract »  |  Full Text »  |  PDF »

Kruppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression.

G. T. Hart, X. Wang, K. A. Hogquist, and S. C. Jameson (2011)
PNAS 108, 716-721
 |  Abstract »  |  Full Text »  |  PDF »

Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen.

E. Manevich-Mendelson, V. Grabovsky, S. W. Feigelson, G. Cinamon, Y. Gore, G. Goverse, S. J. Monkley, R. Margalit, D. Melamed, R. E. Mebius, et al. (2010)
Blood 116, 5907-5918
 |  Abstract »  |  Full Text »  |  PDF »

SHEP1 partners with CasL to promote marginal zone B-cell maturation.

C. D. Browne, M. M. Hoefer, S. K. Chintalapati, M. H. Cato, Y. Wallez, D. V. Ostertag, E. B. Pasquale, and R. C. Rickert (2010)
PNAS 107, 18944-18949
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell-Independent Immune Responses Do Not Require Cxc Ligand 13-Mediated B1 Cell Migration.

M. J. Colombo, G. Sun, and K. R. Alugupalli (2010)
Infect. Immun. 78, 3950-3956
 |  Abstract »  |  Full Text »  |  PDF »

Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.

C. L. Swanson, T. J. Wilson, P. Strauch, M. Colonna, R. Pelanda, and R. M. Torres (2010)
J. Exp. Med. 207, 1485-1500
 |  Abstract »  |  Full Text »  |  PDF »

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses.

J. P. Pereira, L. M. Kelly, and J. G. Cyster (2010)
Int. Immunol. 22, 413-419
 |  Abstract »  |  Full Text »  |  PDF »

Molecular regulators of leucocyte chemotaxis during inflammation.

C. H. Y. Wong, B. Heit, and P. Kubes (2010)
Cardiovasc Res 86, 183-191
 |  Abstract »  |  Full Text »  |  PDF »

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis.

M. Staron, Y. Yang, B. Liu, J. Li, Y. Shen, J. C. Zuniga-Pflucker, H. L. Aguila, I. Goldschneider, and Z. Li (2010)
Blood 115, 2380-2390
 |  Abstract »  |  Full Text »  |  PDF »

Progenitor Cell Origin Plays a Role in Fate Choices of Mature B Cells.

V. Fossati, R. Kumar, and H.-W. Snoeck (2010)
J. Immunol. 184, 1251-1260
 |  Abstract »  |  Full Text »  |  PDF »

Phosphoinositide 3-Kinase p110{delta} Regulates Natural Antibody Production, Marginal Zone and B-1 B Cell Function, and Autoantibody Responses.

C. A. Durand, K. Hartvigsen, L. Fogelstrand, S. Kim, S. Iritani, B. Vanhaesebroeck, J. L. Witztum, K. D. Puri, and M. R. Gold (2009)
J. Immunol. 183, 5673-5684
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Primary and Secondary Effects of CD19 Deficiency on Cells of the Marginal Zone.

Y. You, H. Zhao, Y. Wang, and R. H. Carter (2009)
J. Immunol. 182, 7343-7347
 |  Abstract »  |  Full Text »  |  PDF »

Wiskott-Aldrich Syndrome Protein Is Required for Homeostasis and Function of Invariant NKT Cells.

A. Astrakhan, H. D. Ochs, and D. J. Rawlings (2009)
J. Immunol. 182, 7370-7380
 |  Abstract »  |  Full Text »  |  PDF »

Role of Marginal Zone B Lymphocytes in Invariant NKT Cell Activation.

E. Bialecki, C. Paget, J. Fontaine, M. Capron, F. Trottein, and C. Faveeuw (2009)
J. Immunol. 182, 6105-6113
 |  Abstract »  |  Full Text »  |  PDF »

WASp stings mature lymphocytes.

E. Severinson (2008)
Blood 112, 3921-3922
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WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.

L. S. Westerberg, M. A. de la Fuente, F. Wermeling, H. D. Ochs, M. C. I. Karlsson, S. B. Snapper, and L. D. Notarangelo (2008)
Blood 112, 4139-4147
 |  Abstract »  |  Full Text »  |  PDF »

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.

A. Meyer-Bahlburg, S. Becker-Herman, S. Humblet-Baron, S. Khim, M. Weber, G. Bouma, A. J. Thrasher, F. D. Batista, and D. J. Rawlings (2008)
Blood 112, 4158-4169
 |  Abstract »  |  Full Text »  |  PDF »

Rap1b Regulates B Cell Development, Homing, and T Cell-Dependent Humoral Immunity.

