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Science 297 (5581): 557-558

Copyright © 2002 by the American Association for the Advancement of Science

Checking That Replication Breakdown Is Not Terminal

Antony M. Carr

Two new studies help to clarify the relationship between checkpoint proteins, recombination, and replication fork integrity.

Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. E-mail: a.m.carr{at}

Functional Analysis of DNA Replication Fork Reversal Catalyzed by Mycobacterium tuberculosis RuvAB Proteins.
J. S. Khanduja and K. Muniyappa (2012)
J. Biol. Chem. 287, 1345-1360
   Abstract »    Full Text »    PDF »
Replication Stress Leads to Genome Instabilities in Arabidopsis DNA Polymerase {delta} Mutants.
D. Schuermann, O. Fritsch, J. M. Lucht, and B. Hohn (2009)
PLANT CELL 21, 2700-2714
   Abstract »    Full Text »    PDF »
Transcription of a Donor Enhances Its Use during Double-Strand Break-Induced Gene Conversion in Human Cells.
E. Schildkraut, C. A. Miller, and J. A. Nickoloff (2006)
Mol. Cell. Biol. 26, 3098-3105
   Abstract »    Full Text »    PDF »
RuvAB is essential for replication forks reversal in certain replication mutants.
Z. Baharoglu, M. Petranovic, M.-J. Flores, and B. Michel (2006)
EMBO J. 25, 596-604
   Abstract »    Full Text »    PDF »
Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.
M. Kai, M. N. Boddy, P. Russell, and T. S.-F. Wang (2005)
Genes & Dev. 19, 919-932
   Abstract »    Full Text »    PDF »
SMC1 involvement in fragile site expression.
A. Musio, C. Montagna, T. Mariani, M. Tilenni, M. L. Focarelli, L. Brait, E. Indino, P. A. Benedetti, L. Chessa, A. Albertini, et al. (2005)
Hum. Mol. Genet. 14, 525-533
   Abstract »    Full Text »    PDF »
The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants.
M. J. Flores, V. Bidnenko, and B. Michel (2004)
EMBO Rep. 5, 983-988
   Abstract »    Full Text »    PDF »
From The Cover: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
D. Cortez, G. Glick, and S. J. Elledge (2004)
PNAS 101, 10078-10083
   Abstract »    Full Text »    PDF »
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.
K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
Mol. Cell. Biol. 24, 5050-5059
   Abstract »    Full Text »    PDF »
Cells defective for replication restart undergo replication fork reversal.
G. Grompone, D. Ehrlich, and B. Michel (2004)
EMBO Rep. 5, 607-612
   Abstract »    Full Text »    PDF »
Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses.
R. W. Sobol, M. Kartalou, K. H. Almeida, D. F. Joyce, B. P. Engelward, J. K. Horton, R. Prasad, L. D. Samson, and S. H. Wilson (2003)
J. Biol. Chem. 278, 39951-39959
   Abstract »    Full Text »    PDF »
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
E. J. Brown and D. Baltimore (2003)
Genes & Dev. 17, 615-628
   Abstract »    Full Text »    PDF »
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects.
G. Zachos, M. D. Rainey, and D. A. F. Gillespie (2003)
EMBO J. 22, 713-723
   Abstract »    Full Text »    PDF »

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