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Science 297 (5582): 840-843

Copyright © 2002 by the American Association for the Advancement of Science

White Collar-1, a DNA Binding Transcription Factor and a Light Sensor

Qiyang He,1* Ping Cheng,1* Yuhong Yang,1 Lixing Wang,1 Kevin H. Gardner,2 Yi Liu1dagger

Blue light regulates many physiological processes in fungi, but their photoreceptors are not known. In Neurospora crassa, all light responses depend on the Per-Arnt-Sim (PAS) domain-containing transcription factor white collar-1 (wc-1). By removing the WC-1 light, oxygen, or voltage domain, a specialized PAS domain that binds flavin mononucleotide in plant phototropins, we show that light responses are abolished, including light entrainment of the circadian clock. However, the WC-1-mediated dark activation of frq remains normal in this mutant, and the circadian clock can be entrained by temperature. Furthermore, we demonstrate that the purified Neurospora WC-1-WC-2 protein complex is associated with stoichiometric amounts of the chromophore flavin-adenine dinucleotide. Together, these observations suggest that WC-1 is the blue-light photoreceptor for the circadian clock and other light responses in Neurospora.

1 Department of Physiology,
2 Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: Yi.Liu{at}UTsouthwestern.edu



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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Full Text »    PDF »
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   Abstract »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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A. C. Froehlich, B. Noh, R. D. Vierstra, J. Loros, and J. C. Dunlap (2005)
Eukaryot. Cell 4, 2140-2152
   Abstract »    Full Text »    PDF »
Molecular mechanism of light responses in Neurospora: from light-induced transcription to photoadaptation.
Q. He and Y. Liu (2005)
Genes & Dev. 19, 2888-2899
   Abstract »    Full Text »    PDF »
Independent Roles for EARLY FLOWERING 3 and ZEITLUPE in the Control of Circadian Timing, Hypocotyl Length, and Flowering Time.
W.-Y. Kim, K. A. Hicks, and D. E. Somers (2005)
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   Abstract »    Full Text »    PDF »
The dst1 Gene Involved in Mushroom Photomorphogenesis of Coprinus cinereus Encodes a Putative Photoreceptor for Blue Light.
K. Terashima, K. Yuki, H. Muraguchi, M. Akiyama, and T. Kamada (2005)
Genetics 171, 101-108
   Abstract »    Full Text »    PDF »
The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex.
Q. He, P. Cheng, Q. He, and Y. Liu (2005)
Genes & Dev. 19, 1518-1531
   Abstract »    Full Text »    PDF »
Light-independent Phosphorylation of WHITE COLLAR-1 Regulates Its Function in the Neurospora Circadian Negative Feedback Loop.
Q. He, H. Shu, P. Cheng, S. Chen, L. Wang, and Y. Liu (2005)
J. Biol. Chem. 280, 17526-17532
   Abstract »    Full Text »    PDF »
Regulation of the Neurospora circadian clock by an RNA helicase.
P. Cheng, Q. He, Q. He, L. Wang, and Y. Liu (2005)
Genes & Dev. 19, 234-241
   Abstract »    Full Text »    PDF »
BLR-1 and BLR-2, key regulatory elements of photoconidiation and mycelial growth in Trichoderma atroviride.
S. Casas-Flores, M. Rios-Momberg, M. Bibbins, P. Ponce-Noyola, and A. Herrera-Estrella (2004)
Microbiology 150, 3561-3569
   Abstract »    Full Text »    PDF »
The Neurospora Circadian System.
J. C. Dunlap and J. J. Loros (2004)
J Biol Rhythms 19, 414-424
   Abstract »    PDF »
The Arabidopsis thaliana Clock.
P. A. Salome and C. R. McClung (2004)
J Biol Rhythms 19, 425-435
   Abstract »    PDF »
Clock Gene Evolution and Functional Divergence.
E. Tauber, K. S. Last, P. J.W. Olive, and C. P. Kyriacou (2004)
J Biol Rhythms 19, 445-458
   Abstract »    PDF »
Synergism between blue light and root exudate compounds and evidence for a second messenger in the hyphal branching response of Gigaspora gigantea.
G. Nagahashi and D. D. Douds Jr. (2004)
Mycologia 96, 948-954
   Abstract »    Full Text »    PDF »
A Genetic Selection for Circadian Output Pathway Mutations in Neurospora crassa.
M. W. Vitalini, L. W. Morgan, I. J. March, and D. Bell-Pedersen (2004)
Genetics 167, 119-129
   Abstract »    Full Text »    PDF »
COS1: An Arabidopsis coronatine insensitive1 Suppressor Essential for Regulation of Jasmonate-Mediated Plant Defense and Senescence.
S. Xiao, L. Dai, F. Liu, Z. Wang, W. Peng, and D. Xie (2004)