H. Chu, A. Awasthi, G. C. White II, M. Chrzanowska-Wodnicka, and S. Malarkannan (2008)
J. Immunol. 181, 3373-3383
 |  Abstract »  |  Full Text »  |  PDF »

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.

B. Liu and Z. Li (2008)
Blood 112, 1223-1230
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of integrin activation through the B-cell receptor.

E. Arana, N. E. Harwood, and F. D. Batista (2008)
J. Cell Sci. 121, 2279-2286
 |  Abstract »  |  Full Text »  |  PDF »

Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.

Y. Moriyama, C. Sekine, A. Koyanagi, N. Koyama, H. Ogata, S. Chiba, S. Hirose, K. Okumura, and H. Yagita (2008)
Int. Immunol. 20, 763-773
 |  Abstract »  |  Full Text »  |  PDF »

DNA Microarray Gene Expression Profile of Marginal Zone versus Follicular B Cells and Idiotype Positive Marginal Zone B Cells before and after Immunization with Streptococcus pneumoniae.

N. W. Kin, D. M. Crawford, J. Liu, T. W. Behrens, and J. F. Kearney (2008)
J. Immunol. 180, 6663-6674
 |  Abstract »  |  Full Text »  |  PDF »

A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.

Y. Chen, M. Yu, A. Podd, R. Wen, M. Chrzanowska-Wodnicka, G. C. White, and D. Wang (2008)
Blood 111, 4627-4636
 |  Abstract »  |  Full Text »  |  PDF »

TLR Agonists Promote Marginal Zone B Cell Activation and Facilitate T-Dependent IgM Responses.

A. V. Rubtsov, C. L. Swanson, S. Troy, P. Strauch, R. Pelanda, and R. M. Torres (2008)
J. Immunol. 180, 3882-3888
 |  Abstract »  |  Full Text »  |  PDF »

Marginal-Zone B-Cells of Nonobese Diabetic Mice Expand With Diabetes Onset, Invade the Pancreatic Lymph Nodes, and Present Autoantigen to Diabetogenic T-Cells.

E. Marino, M. Batten, J. Groom, S. Walters, D. Liuwantara, F. Mackay, and S. T. Grey (2008)
Diabetes 57, 395-404
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Long-Lived Plasma Cells and Serological Memory Despite Mature and Memory B Cell Depletion during CD20 Immunotherapy in Mice.

D. J. DiLillo, Y. Hamaguchi, Y. Ueda, K. Yang, J. Uchida, K. M. Haas, G. Kelsoe, and T. F. Tedder (2008)
J. Immunol. 180, 361-371
 |  Abstract »  |  Full Text »  |  PDF »

Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen.

N. Czeloth, A. Schippers, N. Wagner, W. Muller, B. Kuster, G. Bernhardt, and R. Forster (2007)
J. Immunol. 179, 5855-5863
 |  Abstract »  |  Full Text »  |  PDF »

The role of ICAM-1 in endotoxin-induced acute renal failure.

X. Wu, R. Guo, Y. Wang, and P. N. Cunningham (2007)
Am J Physiol Renal Physiol 293, F1262-F1271
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive alternative NF-{kappa}B signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen.

F. Guo, D. Weih, E. Meier, and F. Weih (2007)
Blood 110, 2381-2389
 |  Abstract »  |  Full Text »  |  PDF »

Serum Response Factor Contributes Selectively to Lymphocyte Development.

A. Fleige, S. Alberti, L. Grobe, U. Frischmann, R. Geffers, W. Muller, A. Nordheim, and A. Schippers (2007)
J. Biol. Chem. 282, 24320-24328
 |  Abstract »  |  Full Text »  |  PDF »

The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations.

A. Cariappa, C. Boboila, S. T. Moran, H. Liu, H. N. Shi, and S. Pillai (2007)
J. Immunol. 179, 2270-2281
 |  Abstract »  |  Full Text »  |  PDF »

Effects of TNF-{alpha} on Leukocyte Adhesion Molecule Expressions in Cultured Human Lymphatic Endothelium.

