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Science 297 (5581): 557-558

Copyright © 2002 by the American Association for the Advancement of Science

Checking That Replication Breakdown Is Not Terminal

Antony M. Carr

Two new studies help to clarify the relationship between checkpoint proteins, recombination, and replication fork integrity.

Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. E-mail: a.m.carr{at}sussex.ac.uk



THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Replication Stress Leads to Genome Instabilities in Arabidopsis DNA Polymerase {delta} Mutants.
D. Schuermann, O. Fritsch, J. M. Lucht, and B. Hohn (2009)
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Transcription of a Donor Enhances Its Use during Double-Strand Break-Induced Gene Conversion in Human Cells.
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RuvAB is essential for replication forks reversal in certain replication mutants.
Z. Baharoglu, M. Petranovic, M.-J. Flores, and B. Michel (2006)
EMBO J. 25, 596-604
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Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.
M. Kai, M. N. Boddy, P. Russell, and T. S.-F. Wang (2005)
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SMC1 involvement in fragile site expression.
A. Musio, C. Montagna, T. Mariani, M. Tilenni, M. L. Focarelli, L. Brait, E. Indino, P. A. Benedetti, L. Chessa, A. Albertini, et al. (2005)
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The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants.
M. J. Flores, V. Bidnenko, and B. Michel (2004)
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From The Cover: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.
D. Cortez, G. Glick, and S. J. Elledge (2004)
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Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.
K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
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Cells defective for replication restart undergo replication fork reversal.
G. Grompone, D. Ehrlich, and B. Michel (2004)
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Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses.
R. W. Sobol, M. Kartalou, K. H. Almeida, D. F. Joyce, B. P. Engelward, J. K. Horton, R. Prasad, L. D. Samson, and S. H. Wilson (2003)
J. Biol. Chem. 278, 39951-39959
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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance.
E. J. Brown and D. Baltimore (2003)
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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects.
G. Zachos, M. D. Rainey, and D. A. F. Gillespie (2003)
EMBO J. 22, 713-723
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