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Science 297 (5582): 854-857

Copyright © 2002 by the American Association for the Advancement of Science

Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina

Walter Muranyi,1* Jürgen Haas,1 Markus Wagner,1 Georg Krohne,2 Ulrich H. Koszinowski1dagger

The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a beta -herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture.

1 Genzentrum and Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universität München, 80336 München, Germany.
2 Division of Electron Microscopy, Biocenter of the University of Würzburg, 97074 Würzburg, Germany.
*   Present address: Abteilung Virologie, Hygiene-Institut, Ruprecht-Karls-Universität Heidelberg, 69120 Heidelberg, Germany.

dagger    To whom correspondence should be addressed. E-mail: koszinowski{at}m3401.mpk.med.uni-muenchen.de



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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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V Cenni, P Sabatelli, E Mattioli, S Marmiroli, C Capanni, A Ognibene, S Squarzoni, N M Maraldi, G Bonne, M Columbaro, et al. (2005)
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   Abstract »    Full Text »    PDF »
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B. Rupp, Z. Ruzsics, T. Sacher, and U. H. Koszinowski (2005)
J. Virol. 79, 486-494
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Virol. 78, 1314-1323
   Abstract »    Full Text »    PDF »
Effects of Charged Cluster Mutations on the Function of Herpes Simplex Virus Type 1 UL34 Protein.
S. L. Bjerke, J. M. Cowan, J. K. Kerr, A. E. Reynolds, J. D. Baines, and R. J. Roller (2003)
J. Virol. 77, 7601-7610
   Abstract »    Full Text »    PDF »
The Human Cytomegalovirus UL97 Protein Kinase, an Antiviral Drug Target, Is Required at the Stage of Nuclear Egress.
P. M. Krosky, M.-C. Baek, and D. M. Coen (2003)
J. Virol. 77, 905-914
   Abstract »    Full Text »    PDF »
VIROLOGY: CMV Makes a Timely Exit.
V. Sanchez and D. H. Spector (2002)
Science 297, 778-779
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