Y. Sawa, Y. Sugimoto, T. Ueki, H. Ishikawa, A. Sato, T. Nagato, and S. Yoshida (2007)
Journal of Histochemistry & Cytochemistry 55, 721-733
 |  Abstract »  |  Full Text »  |  PDF »

Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection.

A. A. Belperron, C. M. Dailey, C. J. Booth, and L. K. Bockenstedt (2007)
Infect. Immun. 75, 3354-3360
 |  Abstract »  |  Full Text »  |  PDF »

Synergism between NF-{kappa}B1/p50 and Notch2 during the Development of Marginal Zone B Lymphocytes.

S. T. Moran, A. Cariappa, H. Liu, B. Muir, D. Sgroi, C. Boboila, and S. Pillai (2007)
J. Immunol. 179, 195-200
 |  Abstract »  |  Full Text »  |  PDF »

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency.

R. Castriconi, A. Dondero, C. Cantoni, M. Della Chiesa, C. Prato, M. Nanni, M. Fiorini, L. Notarangelo, S. Parolini, L. Moretta, et al. (2007)
Blood 109, 4873-4881
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Memory Antibody Levels: The Role of Persisting Antigen versus Plasma Cell Life Span.

D. Gatto, S. W. Martin, J. Bessa, E. Pellicioli, P. Saudan, H. J. Hinton, and M. F. Bachmann (2007)
J. Immunol. 178, 67-76
 |  Abstract »  |  Full Text »  |  PDF »

Lysophospholipids Control Integrin-dependent Adhesion in Splenic B Cells through Gi and G12/G13 Family G-proteins but Not through Gq/G11.

S. Rieken, S. Herroeder, A. Sassmann, B. Wallenwein, A. Moers, S. Offermanns, and N. Wettschureck (2006)
J. Biol. Chem. 281, 36985-36992
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of B1 cell migration by signals through Toll-like receptors.

S.-a. Ha, M. Tsuji, K. Suzuki, B. Meek, N. Yasuda, T. Kaisho, and S. Fagarasan (2006)
J. Exp. Med. 203, 2541-2550
 |  Abstract »  |  Full Text »  |  PDF »

Elimination of chronic viral infection by blocking CD27 signaling.

M. Matter, B. Odermatt, H. Yagita, J.-M. Nuoffer, and A. F. Ochsenbein (2006)
J. Exp. Med. 203, 2145-2155
 |  Abstract »  |  Full Text »  |  PDF »

G12/G13 family g proteins regulate marginal zone B cell maturation, migration, and polarization..

S. Rieken, A. Sassmann, S. Herroeder, B. Wallenwein, A. Moers, S. Offermanns, and N. Wettschureck (2006)
J. Immunol. 177, 2985-2993
 |  Abstract »  |  Full Text »  |  PDF »

Contrasting Roles for Domain 4 of VCAM-1 in the Regulation of Cell Adhesion and Soluble VCAM-1 Binding to Integrin {alpha}4beta1..

D. G. Woodside, R. M. Kram, J. S. Mitchell, T. Belsom, M. J. Billard, B. W. McIntyre, and P. Vanderslice (2006)
J. Immunol. 176, 5041-5049
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Induction of IL-13 Expression in NK Cells: Role of CD244 and SLAM-Associated Protein..

N. Gao, P. Schwartzberg, J. A. Wilder, B. R. Blazar, and D. Yuan (2006)
J. Immunol. 176, 2758-2764
 |  Abstract »  |  Full Text »  |  PDF »

Multiple eicosanoid-activated nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands.

X. Liu, P. Zhu, and B. D. Freedman (2006)
Am J Physiol Cell Physiol 290, C873-C882
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr-Virus-Encoded LMP2A Induces Primary Epithelial Cell Migration and Invasion: Possible Role in Nasopharyngeal Carcinoma Metastasis.

D. M. Pegtel, A. Subramanian, T.-S. Sheen, C.-H. Tsai, T. R. Golub, and D. A. Thorley-Lawson (2005)
J. Virol. 79, 15430-15442
 |  Abstract »  |  Full Text »  |  PDF »

CXCR5-Dependent Seeding of Follicular Niches by B and Th Cells Augments Antiviral B Cell Responses.

T. Junt, K. Fink, R. Forster, B. Senn, M. Lipp, M. Muramatsu, R. M. Zinkernagel, B. Ludewig, and H. Hengartner (2005)
J. Immunol. 175, 7109-7116
 |  Abstract »  |  Full Text »  |  PDF »

Staphylococcal Protein A Deletes B-1a and Marginal Zone B Lymphocytes Expressing Human Immunoglobulins: An Immune Evasion Mechanism.

