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SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly
Thomas Biederer,1*Yildirim Sara,1Marina Mozhayeva,1Deniz Atasoy,1Xinran Liu,12Ege T. Kavalali,13Thomas C. Südhof124*
Synapses, the junctions between nerve cells through
which they communicate, are formed by the coordinated assembly and
tightattachment of pre- and postsynaptic specializations. We now showthat SynCAM is a brain-specific, immunoglobulin
domain-containingprotein that binds to intracellular PDZ-domain
proteins and functionsas a homophilic cell adhesion molecule at the
synapse. Expressionof the isolated cytoplasmic tail of SynCAM in
neurons inhibitedsynapse assembly. Conversely, expression of
full-length SynCAMin nonneuronal cells induced synapse formation by
cocultured hippocampalneurons with normal release properties.
Glutamatergic synaptictransmission was reconstituted in these
nonneuronal cells by coexpressingglutamate receptors with SynCAM,
which suggests that a singletype of adhesion molecule and glutamate
receptor are sufficientfor a functional postsynaptic response.
1 Center for Basic Neuroscience, Departments of
2 Molecular Genetics, and
3 Physiology, and
4 Howard Hughes
Medical Institute, University of Texas Southwestern Medical Center,
Dallas, TX 75390, USA.
*
To whom correspondence should be addressed. E-mail:
Thomas.Sudhof{at}UTSouthwestern.edu (T.C.S.);
Thomas.Biederer{at}UTSouthwestern.edu(T.B.)
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J. Neurosci.
25, 5943-5955
|Abstract »|Full Text »|PDF »
Nectin-like Protein 2 Defines a Subset of T-cell Zone Dendritic Cells and Is a Ligand for Class-I-restricted T-cell-associated Molecule.
L. Galibert, G. S. Diemer, Z. Liu, R. S. Johnson, J. L. Smith, T. Walzer, M. R. Comeau, C. T. Rauch, M. F. Wolfson, R. A. Sorensen, et al. (2005)
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|Abstract »|Full Text »|PDF »
Dissection of Synapse Induction by Neuroligins: EFFECT OF A NEUROLIGIN MUTATION ASSOCIATED WITH AUTISM.
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280, 22365-22374
|Abstract »|Full Text »|PDF »
Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter.
TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses.
B. W. Luikart, S. Nef, T. Virmani, M. E. Lush, Y. Liu, E. T. Kavalali, and L. F. Parada (2005)
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25, 3774-3786
|Abstract »|Full Text »|PDF »
Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation.