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   Abstract »    Full Text »    PDF »
Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism.
K. A. Borkovich, L. A. Alex, O. Yarden, M. Freitag, G. E. Turner, N. D. Read, S. Seiler, D. Bell-Pedersen, J. Paietta, N. Plesofsky, et al. (2004)
Microbiol. Mol. Biol. Rev. 68, 1-108
   Abstract »    Full Text »    PDF »
The F-Box Protein ZEITLUPE Confers Dosage-Dependent Control on the Circadian Clock, Photomorphogenesis, and Flowering Time.
D. E. Somers, W.-Y. Kim, and R. Geng (2004)
PLANT CELL 16, 769-782
   Abstract »    Full Text »    PDF »
Reactive Oxygen Species Affect Photomorphogenesis in Neurospora crassa.
Y. Yoshida and K. Hasunuma (2004)
J. Biol. Chem. 279, 6986-6993
   Abstract »    Full Text »    PDF »
Light-regulated asexual reproduction in Paecilomyces fumosoroseus.
R. I. Sanchez-Murillo, M. de la Torre-Martinez, J. Aguirre-Linares, and A. Herrera-Estrella (2004)
Microbiology 150, 311-319
   Abstract »    Full Text »    PDF »
Distinct roles for PP1 and PP2A in the Neurospora circadian clock.
Y. Yang, Q. He, P. Cheng, P. Wrage, O. Yarden, and Y. Liu (2004)
Genes & Dev. 18, 255-260
   Abstract »    Full Text »    PDF »
Multiple oscillators regulate circadian gene expression in Neurospora.
A. Correa, Z. A. Lewis, A. V. Greene, I. J. March, R. H. Gomer, and D. Bell-Pedersen (2003)
PNAS 100, 13597-13602
   Abstract »    Full Text »    PDF »
VIVID is a flavoprotein and serves as a fungal blue light photoreceptor for photoadaptation.
C. Schwerdtfeger and H. Linden (2003)
EMBO J. 22, 4846-4855
   Abstract »    Full Text »    PDF »
Phosphorylation of FREQUENCY Protein by Casein Kinase II Is Necessary for the Function of the Neurospora Circadian Clock.
Y. Yang, P. Cheng, Q. He, L. Wang, and Y. Liu (2003)
Mol. Cell. Biol. 23, 6221-6228
   Abstract »    Full Text »    PDF »
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation.
Q. He, P. Cheng, Y. Yang, Q. He, H. Yu, and Y. Liu (2003)
EMBO J. 22, 4421-4430
   Abstract »    Full Text »    PDF »
The frequency Gene Is Required for Temperature-Dependent Regulation of Many Clock-Controlled Genes in Neurospora crassa.
M. Nowrousian, G. E. Duffield, J. J. Loros, and J. C. Dunlap (2003)
Genetics 164, 923-933
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Entrainment in the Neurospora Circadian Clock.
Y. Liu (2003)
J Biol Rhythms 18, 195-205
   Abstract »    PDF »
Functional conservation of light, oxygen, or voltage domains in light sensing.
P. Cheng, Q. He, Y. Yang, L. Wang, and Y. Liu (2003)
PNAS 100, 5938-5943
   Abstract »    Full Text »    PDF »
A Circadian Oscillator in Aspergillus spp. Regulates Daily Development and Gene Expression.
A. V. Greene, N. Keller, H. Haas, and D. Bell-Pedersen (2003)
Eukaryot. Cell 2, 231-237
   Abstract »    Full Text »    PDF »
Crystal structure of a photoactive yellow protein from a sensor histidine kinase: Conformational variability and signal transduction.
S. Rajagopal and K. Moffat (2003)
PNAS 100, 1649-1654
   Abstract »    Full Text »    PDF »
WHITE COLLAR-1, a Multifunctional Neurospora Protein Involved in the Circadian Feedback Loops, Light Sensing, and Transcription Repression of wc-2.
P. Cheng, Y. Yang, L. Wang, Q. He, and Y. Liu (2003)
J. Biol. Chem. 278, 3801-3808
   Abstract »    Full Text »    PDF »
The Arabidopsis SRR1 gene mediates phyB signaling and is required for normal circadian clock function.
D. Staiger, L. Allenbach, N. Salathia, V. Fiechter, S. J. Davis, A. J. Millar, J. Chory, and C. Fankhauser (2003)
Genes & Dev. 17, 256-268
   Abstract »    Full Text »    PDF »
Roles for WHITE COLLAR-1 in Circadian and General Photoperception in Neurospora crassa.
K. Lee, J. C. Dunlap, and J. J. Loros (2003)
Genetics 163, 103-114
   Abstract »    Full Text »    PDF »
Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting.
S. Panda, T. K. Sato, A. M. Castrucci, M. D. Rollag, W. J. DeGrip, J. B. Hogenesch, I. Provencio, and S. A. Kay (2002)
Science 298, 2213-2216
   Abstract »    Full Text »    PDF »
Origins of Circadian Rhythmicity.
E. Rosato and C. P. Kyriacou (2002)
J Biol Rhythms 17, 506-511
   PDF »
CIRCADIAN RHYTHMS: Enhanced: A White Collar Protein Senses Blue Light.
H. Linden (2002)
Science 297, 777-778
   Full Text »    PDF »
White Collar-1, a Circadian Blue Light Photoreceptor, Binding to the frequency Promoter.
A. C. Froehlich, Y. Liu, J. J. Loros, and J. C. Dunlap (2002)
Science 297, 815-819
   Abstract »    Full Text »    PDF »

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