M. Viau, N. S. Longo, P. E. Lipsky, and M. Zouali (2005)
J. Immunol. 175, 7719-7727
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of marginal zone B cell precursors.

B. Srivastava, W. J. Quinn III, K. Hazard, J. Erikson, and D. Allman (2005)
J. Exp. Med. 202, 1225-1234
 |  Abstract »  |  Full Text »  |  PDF »

Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance.

S. Seo, T. Asai, T. Saito, T. Suzuki, Y. Morishita, T. Nakamoto, M. Ichikawa, G. Yamamoto, M. Kawazu, T. Yamagata, et al. (2005)
J. Immunol. 175, 3492-3501
 |  Abstract »  |  Full Text »  |  PDF »

The CD9 Tetraspanin Is Not Required for the Development of Peripheral B Cells or for Humoral Immunity.

A. Cariappa, T. Shoham, H. Liu, S. Levy, C. Boucheix, and S. Pillai (2005)
J. Immunol. 175, 2925-2930
 |  Abstract »  |  Full Text »  |  PDF »

Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement.

K. A. Vora, E. Nichols, G. Porter, Y. Cui, C. A. Keohane, R. Hajdu, J. Hale, W. Neway, D. Zaller, and S. Mandala (2005)
J. Leukoc. Biol. 78, 471-480
 |  Abstract »  |  Full Text »  |  PDF »

Fc{gamma}RIIIB stimulation promotes {beta}1 integrin activation in human neutrophils.

A. Ortiz-Stern and C. Rosales (2005)
J. Leukoc. Biol. 77, 787-799
 |  Abstract »  |  Full Text »  |  PDF »

Infection-Induced Marginal Zone B Cell Production of Borrelia hermsii-Specific Antibody Is Impaired in the Absence of CD1d.

A. A. Belperron, C. M. Dailey, and L. K. Bockenstedt (2005)
J. Immunol. 174, 5681-5686
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Hyperresponsiveness and Expansion of Mature Follicular B Cells but Not of Marginal Zone B Cells in NFATc2/c3 Double-Deficient Mice.

D. N. Samanta, A. Palmetshofer, D. Marinkovic, T. Wirth, E. Serfling, and L. Nitschke (2005)
J. Immunol. 174, 4797-4802
 |  Abstract »  |  Full Text »  |  PDF »

The Enlarged Population of Marginal Zone/CD1dhigh B Lymphocytes in Nonobese Diabetic Mice Maps to Diabetes Susceptibility Region Idd11.

J. Rolf, V. Motta, N. Duarte, M. Lundholm, E. Berntman, M.-L. Bergman, L. Sorokin, S. L. Cardell, and D. Holmberg (2005)
J. Immunol. 174, 4821-4827
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Marginal Zone B Cell Development in the Mouse with Limited B Cell Diversity: Role of the Antigen Receptor Signals in the Recruitment of B Cells to the Marginal Zone.

N. Kanayama, M. Cascalho, and H. Ohmori (2005)
J. Immunol. 174, 1438-1445
 |  Abstract »  |  Full Text »  |  PDF »

Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response.

L. Westerberg, M. Larsson, S. J. Hardy, C. Fernandez, A. J. Thrasher, and E. Severinson (2005)
Blood 105, 1144-1152
 |  Abstract »  |  Full Text »  |  PDF »

Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy.

Q. Gong, Q. Ou, S. Ye, W. P. Lee, J. Cornelius, L. Diehl, W. Y. Lin, Z. Hu, Y. Lu, Y. Chen, et al. (2005)
J. Immunol. 174, 817-826
 |  Abstract »  |  Full Text »  |  PDF »

The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P3 Regulates MAdCAM-1+ Endothelial Cells in Splenic Marginal Sinus Organization.

I. Girkontaite, V. Sakk, M. Wagner, T. Borggrefe, K. Tedford, J. Chun, and K.-D. Fischer (2004)
J. Exp. Med. 200, 1491-1501
 |  Abstract »  |  Full Text »  |  PDF »

B cell signalling as therapeutic target.

R H Carter (2004)
Ann Rheum Dis 63, ii65-ii66
 |  Full Text »  |  PDF »

Rapid Response of Marginal Zone B Cells to Viral Particles.

