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Science 297 (5589): 2060-2063

Copyright © 2002 by the American Association for the Advancement of Science

A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory

Christine Bourgeois, Benedita Rocha, Corinne Tanchot*

The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation.

INSERM U345, Institut Necker, 156 Rue de Vaugirard, F-75730 Paris Cedex 15, France.
*   To whom correspondence should be addressed. E-mail: tanchot{at}necker.fr

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Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells.
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J. Immunol. 173, 883-891
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Fully Functional Memory CD8 T Cells in the Absence of CD4 T Cells.
A. L. Marzo, V. Vezys, K. D. Klonowski, S.-J. Lee, G. Muralimohan, M. Moore, D. F. Tough, and L. Lefrancois (2004)
J. Immunol. 173, 969-975
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