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Science 297 (5589): 2060-2063

Copyright © 2002 by the American Association for the Advancement of Science

A Role for CD40 Expression on CD8+ T Cells in the Generation of CD8+ T Cell Memory

Christine Bourgeois, Benedita Rocha, Corinne Tanchot*

The delivery of CD4 help to CD8+ T cell responses requires interactions between CD40 and CD40 ligand and is thought to occur through antigen-presenting cell (APC) activation. Here we show that generation of memory CD8+ T cells displaying an enhanced capacity for cell division and cytokine secretion required CD4 help but not CD40 expression by the APCs. Activated CD4+ and CD8+ T cells expressed CD40; and in the absence of this protein, CD8+ T cells were unable to differentiate into memory cells or receive CD4 help. These results suggest that, like B cells, CD8+ T cells receive CD4 help directly through CD40 and that this interaction is fundamental for CD8+ T cell memory generation.

INSERM U345, Institut Necker, 156 Rue de Vaugirard, F-75730 Paris Cedex 15, France.
*   To whom correspondence should be addressed. E-mail: tanchot{at}necker.fr



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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
OX40 Ligation of CD4+ T Cells Enhances Virus-Specific CD8+ T Cell Memory Responses Independently of IL-2 and CD4+ T Regulatory Cell Inhibition.
Q. Yu, F. Y. Yue, X. X. Gu, H. Schwartz, C. M. Kovacs, and M. A. Ostrowski (2006)
J. Immunol. 176, 2486-2495
   Abstract »    Full Text »    PDF »
Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS.
C. Ling, M. Sandor, M. Suresh, and Z. Fabry (2006)
J. Neurosci. 26, 731-741
   Abstract »    Full Text »    PDF »
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines.
G. Zhou, C. G. Drake, and H. I. Levitsky (2006)
Blood 107, 628-636
   Abstract »    Full Text »    PDF »
Antibodies and CD8+ T Cells Are Complementary and Essential for Natural Resistance to a Highly Lethal Cytopathic Virus.
M. Fang and L. J. Sigal (2005)
J. Immunol. 175, 6829-6836
   Abstract »    Full Text »    PDF »
Expansion and Contraction of HIV-Specific CD4 T Cells with Short Bursts of Viremia, but Physical Loss of the Majority of These Cells with Sustained Viral Replication.
N. Seth, D. Kaufmann, T. Lahey, E. S. Rosenberg, and K. W. Wucherpfennig (2005)
J. Immunol. 175, 6948-6958
   Abstract »    Full Text »    PDF »
Coexpression of CD40 and CD40 Ligand in Epstein-Barr Virus-Infected T and NK Cells and Their Role in Cell Survival.
K.-I. Imadome, N. Shimizu, A. Arai, O. Miura, K. Watanabe, H. Nakamura, S. Nonoyama, K. Yamamoto, and S. Fujiwara (2005)
The Journal of Infectious Disease 192, 1340-1348
   Abstract »    Full Text »    PDF »
Transfection of Trypanosoma cruzi with Host CD40 Ligand Results in Improved Control of Parasite Infection.
M. Chamekh, V. Vercruysse, M. Habib, M. Lorent, M. Goldman, A. Allaoui, and B. Vray (2005)
Infect. Immun. 73, 6552-6561
   Abstract »    Full Text »    PDF »
IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization.
M.-H. Lacombe, M.-P. Hardy, J. Rooney, and N. Labrecque (2005)
J. Immunol. 175, 4400-4407
   Abstract »    Full Text »    PDF »
A Novel Role of CD30/CD30 Ligand Signaling in the Generation of Long-Lived Memory CD8+ T Cells.
H. Nishimura, T. Yajima, H. Muta, E. R. Podack, K. Tani, and Y. Yoshikai (2005)
J. Immunol. 175, 4627-4634
   Abstract »    Full Text »    PDF »
Recall Proliferation Potential of Memory CD8+ T Cells and Antiviral Protection.
M. F. Bachmann, P. Wolint, K. Schwarz, and A. Oxenius (2005)
J. Immunol. 175, 4677-4685
   Abstract »    Full Text »    PDF »
2B4/CD48-Mediated Regulation of Lymphocyte Activation and Function.
E. Assarsson, T. Kambayashi, C. M. Persson, B. J. Chambers, and H.-G. Ljunggren (2005)
J. Immunol. 175, 2045-2049
   Abstract »    Full Text »    PDF »
A New Dynamic Model of CD8+ T Effector Cell Responses via CD4+ T Helper-Antigen-Presenting Cells.
J. Xiang, H. Huang, and Y. Liu (2005)
J. Immunol. 174, 7497-7505
   Abstract »    Full Text »    PDF »
CD4 T Cell-Dependent Conditioning of Dendritic Cells to Produce IL-12 Results in CD8-Mediated Graft Rejection and Avoidance of Tolerance.
A. A. Filatenkov, E. L. Jacovetty, U. B. Fischer, J. M. Curtsinger, M. F. Mescher, and E. Ingulli (2005)
J. Immunol. 174, 6909-6917
   Abstract »    Full Text »    PDF »

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