D. Gatto, C. Ruedl, B. Odermatt, and M. F. Bachmann (2004)
J. Immunol. 173, 4308-4316
 |  Abstract »  |  Full Text »  |  PDF »

LFA-1 on CD4+ T Cells Is Required for Optimal Antigen-Dependent Activation In Vivo.

S. Kandula and C. Abraham (2004)
J. Immunol. 173, 4443-4451
 |  Abstract »  |  Full Text »  |  PDF »

Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells.

A. R. Ferguson, M. E. Youd, and R. B. Corley (2004)
Int. Immunol. 16, 1411-1422
 |  Abstract »  |  Full Text »  |  PDF »

Analyses of the In Vivo Trafficking of Stoichiometric Doses of an Anti-Complement Receptor 1/2 Monoclonal Antibody Infused Intravenously in Mice.

E. C. Whipple, R. S. Shanahan, A. H. Ditto, R. P. Taylor, and M. A. Lindorfer (2004)
J. Immunol. 173, 2297-2306
 |  Abstract »  |  Full Text »  |  PDF »

Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.

C. S. Goodyear and G. J. Silverman (2004)
PNAS 101, 11392-11397
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-Specific Lymphocyte Sequestration in Lymphoid Organs: Lack of Essential Roles for {alpha}L and {alpha}4 Integrin-Dependent Adhesion or G{alpha}i Protein-Coupled Receptor Signaling.

C. N. Arnold, E. C. Butcher, and D. J. Campbell (2004)
J. Immunol. 173, 866-873
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B Cell Positive Selection: Road Map to the Primary Repertoire?.

M. P. Cancro and J. F. Kearney (2004)
J. Immunol. 173, 15-19
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Separation of the New Zealand Black Genetic Contribution to Lupus from New Zealand Black Determined Expansions of Marginal Zone B and B1a Cells.

S. Atencio, H. Amano, S. Izui, and B. L. Kotzin (2004)
J. Immunol. 172, 4159-4166
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Mechanisms Governing B Cell Developmental Defects in Invariant Chain-Deficient Mice.

K. Benlagha, S.-H. Park, R. Guinamard, C. Forestier, L. Karlsson, C.-H. Chang, and A. Bendelac (2004)
J. Immunol. 172, 2076-2083
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The Selection of Marginal Zone B Cells Differs from That of B-1a Cells.

K. Kretschmer, A. Jungebloud, J. Stopkowicz, T. Kleinke, R. Hoffmann, and S. Weiss (2003)
J. Immunol. 171, 6495-6501
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Macrophages Control the Retention and Trafficking of B Lymphocytes in the Splenic Marginal Zone.

M. C.I. Karlsson, R. Guinamard, S. Bolland, M. Sankala, R. M. Steinman, and J. V. Ravetch (2003)
J. Exp. Med. 198, 333-340
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Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response.

K. A. Pape, V. Kouskoff, D. Nemazee, H. L. Tang, J. G. Cyster, L. E. Tze, K. L. Hippen, T. W. Behrens, and M. K. Jenkins (2003)
J. Exp. Med. 197, 1677-1687
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B Cell-specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice.

C. Brunner, D. Marinkovic, J. Klein, T. Samardzic, L. Nitschke, and T. Wirth (2003)
J. Exp. Med. 197, 1205-1211
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The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells.

H. Amano, E. Amano, T. Moll, D. Marinkovic, N. Ibnou-Zekri, E. Martinez-Soria, I. Semac, T. Wirth, L. Nitschke, and S. Izui (2003)
J. Immunol. 170, 2293-2301
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Integrin-dependence of Lymphocyte Entry into the Splenic White Pulp.

C. G. Lo, T. T. Lu, and J. G. Cyster (2003)
J. Exp. Med. 197, 353-361
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Intrinsic Differences in the Proliferation of Naive and Memory Human B Cells as a Mechanism for Enhanced Secondary Immune Responses.

S. G. Tangye, D. T. Avery, E. K. Deenick, and P. D. Hodgkin (2003)
J. Immunol. 170, 686-694
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BOB.1/OBF.1 Deficiency Affects Marginal-Zone B-Cell Compartment.

T. Samardzic, D. Marinkovic, P. J. Nielsen, L. Nitschke, and T. Wirth (2002)
Mol. Cell. Biol. 22, 8320-8331
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